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| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Assessment and treatment of endothelial dysfunction in humans显示文摘 | Anderson TJ | | 0，，： | 2 |
| 3 | Assessment and treatment of endothelium dysfunction in humans 显示文摘 | Anderson TJ | 1999 | J Am Coil Cardiol1999，34，3： | 1 |
| 4 | Endothelialfunction testing as a biomarker of vascular disease显示文摘 | Verma S Buchanan MR Anderson TJ | 2003 | Circulation2003，108，17： | 1 |
| 5 | Granulomatouslobular mastitis显示文摘 | Going JJ Anderson TJ Wilkinson S | 1987 | J Clin Pathol1987，40，5： | 1 |
| 6 | Risk prediction in cardiovascular disease: the prognostic significance of endothelial dysfunction显示文摘 | Martin BJ Anderson TJ | 2009 | Can J Cardiol2009，25，： | 1 |
| 7 | The endothelium in health and disease-- target for therapeutic intervention显示文摘 | Triggle CR Hollenberg M Anderson TJ | 2003 | Smooth Muscle Res2003，39，6： | 1 |
| 8 | Nitric oxide,atherosclerosis and the clinical relevance of endothelial dysfunction 显示文摘 | Anderson TJ | 2003 | Heart Fail Rev2003，8，1： | 1 |
| 9 | Close relation of endothelial function in the human coronary and peripheral circualations显示文摘 | Anderson TJ Uehata A Gerhard MD | 1995 | J Am Coll Cardiol1995，26，： | 1 |
| 10 | Targeting ICAM - 1/LFA - 1 interaction for controlling autoimmune diseases: designing peptide and small mol- ecule inhibitors 显示文摘 | Anderson ME Siahaan TJ | 2003 | Peptides2003，24，3： | 1 |
| 11 | Reversible posterior leukoencephalopathy syndrome:a misnomer reviewed显示文摘 | Stott VL Hurrell MA Anderson TJ | | 0，，2： | 1 |
| 12 | Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium parciparum 显示文摘 | Anderson TJ Haubold B Williams JT | 2000 | Mol Biol Evol2000，17，10： | 1 |
| 13 | Twenty year follow up of a randomized trial comparing total masteetomy, lumpeetomy,and lumpeetomy plus irradiaton for the treatment of invasive breast cancer显示文摘 | Fisifer B Anderson S Bryan TJ | 2002 | N Engl J Med2002，347，16： | 1 |
| 14 | Neoadjuvant endocrine therapy of breast cancer : a surgical perspective 显示文摘 | Dixon JM Anderson TJ Miller WR | 2002 | Eur J Cancer2002，38，17： | 1 |
| 15 | Invasive cribriform carcinoma of the breast显示文摘 | Page DL Dixon JM Anderson TJ | 1983 | Histopathology1983，7，： | 1 |
| 16 | Assessment and treatment of endothelium dysfunction in humans显示文摘 | Anderson TJ | 1999 | JACC1999，34，3： | 1 |
| 17 | The ten most commonly asked question about endothelial function in cardiology显示文摘 | Verrna S Anderson TJ | 2001 | Cardiology Rev2001，20，2： | 1 |
| 18 | Close relation of endothelial function in the human coronary and peripheral circulations 显示文摘 | Anderson TJ Uehata A Gerhard MD | 1995 | J Am Coil Cardiol1995，26，5： | 1 |
| 19 | Insulin action in the vasculature:physiology and pathophysiology显示文摘 | Mather K Anderson TJ Verma S | 2001 | J Vasc Res2001，38，5： | 1 |
| 20 | Close relation of endothedial functionin the human coronary and periphend circula-tion显示文摘 | Anderson TJ Uehata A Gerhard MD | 1995 | J Am Coil Cardiol1995，26，： | 1 |
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