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| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 2 | Immunological battlefield in gastric cancer and role of immunotherapies显示文摘Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient's immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an 'us against them' model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy – the tumour cell. | Minyu Wang Rita A Busuttil Sharon Pattison Paul J Neeson Alex Boussioutas | 2016 | World Journal of Gastroenterology2016，22，28： | 4 |
| 3 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 4 | Factors associated with 5-year survival of combined hepatocellular and cholangiocarcinoma显示文摘BACKGROUND Combined hepatocellular and cholangiocarcinoma(HCC/CC)is a rare primary hepatic malignancy which carries a poor prognosis due to its aggressive nature.Few centers have enough cases to draw definitive conclusions and there is limited understanding of prognosis.Given the rarity of HCC/CC,an analysis of large national cancer database was needed to obtain larger number of HCC/CC cases.AIM To identify associated factors for 5-year survival of HCC/CC.METHODS We conducted a retrospective study of The Surveillance,Epidemiology,and End Results(SEER)database obtained from SEER*Stat 8.3.6 software.Previously defined histology code 8180 for the International Classification of Disease for Oncology,3rd edition was used to identify HCC/CC cases from 2004 to 2015.We collected demographics,American Joint Committee on Cancer(AJCC)stage,treatment,tumor size,and survival data.These data were converted to categorical variables.The Shapiro-Wilk normality test was used to assess normal distribution.Mann-Whitney U test was used to compare continuous variables without normal distribution,and t-test was used to compare continuous variables with a normal distribution.The Kaplan-Meier survival curve analyzed 5-year survival.Univariate and multivariate logistic regression model was used to analyze factors associated with 5-year survival.Multivariate Cox proportional hazard regression was done on 5-year survival.We defined P<0.05 was statistically significant.RESULTS We identified 497 patients with the following characteristics:Mean age 62.4 years(SD:11.3),149(30.0%)were female,racial distribution was:276(55.5%)white,53(10.7%)black,84(16.9%)Asian and Pacific Islander(API),77(15.5%)Hispanic,and 7(1.4%)others or unknown.Stage I/II disease occurred in 41.5%and tumor size<50 mm was seen in 35.6%of patients.Twenty-four(4.8%)received locoregional therapy(LRT),119(23.9%)underwent resection,and 50(10.1%)underwent liver transplantation.The overall median survival was 6 mo[Interquartile range(IQR):1-22].After multivariate logistic regression,tumor size<50 mm[Odds ratios(OR):2.415,P=0.05],resection(OR:12.849,P<0.01),and transplant(OR:27.129,P<0.01)showed significance for 5-year survival.Age>60,sex,race,AJCC stages,metastasis,and LRT were not significant.However,API vs white showed significant OR of 2.793(CI:1.120-6.967).Cox proportional hazard regression showed AJCC stages,tumor size<50 mm,LRT,resection,and transplant showed significant hazard ratio.CONCLUSION HCC/CC patients with tumor size<50 mm,resection,and transplant were associated with an increase in 5-year survival.API showed advantageous OR and hazard ratios over white,black. | Tomoki Sempokuya Eric A Wien Robert J Pattison Jihyun Ma Linda L Wong | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 5 | Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications显示文摘 | Pattison M A Wurster S Webster T J | 2005 | Biomaterials2005，26，15： | 1 |
| 6 | Three- dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications显示文摘 | Pattison M A Wurster S Webster T J | 2005 | Biomaterials2005，26，15： | 1 |
| 7 | Chromium(Ⅵ) reduction by catechol(amine)s results in DNA cleavage in vitro: Relevance to chromium genotoxicity显示文摘 | Pattison DI Davies MJ Levina A Dixon NE Lay PA | 2001 | Chemical Research in Toxicology2001，14，5： | 1 |
| 8 | Development of the vasculature of the anterior pituitary: ontogeny of basic fibroblast growth factor显示文摘 | Pattison A Pattison T | 1993 | Dev Dyn1993，197，2： | 1 |
| 9 | Neural network for quadratic optimization with bound constraints显示文摘 | Bouzerdoum A Pattison T R | 1993 | IEEE Transactions on Neural Networks1993，4，2： | 1 |
| 10 | Standoff distance and bow shock phenomena in the cold spray process 显示文摘 | Pattison J Celotto S Khan A | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 11 | N-glycan production in the endoplasimic reticulum of plant显示文摘 | Pattison R J Amtmann A | 2008 | Trends Plant Sci2008，14，： | 1 |
| 12 | Neural network for quadratic optimization with bound constraints 显示文摘 | Bouzerdorm A Pattison T R | 1993 | IEEE Trans on Neural Networks1993，4，3： | 1 |
| 13 | N-glycan production in the endoplasmic reticulum of plants 显示文摘 | Pattison R J Amtmann A | 2009 | Trends Plant Science2009，14，2： | 1 |
| 14 | New specifications for exponential random graph models 显示文摘 | Snijders T A Pattison P E Robins G L | 2006 | Sociological Methodology: (S1467-9531)2006，36，1： | 1 |
| 15 | Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction 显示文摘 | Roberts LM Pattison H Roalfe A | 2006 | Ann Intern Med2006，145，8： | 1 |
| 16 | Neural network for quadratic optimization with bound constraints显示文摘 | BOUZERDORM A PATTISON T R | 1993 | IEEE Trans on Neural Networks1993，4，4： | 1 |
| 17 | Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds显示文摘 | PATTISON M A PARK K | 2005 | Biomaterials2005，，26： | 1 |
| 18 | EPR studies of chromium(V) intermediates generated via reduction of chromium(VI) by DOPA and related catechol(amine)s:potential role for oxidized amino acids in chromium-induced cancers显示文摘 | Lay P A Davies M J | 2000 | Inorg Chem2000，39，： | 1 |
| 19 | Recurrent miscarriage-outcome after supportive care in early pregnancy显示文摘 | Liddell HS Pattison NS Zanderigo A | 1991 | Aust N Z J Obstet Gynaecol1991，31，4： | 1 |
| 20 | Beyond chemical dependency for managing plant-para,itic nematodes:examples from the banana,pineapple and vegetable industries of tropical and subtropical Australia显示文摘 | Stirling G R Pattison A B | | 0，，： | 1 |
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