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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 4 | Activation of the Complement System During and After Cardiopulmonary Bypass Surgery: Postsurgery Activation Involves C-Reactive Protein and Is Associated With Postoperative Arrhythmia显示文摘 | Peter Bruins Henk te Velthuis Aria P. Yazdanbakhsh Piet G.M. Jansen Fred W.J. van Hardevelt Eddy M.F.H. de Beaumont Charles R.H. Wildevuur Leon Eijsman NA Trouwborst C. Erik Hack | 1997 | Circulation1997，，10： | 2 |
| 5 | Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis显示文摘 | Caplice NM Panetta C Peter son TE | 2001 | Blood2001，98，10： | 1 |
| 6 | COX-2 polymorphisms and the risk for head and neck cancer in white patients 显示文摘 | Peters WH Lacko M Te Morsche RH | 2009 | Head Neck2009，31，： | 1 |
| 7 | Neuroprotection by a novel compound,NS521 显示文摘 | Gronborg M Johansen TE Peters D | 1999 | J Pharmacol Exp Ther1999，290，： | 1 |
| 8 | Heterologous protein expression in filamentous fungi显示文摘 | K.M. Helena Nevalainen Valentino S.J. Te’o Peter L. Bergquist | 2005 | Trends in Biotechnology2005，，9： | 1 |
| 9 | Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells 显示文摘 | Tao X Hill TE Morimoto C Peters CA Ksiazek TG Tseng CT | 2013 | J Viroh2013，87，17： | 1 |
| 10 | Library consortia in Germany显示文摘 | Werner Reinhardt & Peter Te Boehorst | 2001 | Liber Quarterly2001，，11： | 1 |
| 11 | Clinical outcome of Crohn?s disease according to the Vienna classification: disease location is a useful predictor of disease course显示文摘 | Liekele E. Oostenbrug Hendrik M. van Dullemen Gerard J. te Meerman Peter L.M. Jansen Jan H. Kleibeuker | 2006 | European Journal of Gastroenterology & Hepatology2006，，3： | 1 |
| 12 | Systematics of the Genus Geothelphusa (Crustacea, Decapoda, Brachyura, Potamidae) from Southern Taiwan:a Molecular Appraisal显示文摘 | Hsi Te Shih Peter K L Huang W C | 2004 | Zoolog ical Studies2004，43，3： | 1 |
| 13 | EPHX1 polymorphisms do not modify esophageal carcinoma susceptibilityin Dutch Caucasians显示文摘 | Polat Dura Caro Bregitha Rene Te Morsche Hennie Roelofs Jon Kristinsson Theo Wobbes Ben Witteman Adriaan Tan Joost Drenth Wilbert Peters | 2012 | Oncology Reports2012，，6： | 1 |
| 14 | The diagnostic accuracy of urine-based X-pert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce显示文摘 | Peter JG Theron G Muchinga TE | 2012 | PLos One2012，7，39： | 1 |
| 15 | Renal Heterotransplantation from Baboon to Man: Experience with 6 Cases显示文摘 | Starzl TE Marchioro TL Peters GN | 1964 | Transplantation1964，2，： | 1 |
| 16 | Network system forautomated seizure detection and contingent delivery of thera-py显示文摘 | Peters TE Bhavraju NC Frei MG | 2001 | J Clin Neurephysiol2001，18，： | 1 |
| 17 | Neuroprotection by a novel compound,NS521显示文摘 | Gronborg M Johansen TE Peters D | 1999 | J Pharmacol Exp Ther1999，290，1： | 1 |
| 18 | Laboratory diagnosis of Nipah and Hendra vires infections显示文摘 | Peter D Thomas K Bryan TE | 2001 | Microbes Infect2001，3，： | 1 |
| 19 | Misconceptions about falling sperm counts and fertility in Europe显示文摘 | Egbert R te Velde Jens Peter Bonde | 2013 | Asian Journal of Andrology2013，15，2： | 1 |
| 20 | Comorbidity of alcohol and substance dependence with attention - deficit/hyperactivity disorder ( ADHD ) 显示文摘 | Ohlmeier MD Peters K Te Wildt BT | 2008 | Alcohol Alcohol2008，43，3： | 1 |
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