|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome显示文摘BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and obesity.Both PCOS and NAFLD are more severe in South Asian women.Data on NAFLD in South Asian women with PCOS are lacking.AIM To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South Asia.METHODS We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per meter.Significant liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 kilopascals.Elevated alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian women.Biochemical hyperandrogenism was defined as free androgen index>5.Predictors of NAFLD were determined by logistic regression analysis.RESULTS 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were included.Prevalence of NAFLD and significant liver fibrosis was 39.6% and 6.9%,respectively.Elevated ALT was observed in 40%and 11.5%of patients with and without NAFLD,respectively.After adjusting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adjusted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and hyperandrogenism.Non-invasive screening strategies could help early diagnosis and initiation of interventions,including counselling on weight loss,cardiovascular risk stratification and linkage to hepatology care where appropriate. | Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes Philip Wong Tianyan Chen Giada Sebastiani | 2020 | World Journal of Gastroenterology2020，26，44： | 11 |
| 2 | Ectopic varices显示文摘 | Majid Abdulrahman Almadi Abdulqader Almessabi Philip Wong Peter M. Ghali Alan Barkun | 2011 | Gastrointestinal Endoscopy2011，，2： | 3 |
| 3 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 4 | Ectopic varices显示文摘 | Majid Abdulrahman Almadi Abdulqader Almessabi Philip Wong Peter M. Ghali Alan Barkun | 2011 | Gastrointestinal Endoscopy2011，，2： | 1 |
| 5 | Clostridium Difficile Colitis: Increasing Incidence, Risk Factors, and Outcomes in Solid Organ Transplant Recipients显示文摘 | Marylise Boutros Maha Al-Shaibi Gabriel Chan Marcelo Cantarovich Elham Rahme Steven Paraskevas Marc Deschenes Peter Ghali Philip Wong Myriam Fernandez Nadia Giannetti Renzo Cecere Mazen Hassanain Prosanto Chaudhury Peter Metrakos Jean Tchervenkov Jeffrey | 2012 | Transplantation Journal2012，，10： | 1 |
| 6 | Influence of Diabetes on Cardiac Resynchronization Therapy With or Without Defibrillator in Patients With Advanced Heart Failure显示文摘 | Jalal k. Ghali John Boehmer Arthur M. Feldman Leslie A. Saxon Teresa Demarco Peter Carson Patrick Yong Elizabeth G. Galle Jill Leigh Fred L. Ecklund Michael R. Bristow | 2007 | Journal of Cardiac Failure2007，，9： | 1 |
| 7 | Contrast-Induced Acute Kidney Injury and Risk of Adverse Clinical Outcomes After Coronary Angiography: A Systematic Review and Meta-Analysis显示文摘 | Matthew T. James Susan M. Samuel Megan A. Manning Marcello Tonelli William A. Ghali Peter Faris Merril L. Knudtson Neesh Pannu Brenda R. Hemmelgarn | 2013 | Circulation: Cardiovascular Interventions2013，，1： | 1 |
| 8 | Characterization of hepatitis B virus genotypes and quantitative hepatitis B surface antigen titres in North American tertiary referral liver centres显示文摘 | Stephen E. Congly Philip Wong Said A. Al‐Busafi Karen Doucette Scott K. Fung Peter Ghali Kevin Fonseca Robert P. Myers Carla Osiowy Carla S. Coffin | 2013 | Liver Int2013，，9： | 1 |
| 9 | Meta-Analysis of the Effectiveness and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Versus Without Left Ventricular Systolic Dysfunction显示文摘 | Stephen B. Wilton Adam Fundytus William A. Ghali George D. Veenhuyzen F. Russell Quinn L. Brent Mitchell Michael D. Hill Peter Faris Derek V. Exner | 2010 | The American Journal of Cardiology2010，，9： | 1 |
| 10 | Prevention and Management of Gastroesophageal Varices in Cirrhosis显示文摘 | Yen-I Chen Peter Ghali Averell Sherker | 2012 | International Journal of Hepatology2012，，： | 1 |
| 11 | Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography:A prospective study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and nonalcoholic steatohepatitis(NASH)seem common after liver transplantation.AIM To investigate incidence and predictors of NAFLD and NASH by employing noninvasive testing in liver transplant recipients,namely controlled attenuation parameter(CAP)and the serum biomarker cytokeratin 18(CK-18).We also evaluated the diagnostic accuracy of CK-18 and CAP compared to liver histology.METHODS We prospectively recruited consecutive adult patients who received liver transplant at the McGill University Health Centre between 2015-2018.Serial measurements of CK-18 and CAP were recorded.NAFLD and NASH were diagnosed by CAP≥270 dB/m,and a combination of CAP≥270 dB/m with CK-18>130.5 U/L,respectively.Incidences and predictors of NAFLD and NASH were investigated using survival analysis and Cox proportional hazards.RESULTS Overall,40 liver transplant recipients(mean age 57 years;70%males)were included.During a median follow-up of 16.8 mo(interquartile range 15.6-18.0),63.0%and 48.5%of patients developed NAFLD and NASH,respectively.On multivariable analysis,after adjusting for sex and alanine aminotransferase,body mass index was an independent predictor of development of NAFLD[adjusted hazard ratio(aHR):1.21,95%confidence interval(CI):1.04-1.41;P=0.01]and NASH(aHR:1.26,95%CI:1.06-1.49;P<0.01).Compared to liver histology,CAP had a 76%accuracy to diagnose NAFLD,while the accuracy of CAP plus CK-18 to diagnose NASH was 82%.CONCLUSION NAFLD and NASH diagnosed non-invasively are frequent in liver transplant recipients within the first 18 mo.Close follow-up and nutritional counselling should be planned in overweight patients. | Alshaima Alhinai Afsheen Qayyum-Khan Xun Zhang Patrick Samaha Peter Metrakos Marc Deschenes Philip Wong Peter Ghali Tian-Yan Chen Giada Sebastiani | 2021 | World Journal of Hepatology2021，13，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员