|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | First experimental demonstration of coherent beam combining of more than 100 beams显示文摘Coherent beam combining of 107 beams has been demonstrated for the first time to the best of our knowledge.When the system was in closed loop,the pattern in far-field was stable and the fringe contrast was>96%.The impact of the dynamic tilt error,the piston error,and power inconsistency was theoretically analyzed.Meanwhile,the distribution law of dynamic tilt error was estimated and the correlation of the tilt dithering of different axis was analyzed statistically.The ratio of power in the central lobe was^22.5%.The phase residue error in the closed loop was~λ∕22,which was evaluated by the root-mean-square error of the signal generated from the photoelectric detector. | HONGXIANG CHANG QI CHANG JIACHAO XI TIANYUE HOU RONGTAO SU PENGFEI MA JIAN WUCAN LI MAN JIANG YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，12： | 17 |
| 2 | Deep-learning-based phase control method for tiled aperture coherent beam combining systems显示文摘We incorporate deep learning(DL)into tiled aperture coherent beam combining(CBC)systems for the first time,to the best of our knowledge.By using a well-trained convolutional neural network DL model,which has been constructed at a non-focal-plane to avoid the data collision problem,the relative phase of each beamlet could be accurately estimated,and then the phase error in the CBC system could be compensated directly by a servo phase control system.The feasibility and extensibility of the phase control method have been demonstrated by simulating the coherent combining of different hexagonal arrays.This DL-based phase control method offers a new way of eliminating dynamic phase noise in tiled aperture CBC systems,and it could provide a valuable reference on alleviating the long-standing problem that the phase control bandwidth decreases as the number of array elements increases. | Tianyue Hou Yi An Qi Chang Pengfei Ma Jun Li Dong Zhi Liangjin Huang Rongtao Su Jian Wu Yanxing Ma Pu Zhou | 2019 | High Power Laser Science and Engineering2019，7，4： | 10 |
| 3 | Vertically aligned reduced graphene oxide/Ti_(3)C_(2)T_(x)MXene hybrid hydrogel for highly efficient solar steam generation显示文摘Effective utilization of abundant solar energy for desalination of seawater and purification of wastewater is one of sustainable techniques for production of clean water,helping relieve global water resource shortage.Herein,we fabricate a vertically aligned reduced graphene oxide/Ti_(3)C_(2)T_(x)MXene(A-RGO/MX)hybrid hydrogel with aligned channels as an independent solar steam generation device for highly efficient solar steam generation.The vertically aligned channels,generated by a liquid nitrogen-assisted directional-freezing process,not only rapidly transport water upward to the evaporation surface for efficient solar steam generation,but also facilitate multiple reflections of solar light inside the channels for efficient solar light absorption.The deliberate slight reduction endows the RGO with plenty of polar groups,decreasing the water vaporization enthalpy effectively and hence accelerating water evaporation efficiently.The MXene sheets,infiltrated inside the A-RGO hydrogel on the basis of Marangoni effect,enhance light absorption capacity and photothermal conversion performance.As a result,the A-RGO/MX hybrid hydrogel achieves a water evaporation rate of 2.09 kg·m^(−2)·h^(−1)with a high conversion efficiency of 93.5%under 1-sun irradiation.Additionally,this photothermal conversion hydrogel rapidly desalinates seawater and purifies wastewater to generate clean water with outstanding ion rejection rates of above 99%for most ions. | Wei Li Xiaofeng Li Wei Chang Jing Wu Pengfei Liu Jianjun Wang Xi Yao Zhong-Zhen Yu | 2020 | Nano Research2020，13，11： | 10 |
| 4 | Deep-learning-assisted, two-stage phase control method for high-power mode-programmable orbital angular momentum beam generation显示文摘High-power mode-programmable orbital angular momentum(OAM)beams have received substantial attention in recent years.They are widely used in optical communication,nonlinear frequency conversion,and laser processing.To overcome the power limitation of a single beam,coherent beam combining(CBC)of laser arrays is used.However,in specific CBC systems used to generate structured light with a complex wavefront,eliminating phase noise and realizing flexible phase modulation proved to be difficult challenges.In this paper,we propose and demonstrate a two-stage phase control method that can generate OAM beams with different topological charges from a CBC system.During the phase control process,the phase errors are preliminarily compensated by a deep-learning(DL)network,and further eliminated by an optimization algorithm.Moreover,by modulating the expected relative phase vector and cost function,all-electronic flexible programmable switching of the OAM mode is realized.Results indicate that the proposed method combines the characteristics of DL for undesired convergent phase avoidance and the advantages of the optimization algorithm for accuracy improvement,thereby ensuring the high mode purity of the generated OAM beams.This work could provide a valuable reference for future implementation of high-power,fast switchable structured light generation and manipulation. | TIANYUE HOU YI AN QI CHANG PENGFEI MA JUN LI LIANGJIN HUANG DONG ZHI JIAN WU RONGTAO SU YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，5： | 8 |
| 5 | 3D Lamellar-Structured Graphene Aerogels for Thermal Interface Composites with High Through-Plane Thermal Conductivity and Fracture Toughness显示文摘Although thermally conductive graphene sheets are efficient in enhancing in-plane thermal conductivities of polymers,the resulting nanocomposites usually exhibit low through-plane thermal conductivities,limiting their application as thermal interface materials.Herein,lamellarstructured polyamic acid salt/graphene oxide(PAAS/GO)hybrid aerogels are constructed by bidirectional freezing of PAAS/GO suspension followed by lyophilization.Subsequently,PAAS monomers are polymerized to polyimide(PI),while GO is converted to thermally reduced graphene oxide(RGO)during thermal annealing at 300℃.Final graphitization at 2800℃ converts PI to graphitized carbon with the inductive effect of RGO,and simultaneously,RGO is thermally reduced and healed to high-quality graphene.Consequently,lamellar-structured graphene aerogels with superior through-plane thermal conduction capacity are fabricated for the first time,and its superior through-plane thermal conduction capacity results from its vertically aligned and closely stacked high-quality graphene lamellae.After vacuum-assisted impregnation with epoxy,the resultant epoxy composite with 2.30 vol% of graphene exhibits an outstanding through-plane thermal conductivity of as high as 20.0 W m^−1 K^−1,100 times of that of epoxy,with a record-high specific thermal conductivity enhancement of 4310%.Furthermore,the lamellar-structured graphene aerogel endows epoxy with a high fracture toughness,~1.71 times of that of epoxy. | Pengfei Liu Xiaofeng Li Peng Min Xiyuan Chang Chao Shu Yun Ding Zhong-Zhen Yu | 2021 | Nano-Micro Letters2021，13，2： | 7 |
| 6 | Formation of Poly(ε-caprolactone) Networks via Supramolecular Hydrogen Bonding Interactions显示文摘In this contribution, we reported a novel approach to crosslink poly(ε-caprolactone)(PCL) via supramolecular hydrogen bonding interactions. First, a series of octa-armed poly(ε-caprolactone) stars with polyhedral oligomeric silsesquioxane(POSS) cores were synthesized via the ring-opening polymerizations. Thereafter, the arm ends of organic-inorganic star-shaped PCLs were reacted with 2-(6-isocyanatohexylaminocarbonylamino)-6-methyl-4[1 H]-pyrimidinone to obtain 2-ureido-4[1 H]-pyrimidone(UPy)-terminated PCL stars.Notably, the UPy-terminated PCL stars were physically crosslinked, which was evidenced by means of dynamic mechanical thermal analysis(DMTA) and rheological analysis. Owing to the formation of the physically-crosslinked networks, the organic-inorganic PCL stars displayed significant shape memory properties with about 100% of shape recovery, which was in marked contrast to the PCL stars without UPy termini. | Sen Xu Pengfei Chang Bingjie Zhao Muhammad Adeel Sixun Zheng | 2019 | Chinese Journal of Polymer Science2019，37，3： | 5 |
| 7 | Experimental study on atomization characteristics and dust-reduction performance of four common types of pressure nozzles in underground coal mines显示文摘Pressure nozzle is commonly used in the dust-reduction techniques by spraying of underground coal mines.Based on the internal structure,the pressure nozzle can be divided into the following types:spiral channel nozzle,tangential flow-guided nozzle and X-swirl nozzle.In order to provide better guidance on the selection of nozzles for the coal mine dust-reduction systems by spraying,we designed comparing experiments to study the atomization characteristics and dust-reduction performance of four commonly used nozzles in the coal mine underground with different internal structures.From the experimental results on the atomization characteristics,both the tangential flow-guided nozzle and the X-swirl nozzle have high flow coefficients.The atomization angle is the largest in the spiral non-porous nozzle,and smallest in both the X-swirl nozzle and the spiral porous nozzle.The spraying range and the droplet velocity are inversely proportional to the atomization angle.When the water pressure is low,the atomization performance of the spiral non-porous nozzle is the best among the four types of nozzles.The atomization performance of the X-swirl nozzle is superior to other types when the water pressure is high.Under the high water pressure,the particle size of the atomized droplets is smallest in the X-swirl nozzle.Through the experiments on the dust-reduction performance of the four types of nozzles and the comprehensive analysis,the X-swirl nozzle is recommended for the coal mine application site with low water pressure in the dust-reduction system,while at the sites with high water pressure,the spiral non-porous nozzle is recommended,which has the lowest water consumption and obvious economic advantages. | Han Han Pengfei Wang Ronghua Liu Chang Tian | 2020 | International Journal of Coal Science & Technology2020，7，3： | 2 |
| 8 | Effect of surface nanocrystallization induced by fast multiple rotation rolling on hardness and corrosion behavior of 316L stainless steel显示文摘 | Chui Pengfei Sun Kangning Sun Chang | 2011 | Applied Surface Science2011，257，： | 1 |
| 9 | Tight sandstone reservoir sensitivity and damage mechanism analysis: A case study from Ordos Basin, China and implications for reservoir damage prevention显示文摘Analysis of reservoir sensitivity to velocity,water,salt,acid,alkali and stress is critical for reservoir protection.To study the tight sandstone reservoir sensitivity at different formation depths(effective stress)and formation water conditions(pH,salinity,and fluid velocity),a series of dynamic core flow tests under different pH,salinity,acid,and effective stress conditions were performed on samples from tight sandstone reservoirs of the Upper Triassic Yanchang 8(T_(3)y^(8))Member and conventional reservoirs of the Middle-Lower Jurassic Yan'an 9(J_(1-2)y^(9))Member in the Ordos Basin.The results indicate that,compared with the conventional reservoirs,the tight sandstone reservoirs are more sensitive to velocity and stress,less sensitive to water,alkali and salinity,and respond better to acid fracturing.In addition,the critical conditions(salinity,velocity,pH,and stress)for pumping drilling,completion,and fracturing fluids into tight sandstone reservoirs were investigated.A combination of scanning electron microscopy coupled with energy-dispersive spectrometry(SEM-EDS),cathodoluminescence(CL),casting thin section(CTS)and nuclear magnetic resonance(NMR)images,high-pressure mercury injection capillary pressure(MICP)measurements as well as X-ray fluorescence spectral(XRF)analyses were employed to analyze the damage mechanisms of the conventional reservoirs(J_(1-2)y^(9))and tight sandstone reservoirs(T_(3)y^(8))caused by fluid invasion.The results suggest that reservoir sensitivity is primarily conditioned by the composition of detrital components and interstitial fillings,petrophysical properties,pore-throat structure,and diagenetic facies.All these factors control the sensitivity types and extent of the reser-voirs.Our results indicate that the poorer the reservoir physical properties,the stronger the reservoir heterogeneity and sensitivity,implying that tight sandstone reservoirs are more susceptible to changes in fluids than conventional reservoirs.This study offers insights into the reservoir damage types and helps to improve the design and implementation of protection measures for tight sandstone reservoir exploration. | Zhongquan Liu Bingbing Shi Tianchen Ge Fenggui Sui Yue Wang Pengfei Zhang Xiangchun Chang Ye Liu Yongrui Wang Zhaoyang Wang | 2022 | Energy Geoscience2022，3，4： | 1 |
| 10 | Effect of surface nanocrystallization induced by fast multiple rotation rolling on mechanical properties of a low carbon steel显示文摘 | Chui Pengfei Sun Kangning Sun Chang | 2012 | Materials and Design2012，35，： | 1 |
| 11 | Effects of Dietary Protein and Lipid Levels on Growth Performance, Muscle Composition, Immunity Index and Biochemical Index of the Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Juvenile显示文摘The effects of different dietary protein and lipid levels on juvenile greenfin horse-faced filefish(Thamnaconus septentrionalis)was experimentally evaluated in a 56-day study.Fish(initial weight 6.47±0.56 g)were fed with nine different diet combinations containing three varying levels of protein(37%,43%,49%)and lipids(4%,7%,10%)in triplicates,where the protein-to-energy(P/E)ratios of the diets varied in the range of 19.17-26.99mgkJ−1.Results showed that fish fed diets containing 49%protein and 10%lipid exhibited significantly lower feed intake than those fed other diets.The weight gain of fish fed diets with 43%protein was significantly higher than that of fish fed 37%or 49%protein diets.While no significant change in weight gain was observed when lipid content was increased from 4%to 7%,weight gain decreased significantly when lipid increased from 7%to 10%.The protein efficiency ratio and feed efficiency were highest when the fish were fed the diet with 49%protein and 7%lipids.Muscle crude lipid content was positively correlated with dietary protein level regardless of lipid level.The diet of 43%protein or 7%lipids significantly reduced the activity of alanine aminotransferase and aspartate aminotransferase in liver.The contents of aspartate aminotransferase,superoxide dismutase and malondialdehyde were significantly increased from 4%to 10%lipids in plasma.The plasma total cholesterol and triglyceride contents were positively correlated with dietary lipid level at the same protein level.Our comprehensive analysis concluded that a diet with 43%protein and 7%lipid,with a P/E ratio of 23.07mgkJ−1,significantly promote the growth performance,feed utilization and health of juvenile greenfin horse-faced filefish. | XU Zhengxin ZHANG Pengfei CHANG Qing CHEN Siqing BIAN Li WANG Zhida | 2021 | Journal of Ocean University of China2021，20，5： | 1 |
| 12 | Genetically-engineered“all-in-one”vaccine platform for cancer immunotherapy显示文摘An essential step for cancer vaccination is to break the immunosuppression and elicit a tumor-specific immunity.A major hurdle against cancer therapeutic vaccination is the insufficient immune stimulation of the cancer vaccines and lack of a safe and efficient adjuvant for human use.We discovered a novel cancer immunostimulant,trichosanthin(TCS),that is a clinically used protein drug in China,and developed a well-adaptable protein-engineering method for making recombinant protein vaccines by fusion of an antigenic peptide,TCS,and a cell-penetrating peptide(CPP),termed an'allin-one'vaccine,for transcutaneous cancer immunization.The TCS adjuvant effect on antigen presentation was investigated and the antitumor immunity of the vaccines was investigated using the different tumor models.The vaccines were prepared via a facile recombinant method.The vaccines induced the maturation of DCs that subsequently primed CD8^(+)T cells.The TCS-based immunostimulation was associated with the STING pathway.The general applicability of this genetic engineering strategy was demonstrated with various tumor antigens(i.e.,legumain and TRP2 antigenic peptides)and tumor models(i.e.,colon tumor and melanoma).These findings represent a useful protocol for developing cancer vaccines at low cost and time-saving,and demonstrates the adjuvant application of TCSdan old drug for a new application. | Aihua Wu Yingzhi Chen Hairui Wang Ya Chang Meng Zhang Pengfei Zhao Yisi Tang Qin Xu Zhuangzhi Zhu Yang Cao Yongzhuo Huang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 13 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 14 | Ocean surface wind speed and direction retrievals from the SSM/I显示文摘 | CHANG Pengfei LI Li | 1998 | IEEE Transactions on Power Systems1998，36，6： | 1 |
| 15 | Single site catalyst with enzyme-mimic micro-environment for electroreduction of CO_(2)显示文摘Single site catalysts provide a unique platform for mimicking natural enzyme due to their tunable interaction between metal center and coordinated ligand.However,most works have focused on preparing structural and functional models of nature enzyme,with less reports also taking the local chemical environment,i.e.,functional/catalytic residues around the active site which is an essential feature of enzymes,into consideration.Herein,we report a Co-centered porphyrinic polymer containing the enzyme-mimic micro-environment,where the linker triazole over CoN4 site enables formation of hydrogen bond with the*COOH intermediate,thus promoting the electrocatalytic reduction of CO_(2).As-prepared catalyst achieves the CO_(2)-to-CO conversion of 5,788 h^(−1) turnover frequency value and near unit(~96%)faradaic efficiency at−0.61 V versus reversible hydrogen electrode.This strategy will bring new dimension of designing highly active single-site catalysts. | Chang Long Kaiwei Wan Xueying Qiu Xiaofei Zhang Jianyu Han Pengfei An Zhongjie Yang Xiang Li Jun Guo Xinghua Shi Hui Wang Zhiyong Tang Shaoqin Liu | 2022 | Nano Research2022，15，3： | 1 |
| 16 | Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the COVID-19 pandemic,has posed severe threats to global public health,highlighting an urgent need to understand its pathogenesis and to develop antiviral therapies.Both DNA and RNA viruses can modulate cell cycle progression to maximize their replication.1 However,the effects of SARS-CoV-2 on cell cycle progression remains largely unknown. | Liyan Sui Letian Li Yinghua Zhao Yicheng Zhao Pengfei Hao Xuerui Guo Wenfang Wang Guoqing Wang Chang Li Quan Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 17 | Physical-property cutoffs of tight reservoirs by field and laboratory experiments: a case study from Chang 6, 8–9 in Ordos Basin显示文摘Tight sandstone reservoirs are generally characterized by complex reservoir quality,non-Darcy flow,and strong heterogeneity.Approaches utilized for evaluating physical property cutoffs of conventional reservoirs maybe inapplicable.Thus,a comprehensive investigation on physical property cutoffs of tight sandstone reservoirs is crucial for the reserve evaluation and successful exploration.In this study,a set of evaluation approaches take advantage of field operations(i.e.,core drilling,oil testing,and wireline well logging data),and simulation experiments(i.e.,high-pressure mercury injection-capillary pressure(MICP)experiment,oil-water relative permeability experiment,nuclear magnetic resonance(NMR)experiment,and biaxial pressure simulation experiment)were comparatively optimized to determine the physical property cutoffs of effective reservoirs in the Upper Triassic Chang 6,Chang 8 and Chang 9 oil layers of the Zhenjing Block.The results show that the porosity cutoffs of the Chang 6,Chang 8,and Chang 9 oil layers are 7.9%,6.4%,and 8.6%,and the corresponding permeability are 0.08 mD,0.05 mD,and 0.09 mD,respectively.Coupled with wireline well logging,mud logging,and oil testing,the cut-off of the thickness of single-layer effective reservoirs are approximately 3.0 m,3.0 m,and 2.0 m,respectively.Depending on the cutoffs of critical properties,a superimposed map showing the planar distribution of the prospective targets can be mapped,which may delineate the effective boundary of prospective targets for petroleum exploration of tight sandstone reservoirs. | Bingbing SHI Xiangchun CHANG Zhongquan LIU Ye LIU Tianchen GE Pengfei ZHANG Yongrui WANG Yue WANG Lixin MAO | 2021 | Frontiers of Earth Science2021，15，2： | 0 |
| 18 | CO_(2) coordination-driven top-down synthesis of a 2D non-layered metal-organic framework显示文摘Combining the physical advantages of two-dimensional(2D)inorganic nanosheets and the modular design and programmed structure of metal-organic frameworks(MOFs),2D MOFs remain at the forefront of functional material research.Despite tremendous efforts,precise control in the synthesis of 2D nonlayered MOFs with predesigned topology for desired applications remains challenging.Success in the bottom-up synthesis of 2D nonlayered MOFs via ligand exchange motivated us to incorporate partial BTC(BTC=1,3,5-benzenetricarboxylate)ligand dissociation and CO_(2) capped coordination into the top-down treatment of bulk Cu-BTC MOF,leading to successful conversion of a 3D nonlayered network to a 2D Cu-based topological structure.Notably,a supercritical CO_(2)-containing solvent mixture is employed to provide the desired defect and coordination engineering.Thus,our work introduces a new top-down concept based on modulated synthesis to fabricate high-quality 2D nonlayered MOFs for the first time. | Yannan Zhou Pengfei Yan Suoying Zhang Yunxiao Zhang Hongwei Chang Xiaoli Zheng Jingyun Jiang Qun Xu | 2022 | Fundamental Research2022，2，5： | 0 |
| 19 | Mechanical behaviors of backfill-rock composites: Physical shear test and back-analysis显示文摘The shear behavior of backfill-rock composites is crucial for mine safety and the management of surface subsidence.For exposing the shear failure mechanism of backfill-rock composites,we conducted shear tests on backfill-rock composites under three constant normal loads,compared with the unfilled rock.To investigate the macro-and meso-failure characteristics of the samples in the shear tests,the cracking behavior of samples was recorded by a high-speed camera and acoustic emission monitoring.In parallel with the experimental test,the numerical models of backfill-rock composites and unfilled rock were established using the discrete element method to analyze the continuous-discontinuous shearing process.Based on the damage mechanics and statistics,a novel shear constitutive model was proposed to describe mechanical behavior.The results show that backfill-rock composites had a special bimodal phenomenon of shearing load-deformation curve,i.e.the first shearing peak corresponded to rock break and the second shearing peak induced by the broken of aeolian sand-cement/fly ash paste backfill.Moreover,the shearing characteristic curves of the backfill-rock composites could be roughly divided into four stages,i.e.the shear failure of the specimens experienced:stage I:stress concentration;stage II:crack propagation;stage III:crack coalescence;stage IV:shearing friction.The numerical simulation shows that the existence of aeolian sand-cement/fly ash paste backfill inevitably altered the coalescence type and failure mode of the specimens and had a strengthening effect on the shear strength of backfillrock composites.Based on damage mechanics and statistics,a shear constitutive model was proposed to describe the shear fracture characteristics of specimens,especially the bimodal phenomenon.Finally,the micro-and meso-mechanisms of shear failure were discussed by combining the micro-test and numerical results.The research can advance the better understanding of the shear behavior of backfill-rock composites and contribute to the safety of mining engineering. | Jie Xin Quan Jiang Fengqiang Gong Lang Liu Chang Liu Qiang Liu Yao Yang Pengfei Chen | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，3： | 0 |
| 20 | The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation显示文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a severe global health crisis;its structural protein envelope(E)is critical for viral entry,budding,production,and induction of pathology which makes it a potential target for therapeutics against COVID-19.Here,we find that the E3 ligase RNF5 interacts with and catalyzes ubiquitination of E on the 63rd lysine,leading to its degradation by the ubiquitin-proteasome system(UPS).Importantly,RNF5-induced degradation of E inhibits SARS-CoV-2 replication and the RNF5 pharmacological activator Analog-1 alleviates disease development in a mouse infection model.We also found that RNF5 is distinctively expressed in different age groups and in patients displaying different disease severity,which may be exploited as a prognostic marker for COVID-19.Furthermore,RNF5 recognized the E protein from various SARS-CoV-2 strains and SARS-CoV,suggesting that targeting RNF5 is a broad-spectrum antiviral strategy.Our findings provide novel insights into the role of UPS in antagonizing SARS-CoV-2 replication,which opens new avenues for therapeutic intervention to combat the COVID-19 pandemic. | Zhaolong Li Pengfei Hao Zhilei Zhao Wenying Gao Chen Huan Letian Li Xiang Chen Hong Wang Ningyi Jin Zhao-Qing Luo Chang Li Wenyan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员