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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | 人工全膝关节置换术截骨测量(英文)显示文摘[目的]作者对人工全膝关节置换术中股骨截骨方法进行了改良,增加了股骨后髁截骨厚度,本项研究通过截骨厚度的测量对改良截骨方法的手术效果进行了验证。[方法]对81例人工全膝关节置换术中的各向截骨骨块的厚度进行了测量,分为膝内翻和膝外翻两组,采用Student's t-test对截骨厚度和假体厚度进行了比较。[结果]总体截骨厚度在膝间隙和伸膝间隙均小于假体厚度。膝内翻组,外侧屈膝间隙存在微量的过度截骨;膝外翻组,内侧屈膝间隙存在微量的过度截骨。[结论]采用改良的股骨截骨方法,手术效果良好。 | 孙水 Udo Malzer Peter Schuler | 2008 | 中国矫形外科杂志2008，16，2： | 2 |
| 3 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 4 | 2-Year Follow-Up of Patients Undergoing Transcatheter Aortic Valve Implantation Using a Self-Expanding Valve Prosthesis显示文摘 | Lutz Buellesfeld Ulrich Gerckens Gerhard Schuler Raoul Bonan Jan Kovac Patrick W. Serruys Marino Labinaz Peter den Heijer Michael Mullen Wayne Tymchak Stephan Windecker Ralf Mueller Eberhard Grube | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 5 | An Integrative Frameworks of Strategic International Human Resource Management 显示文摘 | Schuler R S Peter J Dowling Helen DeCieril | 1992 | International Journal of Human Resource Management1992，，12： | 1 |
| 6 | Strategic performance measurement and management in multinational Corporations显示文摘 | Randall S Schuler John R Fulkerson and Peter J Dowling | 1991 | Human Resource Management1991，30，3： | 1 |
| 7 | MDR1 and ERCC1 Expression Predict Outcome of Patients with Locally Advanced Bladder Cancer Receiving Adjuvant Chemotherapy显示文摘 | Andreas-Claudius Hoffmann Peter Wild Christina Leicht Simone Bertz Kathleen D. Danenberg Peter V. Danenberg Robert St?hr Michael St?ckle Jan Lehmann Martin Schuler Arndt Hartmann | 2010 | Neoplasia2010，，： | 1 |
| 8 | 人工全膝关节置换术股骨截骨方法改良及效果显示文摘目的对人工全膝关节置换术股骨截骨方法进行改良,通过截骨厚度的测量和临床随访对改良截骨方法的手术效果进行评估。方法改良股骨截骨模板,股骨后髁截骨厚度增加3mm。对81例人工全膝关节置换术中的各向截骨厚度进行测量,分为膝内翻和膝外翻两组,对截骨厚度和假体厚度进行比较分析。术后平均随访27.1个月。结果全组患者屈膝间隙和伸膝间隙平均截骨厚度均小于假体厚度。膝内翻和膝外翻组间除股骨后髁内侧截骨厚度外,各项测量值间差异均存在显著性意义(P<0.01)。膝内翻组内侧屈伸膝间隙截骨厚度和假体厚度差异最大;膝外翻组,外侧屈伸膝间隙截骨厚度和假体厚度差异最大。膝内翻组,外侧屈膝间隙存在过度截骨(0.57mm);膝外翻组,内侧屈膝间隙存在过度截骨(0.92mm)。术后关节活动度良好,仅7%的患者存在轻度屈膝不稳,无中重度不稳。结论对股骨截骨模板的改良是可行的,股骨后髁截骨厚度增加3mm不会出现过度截骨和屈膝不稳的情况。 | 孙水 Udo Malzer Peter Schuler | 2004 | 中华创伤杂志2004，20，11： | 1 |
| 9 | MAGE-A3 is a frequent tumor antigen of metastasized melanoma显示文摘 | Claudia Roeder Beatrice Schuler-Thurner Susanne Berchtold Gisela Vieth Peter von den Driesch Gerold Schuler Matthias Lüftl | 2005 | Archives of Dermatological Research2005，，7： | 1 |
| 10 | Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial显示文摘 | Holger Thiele Jochen W?hrle Rainer Hambrecht Harald Rittger Ralf Birkemeyer Bernward Lauer Petra Neuhaus Oana Brosteanu Peter Sick Marcus Wiemer Sebastian Kerber Klaus Kleinertz Ingo Eitel Steffen Desch Gerhard Schuler | 2012 | The Lancet2012，，9819： | 1 |
| 11 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences显示文摘 | STRAUSBERG R L FEINGOLD E A GROUSE L H DERGE J G KLAUSNER R D COLLINS F S WAGNER L SHENMEN C M SCHULER G D ALTSCHUL S F ZEEBERG B BUETOW K H SCHAEFER C F BHAT N K HOPKINS R F JORDAN H MOORE T MAX S I WANG J HSIEH F DIATCHENKO L MARUSINAK FARMER A A RUBIN G M HONG L STAPLETON M SOARES M B BONALDO M F CASAVANT T L SCHEETZ T E BROWNSTEIN M J USDIN T B TOSHIYUKI S CARNINCI P PRANGE C RAHA S S LOQUELLANO N A PETERS G J ABRAMSON R D MULLAHY S J BOSAK S A MCEWAN P J MCKERNAN K J MALEK J A GUNARATNE P H RICHARDS S WORLEY K C HALE S GARCIA A M GAY L J HULYK S W VILLALON D K MUZNY D M SODERGREN E J LU X GIBBS R A FAHEY J KETTEMAN M MADAN A RODRIGUES S SANCHEZ A WHITING M YOUNG A C SHEVCHENKO Y BOUFFARD G G BLAKESLEY R W TOUCHMAN J W GREEN E D DICKSON M C RODRIGUEZ A C GRIMWOOD J SCHMUTZ J MYERS R M BUTTERFIELD Y S KRZYWINSKI M I SKALSKA U SMAILUS D E SCHNERCH A SCHEIN J E JONES S J MARRA M A | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 12 | Left Atrial Appendage Closure with the Watchman Device in Patients with a Contraindication for Oral Anticoagulation: ASA Plavix Feasibility Study with Watchman Left Atrial Appendage Closure Technology (ASAP Study)显示文摘 | Vivek Y. Reddy Sven M?bius-Winkler Marc A. Miller Petr Neuzil Gerhard Schuler Jens Wiebe Peter Sick Horst Sievert | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 13 | Initial Worldwide Experience With the WATCHMAN Left Atrial Appendage System for Stroke Prevention in Atrial Fibrillation显示文摘 | Peter B. Sick Gerhard Schuler Karl Eugen Hauptmann Eberhard Grube Steve Yakubov Zoltan G. Turi Gregory Mishkel Steve Almany David R. Holmes | 2007 | Journal of the American College of Cardiology2007，，13： | 1 |
| 14 | 人工膝关节表面置换术截骨方法的改良显示文摘对股骨截骨模板进行了改良 ,股骨后髁截骨厚度增大了 3mm。试行人工全膝关节置换术 81例 ,术后平均随访 17个月。结果 :术后关节稳定性良好 ,手术后患者膝关节活动范围、最大屈曲角度、伸直缺滞均较术前明显改善 ,术后下肢力线满意。认为这一改良的股骨截骨方法效果良好 。 | 孙水 Udo Malzer Peter Schuler | 2001 | 山东医药2001，41，16： | 0 |
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