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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Mesenchymal stem cell tracking in the intervertebral disc显示文摘Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc(IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management,including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging(MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD. | Charles Handley Tony Goldschlager David Oehme Peter Ghosh Graham Jenkin | 2015 | World Journal of Stem Cells2015，7，1： | 1 |
| 3 | Role of Raman spectroscopy and surface enhanced Raman spectroscopy in colorectal cancer显示文摘Colorectal cancer(CRC) is the fourth most commoncancer in the United Kingdom and is the second largest cause of cancer related death in the United Kingdom after lung cancer.Currently in the United Kingdom there is not a diagnostic test that has sufficient differentiation between patients with cancer and those without cancer so the current referral system relies on symptomatic presentation in a primary care setting.Raman spectroscopy and surface enhanced Raman spectroscopy(SERS) are forms of vibrational spectroscopy that offer a nondestructive method to gain molecular information about biological samples.The techniques offer a wide range of applications from in vivo or in vitro diagnostics using endoscopic probes,to the use of micro-spectrometers for analysis of biofluids.The techniques have the potential to detect molecular changes prior to any morphological changes occurring in the tissue and therefore could offer many possibilities to aid the detection of CRC.The purpose of this review is to look at the current state of diagnostic technology in the United Kingdom.The development of Raman spectroscopy and SERS in clinical applications relation for CRC will then be discussed.Finally,future areas of research of Raman/SERS as a clinical tool for the diagnosis of CRC are also discussed. | Cerys A Jenkins Paul D Lewis Peter R Dunstan Dean A Harris | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 1 |
| 4 | Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells显示文摘 | Christopher Thomas Greg Ely David C. James Robert Jenkins Michael Kastan Anne Jedlicka Peter Burger Robert Wharen | 2001 | Acta Neuropathologica2001，，6： | 1 |
| 5 | Automatic classification of Web resources using Java and Dewey decimal classification显示文摘 | Jenkins Charlotte Jackson Mike Burden Peter | 1998 | ComputerNetworks & ISDN Systems1998，30，17： | 1 |
| 6 | The Competitive Growth of Flocforming and Filamentous Bacteria: a Model for Activated Sludge Bulking 显示文摘 | Antonia O Lau Peter F Strom David Jenkins | 1984 | Journal W PCF1984，56，1： | 1 |
| 7 | Ionic composition and transport mechanisms in microbial desalination cells显示文摘 | Haiping Luo Pei Xu Peter E. Jenkins Zhiyong Ren | 2012 | Journal of Membrane Science2012，，： | 1 |
| 8 | nSPARQL: A navigational language for RDF显示文摘 | Charlotte Jenkins Mike Jackson Peter BurdenJonWaUis | 2010 | Web Se- mantics:Science Services and Agents on the World Wide Web2010，，4： | 1 |
| 9 | Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats显示文摘 | Jenkins LW Peters GW Dixon CE | 2002 | J Neurotrauma2002，19，3： | 1 |
| 10 | Heterogeneous corrosion behaviour of carbon steel in water contaminated biodiesel显示文摘 | Wei Wang Peter E. Jenkins Zhiyong Ren | 2010 | Corrosion Science2010，，2： | 1 |
| 11 | Spatial patterns of food storage by Merriam's kangaroo rats显示文摘 | Jenkins S H Peters R A | 1992 | Behavioral Ecology1992，3，： | 1 |
| 12 | Surgical Strategy for Cystic Diseases of the Liver in a Western Hepatobiliary Center显示文摘 | Basil J. Ammori Benjamin L. Jenkins Phillip C.M. Lim K. Rajendra Prasad Stephen G. Pollard J. Peter A. Lodge | 2002 | World Journal of Surgery2002，，4： | 1 |
| 13 | nSPARQL:A navigational language for RDF显示文摘 | Charlotte Jenkins Mike Jackson Peter Burden JonWallis | 2010 | Web Seman- tics:Science Services and Aents on the World Wide Web2010，，4： | 1 |
| 14 | Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats显示文摘 | Jenkins LW Peters GW Dixon CE | 2002 | J Neurotrauma2002，19，6： | 1 |
| 15 | Diazonium Salt Derivatives of Osmium Bipyridine Complexes : Electrochemical Grafting and Characterisation of Modified Surfaces 显示文摘 | David J Garrett Peter Jenkins Matthew I J | 2011 | Electrochim Acta2011，56，： | 1 |
| 16 | A modular electrochemical sensor for saccharides显示文摘 | Ushiroda S Peter L M Jenkins A T A James T D | 2002 | Chem Commun2002，2368，： | 1 |
| 17 | Management of massive and submassive pulmonary embolism: focus on recent randomized trials 显示文摘 | Jenkins Peter O Sultanzadeh | 2014 | Curr Opin Pulm Med2014，20，5： | 1 |
| 18 | Automatic classification of Web resources using Java and Dewey Decimal Classification 显示文摘 | Jenkins Charlotte Jackson Mike Burden Peter | 1998 | Computer Networks and ISDN Systems1998，，4： | 1 |
| 19 | Electrochemical corrosion of carbon steel exposed to biodiesel/simulated seawater mixture显示文摘 | Wei Wang Peter E. Jenkins Zhiyong Ren | 2011 | Corrosion Science2011，，： | 1 |
| 20 | Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the prostate, lung, colorectal, and ovarian screening study显示文摘 | Flood A Peters U Jenkins DJ | 2006 | Am J Clin Nutr2006，84，5： | 1 |
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