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| 1 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 2 | Improvement of thermal stability of nickel germanide using nitrogen plasma pretreatment for germanium-based technology显示文摘Dear editor,Ge has been considered as a very promising candidate as a channel material of MOSFET to extend Moore’s law beyond sub-7 nm node, due to its high and symmetric mobility, as well as the compatibility with conventional Si process [1, 2].In spite of higher carrier mobility than Si, there are still several challenges for Ge MOSFETs, such as low electrical concentration of n-type dopants and high electron Schottky barrier height, resulting in large source/drain (S/D) series resistance. | Bingxin ZHANG Xia AN Pengqiang LIU Xiangyang HU Ming LI Xing ZHANG Ru HUANG | 2018 | Science China(Information Sciences)2018，61，10： | 1 |
| 3 | Ge surface passivation by GeO_2 fabricated by N_2O plasma oxidation显示文摘In this paper, Ge surface passivation by Ge O2 grown by N2 O plasma oxidation is presented and experimentally demonstrated. Results show that stoichiometrically Ge O2 can be achieved by N2 O plasma oxidation at 350°C. The transmission electron microscope observation reveals that the Ge O2/Ge interface is automatically smooth and the thickness of Ge O2is~0.9 nm with 120 s N2 O plasma oxidation. The interface state density of Ge surface after N2 O plasma passivation is about~3×1011 cm-2e V-1. With Ge O2 passivation,the hysteresis of MOS capacitor with Al2O3 as gate dielectric is reduced to~55 m V, compared to 130 m V of the untreated one. The Fermi-level at Ge O2/Ge interface is unpinned, and the surface potential is effectively modulated by the gate voltage, which is promising for high performance NMOSFETs fabrication. | LIN Meng AN Xia LI Ming YUN QuanXin LI Min LI Zhi Qiang LIU PengQiang ZHANG Xing HUANG Ru | 2015 | Science China(Information Sciences)2015，58，4： | 1 |
| 4 | Construction Method of Ideological and Political Theories Teaching in the Course of Environmental Microbiology for Environmental and Ecological Engineering Major显示文摘Environmental Microbiology is a professional basic course in the curriculum system of Environmental and Ecological Engineering major,which follows the requirements of ideological and political theories teaching in the course in higher education,and should be implemented in every course.Therefore,the construction of ideological and political theories teaching in the course should be an important task in the course construction of Environmental Microbiology.In view of the curriculum characteristics of Environmental Microbiology,such as multi-disciplinary feature,wide coverage and rapid development,it is an effective method for the construction of ideological and political theories teaching in the course of Environmental Microbiology by fully tapping the ideological and political elements of the curriculum,such as patriotism,scientific spirit and practical innovation,and integrating the ideological and political theories teaching in the course into the whole curriculum design and classroom teaching construction. | Weishuang TONG Yanjiao LI Jiafei SU Xining GENG Guang QI Pengqiang YAO Zhilu ZHANG | 2023 | Asian Agricultural Research2023，15，12： | 0 |
| 5 | Research and Exploration on Ideological and Political Theories Teaching in the Course of Soil Science Experiment:Taking Pingdingshan University as an Example显示文摘Experimental course is an important link of ideological and political education in colleges and universities under the new situation,and plays an important role in the construction of ideological and political theories teaching in the course.Taking Pingdingshan University as an example,by introducing the real soil cases in Pingdingshan area,the ideological and political elements of the course are integrated into the teaching links of laboratory safety training,self-study before class,experimental teaching implementation,evaluation and improvement.By implementing the concept of'All-round Education'in experimental teaching,we are committed to realizing the comprehensive coverage of value shaping,knowledge inheritance and ability training,and explore and practice the reform of ideological and political theories teaching in the course of Soil Science Experiment. | Xining GENG Yanjiao LI Weishuang TONG Shiping CHENG Pengqiang YAO Fengqin HUANG | 2023 | Asian Agricultural Research2023，15，12： | 0 |
| 6 | cDNA-SCoT Analysis of Differential Expressed Genes in Allium tuberosum Induced by Botrytis cinerea显示文摘[Objectives]To investigate the molecular mechanism of gene differential expression in A.tuberosum under Botrytis cinerea stress.[Methods]The leaf of A.tuberosum was inoculated with B.cinerea to induce resistance,then leaf samples were taken at 2,4,8,12 and 24 h,respectively,after inoculation,and used for cDNA-SCoT analysis to detect the gene differential expressions.[Results]More than 800 bands with length of 100-1800 bp were obtained using 60 SCoT primers.A total of 40 differentially expressed EST sequences were screened out,and 18 non-redundant ESTs with high quality were obtained by cluster analyses of the ESTs sequencing.The results of BlastN showed that the differential genes of A.tuberosum mainly related to disease defense,signal transduction,and protein metabolism.[Conclusions]Further analysis of gene function indicated that brassinosteroid biosynthesis-like proteins,NBS-LRR type disease resistance protein,jasmonic acid induced protein,abscisic stress ripening protein may be involved in the process of the incompatible interaction between the A.tuberosum and B.cinerea. | Minghui CHEN Zhilu ZHANG Yanjiao LI Pengqiang YAO Shiping CHENG Ganqing ZHAO | 2020 | Asian Agricultural Research2020，12，10： | 0 |
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