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| 1 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 2 | Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots显示文摘Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on demand.However,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven arduous.Access to linearly polarized photons is essential for various applications.In this report,a novel concept to directly generate linearly-polarized photons is presented.This concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the QDs.This growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter. | Anders Lundskog Chih-Wei Hsu K Fredrik Karlsson Supaluck Amloy Daniel Nilsson Urban Forsberg Per Olof Holtz Erik Janzen | 2014 | Light(Science & Applications)2014，3，1： | 4 |
| 3 | Serum C-Reactive Protein Concentration and Genotype in Relation to Ischemic Stroke Subtype显示文摘 | Claes Ladenvall Katarina Jood Christian Blomstrand Staffan Nilsson Christina Jern Per Ladenvall | 2006 | Stroke2006，，8： | 1 |
| 4 | Experimental friction evaluation of cylinder liner/piston ring contact 显示文摘 | Staffan Johanssou Per H Nilsson Robert Ohlsson | 2011 | Wear2011，271，2011： | 1 |
| 5 | A non-solvent approach for high-stiffness all-cellulose biocomposites based on pure wood cellulose显示文摘 | Helena Nilsson Sylvain Galland Per Tomas Larsson | 2010 | Composites Science and Technology2010，70，12： | 1 |
| 6 | Staying on Farms--An Ideological Background显示文摘 | Per A Ke Nilsson | 2002 | Annals of Tourism Research2002，，1： | 1 |
| 7 | Staying on Farms an Ideological Background显示文摘 | Per Ake Nilsson | 2002 | Annals of Tourism of Research2002，，1： | 1 |
| 8 | Staying on farms-An ideological background显示文摘 | | 2002 | Annals of Tourism Research2002，29，1： | 1 |
| 9 | Neurointensive care is justified in elderly patients with severe subarachnoid hemorrhage—an outcome and secondary insults study显示文摘 | Mats Ryttlefors Tim Howells Elisabeth Ronne-Engstr?m Pelle Nilsson Per Enblad | 2010 | Acta Neurochirurgica2010，，2： | 1 |
| 10 | Staying On Farms--An Ideological Back-ground显示文摘 | Per Ake Nilsson | 2002 | Annals of Tourism Research2002，29，1： | 1 |
| 11 | Hydrodynamic control of nitrogen and phosphorus turnover in an eutrophicated estuary in an eutrophicated estuary in the Baltic显示文摘 | Per Nilsson Mats Jansson | 2002 | Water Research2002，36，18： | 1 |
| 12 | Diminished Circadian Variation in Heart Rate Variability before Surgery in Patients Developing Postoperative Atrial Fibrillation显示文摘 | Lena Jidéus Mats Ericson Mats Stridsberg Leif Nilsson Per Blomstr?m Carina Blomstr?m-Lundqvist | 2001 | Scandinavian Cardiovascular Journal2001，，4： | 1 |
| 13 | Responses to family businesses to extreme seasonality in demand: the case of Bornholm, Denmark 显示文摘 | Donald Getz Per Ake Nilsson | 2004 | Tourism Management2004，25，： | 1 |
| 14 | Staying on Farms: An Ideological Background显示文摘 | Per Ake Nilsson | 2002 | A nnals of Tourism Research2002，29，1： | 1 |
| 15 | Staying On Farms: An Ideological BacKground显示文摘 | Per AKe Nilsson | 2002 | Annals of Tourism Research2002，，1： | 1 |
| 16 | Responses of family businesses to extreme seasonality in demand:the case of Bornholm,Denmark显示文摘 | Donald Getz Per Ake Nilsson | | 0，，01： | 1 |
| 17 | AZD 1080, a novel GSK 3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans显示文摘 | Biljana Georgievska Johan Sandin James Doherty Anette M?rtberg Jan Neelissen Anita Andersson Susanne Gruber Yvonne Nilsson P?r Sch?tt Per I. Arvidsson Sven Hellberg Gunilla Osswald Stefan Berg Johanna F?lting Ratan V. Bhat | 2013 | J Neurochem2013，，3： | 1 |
| 18 | Particle Therapy – A next logical step in the improvement of radiotherapy显示文摘 | H?kan Nystr?m Erik Blomqvist Morten H?yer Anders Montelius Ludvig Paul Muren Per Nilsson Zahra Taheri-Kadkhoda Bengt Glimelius | 2011 | Acta Oncologica2011，，6： | 1 |
| 19 | Responses of Family Businesses to Extreme Seasonality in Demand:the Case of Bornholm,Denmark显示文摘 | Donald Getz Per Ake Nilsson | 2004 | Tourism Management2004，，25： | 1 |
| 20 | New cylinder liner surfaces for low oil consumption显示文摘 | Staffan Johansson Per H. Nilsson Robert Ohlsson Cecilia Anderberg Bengt-G?ran Rosén | 2008 | Tribology International2008，，9： | 1 |
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