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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Costing for long-term care:The development of Scottish health service resource utilization groups as a case-mix instrument 显示文摘 | James U David CK Peter SM | 1999 | Age and Ageing1999，28，2： | 1 |
| 3 | Influence of Neoadjuvant Therapy with Epirubicin and Docetaxel on the Expression of HER2/neu in Patients with Breast Cancer显示文摘 | Susanne Taucher Margaretha Rudas Robert M. Mader Michael Gnant Emanuel Sporn Peter Dubsky Sebastian Roka Thomas Bachleitner Florian Fitzal Daniela Kandioler Catharina Wenzel Günther G. Steger Martina Mittlb?ck Raimund Jakesz | 2003 | Breast Cancer Research and Treatment2003，，3： | 1 |
| 4 | Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides显示文摘 | Tao YZ Zhang LN Peter CK | 2006 | Carbohydrate Research2006，341，： | 1 |
| 5 | PillCamColon2 after incomplete colonoscopy-A prospective multicenter study显示文摘AIM To evaluate the ability of PillCamColon2 to visualize colonic segments missed by incomplete optical colonoscopy(OC) and to assess the diagnostic yield.METHODS This prospective multicentre study included 81 patients from nine centres who underwent second-generation colon capsule endoscopy(CCE) following incomplete OC performed by an experienced gastroenterologist(> 1000 colonoscopies). Patients with stenosis were excluded. According to patient preferences, CCE was performed the following day(protocol A) after staying on clear liquids and 0.75 L Moviprep in the morning or within 30 d after new split-dose Moviprep(protocol B). Boosts consisted of 0.75 L and 0.25 L Moviprep, and phospho-soda was given as a rescue if the capsule was not excreted after seven hours.RESULTS Seventy-four patients were analysed(51% of them in group A; 49% in group B). Bowel cleansing was adequate in 67% of cases, and CCE could visualize colonic segments missed by incomplete colonoscopy in 90% of patients under protocol A and 97% of patients under protocol B(P = 0.35, n.s.). Significant polyps including adenocarcinoma were detected in 24% of cases. Detection rates for all polyps and significant polyps per patient were similar in both protocols. Polyps were found predominantly in the right colon(86%) in segments that were not reached by OC. Extracolonic findings-such as reflux esophagitis, suspected Barrett esophagus, upper GI-bleeding, gastric polyps, gastric erosions and angiectasia-were detected in eight patients. Pill Cam Colon2 capsule was retained in the ileum of one patient(1.4%) without symptoms and removed during an uneventful resection for unknown Crohn's disease that was diagnosed as the cause of anemia, which was the indication for colonoscopy. CCE was well tolerated. One patient suffered from selflimiting vomiting after consuming the phospho-soda.CONCLUSION Second-generation CCE using a low-volume preparation is useful after incomplete OC, and it allows for the detection of additional relevant findings, but cleansing efficiency could be improved. | Peter Baltes Marc Bota Jorg Albert Michael Philipper Hans-Georg Horster Friedrich Hagenmüller Ingo Steinbrück Ralf Jakobs Matthias Bechtler Dirk Hartmann Horst Neuhaus Jean-Pierre Charton Rupert Mayershofer Horst Hohn Thomas Rosch Stefan Groth Tanja Nowak Peter Wohlmuth Martin Keuchel | 2018 | World Journal of Gastroenterology2018，24，31： | 1 |
| 6 | Assay of blood acetaldehyde by HPLC with fluorescence detection of its 2-diphenylacetyl-1,3 -indanione-1-azine derivatives显示文摘 | Rideout JM Lim CK Peters TJ | 1986 | Clin Chim Acta1986，161，： | 1 |
| 7 | Evaluation of Sulfated Lentinus Edoses α(1→3)-D-Glucan as a Potential Antitumor Agent 显示文摘 | Zhang PY Peter CK | 2002 | Biosci Biotechnol Biochem2002，66，5： | 1 |
| 8 | Pathways from emotional adjustment to glycemic control in youths with diabetes in Hong Kong显示文摘 | Sunita MS Peter WH Louis CK | 2000 | Journal of Pediatric Psychology2000，25，6： | 1 |
| 9 | Lysozyme activity in rainbow trout,Oncorhynchus mykiss (Walbaum),stressed by handling,transport and water pollution显示文摘 | M(o)ck A Peters G | | 0，，06： | 1 |
| 10 | Activation Energy for the Self‐Metalation Reaction of 2H‐Tetraphenylporphyrin on Cu(111)显示文摘 | Stefanie Ditze Michael Stark Martin Drost Florian Buchner Hans‐Peter Steinrück Hubertus Marbach | 2012 | Angew. Chem. Int. Ed2012，，43： | 1 |
| 11 | Evaluation of Sulfated Lentinus Edoses α-(1→3)-l-Glucan as a Potential Antitumor Agent显示文摘 | Zhang PY Peter CK | 2002 | Biosci Biotechnol Biochem2002，66，5： | 1 |
| 12 | Peroxisome-proliferator-activated receptors γ and peroxisome-proliferator-activated receptors β/δ and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain显示文摘 | Torben Glatz Ivonne St?ck Miriam Nguyen-Ngoc Peter Gohlke Thomas Herdegen Juraj Culman Yi Zhao | 2010 | Journal of Hypertension2010，，7： | 1 |
| 13 | Prognostic markers in breast cancer: the reliability of HER2/neu status in core needle biopsy of 325 patients with primary breast cancer显示文摘 | Susanne Taucher MD Margaretha Rudas Robert M. Mader Michael Gnant Peter Dubsky Sebastian Roka Thomas Bachleitner Daniela Kandioler Günther Steger Martina Mittlb?ck Raimund Jakesz | 2004 | Wiener Klinische Wochenschrift (-)2004，，1： | 1 |
| 14 | Towards the development of a DNA - sequence based approach to serotyping of Salmonella enterica显示文摘 | Mortimer CK Peters TM Gharbia SE | 2004 | BMC Microbio12004，4，： | 1 |
| 15 | Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides显示文摘 | Tao YZ Zhang LN Peter CK | 2006 | Carbohydrate Res2006，341，： | 1 |
| 16 | Systemically expressed soluble Tie2 inhibits intraocular neovascularization显示文摘 | Hangai M Moon YS Kitaya N Chan CK Wu DY Peters KG | 2001 | Human Gene Therapy2001，12，： | 1 |
| 17 | Prospective navigator correction of image position for coronary MR angiography显示文摘 | Peter DD Michael VM Vaibhav CK | 1997 | Radiology1997，203，： | 1 |
| 18 | Antioxidant activity and total phenolics of edible mushroom extracts显示文摘 | LM CHEUNG PETER CK CHEUNG VINCENT EC OOI | 2003 | Food Chemistry2003，81，2： | 1 |
| 19 | Interdigestive cycling in chronic pancreatitis: Altered coordination among pancreatic secretion, motility, and hormones显示文摘 | Oreste Pieramico J.Enrique Dominguez-Mu?oz Daniel K. Nelson Wolfgang B?ck Markus Büchler Peter Malfertheiner | 1995 | Gastroenterology1995，，1： | 1 |
| 20 | Urine and faecal porphyrin profiles by reversed-phase high-performance liquid chromatography in the porphyrias显示文摘 | Lim CK Peters TJ | 1984 | Clin Chim Acta1984，139，： | 1 |
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