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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | The physical map of the human RET proto-oncogene显示文摘 | PASINI B HOFSTRA R M YIN L | | 0，，09： | 1 |
| 3 | Genetics of epilepsyand rele?vance to current practice显示文摘 | Michelucci R Pasini E Riguzzi P | 2012 | Curr Neurol Neurosci Rep2012，12，4： | 1 |
| 4 | T lymphocytes as targets of statins:molecular mechanisms and therapeutic perspectives显示文摘 | Ghittoni R Lazzerini P E Pasini F L | | 0，，01： | 1 |
| 5 | JET X-ray pulse-height analysis system显示文摘 | PASINI D GILL R D HOLM J | 1988 | Rev Sci Instrum1988，59，： | 1 |
| 6 | Role of the polycomb repressive complex 2 in acute promyelocytic leukemia显示文摘 | Villa R Pasini D Gutierrez A | 2007 | Cancer Cell2007，11，6： | 1 |
| 7 | Association between extracellular water, left ventrieular mass and hypertension in haemodialysis patients 显示文摘 | Fagugll R M Pasini P Quintaliani G | 2003 | Nephrol Dial Transplant2003，18，11： | 1 |
| 8 | RET mutation profile and variable clinical manifestations in a family with multiple endocrine neoplasia type 2A and Hirschsprung's disease显示文摘 | Pasini B Rissi R Ambrosio MR | 2002 | Surgery2002，131，4： | 1 |
| 9 | T lymphocytes as targets of statins:molecular mechanisms and therapeutic perspectives显示文摘 | Ghittoni R Lazzerini PE Pasini FL | 2007 | Inflamm Allergy Drug Targets2007，6，1： | 1 |
| 10 | Genetics of epilepsy and relevance to current practice 显示文摘 | Michelucci R Pasini E Riguzzi P | 2012 | Curr Neurel Neurosci Rep2012，12，4： | 1 |
| 11 | Estimating constituent release fromFGD gypsum under different management scenarios 显示文摘 | Pasini R Walker H W | 2012 | Fuel2012，95，： | 1 |
| 12 | Blunted nocturnal blood Pressure decrease and left-ventricular mass in hypertensive hemodialysis patients显示文摘 | FAGUGLI R M QUINTALIANI G PASINI P | 2002 | Nephron2002，91，1： | 1 |
| 13 | Attention and executive functions profile in drug naive ADHD subtypes显示文摘 | Pasini A Paloscia C Alessandrelli R | 2007 | Brain Dev2007，29，7： | 1 |
| 14 | Attention and executive functions profile in drug naive ADHD subtypes显示文摘 | Pasini A Paloscia C Alessandrelli R | 2007 | Brain Dev2007，29，： | 1 |
| 15 | Air and biomonitoring of occupational exposure to anesthetic gases in the health care workers of a large hospital in Milan显示文摘 | Fustinoni A Pasini R Valla C | 2012 | G Ital Med Lav Ergon2012，34，3： | 1 |
| 16 | Acute disseminated encephalomyelitis (ADEM): report of a clinical case显示文摘 | Locatelli C Ciambra R Pasini M | 2005 | Pediatr Med Chit2005，27，12： | 1 |
| 17 | Characterization of the choline carrier of Plasmodium falciparum:a route for the selective delivery of novel antimalarial drugs显示文摘 | Biagini GA Pasini EM Hughes R | 2004 | Blood2004，104，： | 1 |
| 18 | T lymphocytes as targets of statins:molecular mechanisms and therapeutic perspectives显示文摘 | Ghittoni R Lazzerini PE Pasini FL | 2007 | Infl amm Allergy Drug Targets2007，6，1： | 1 |
| 19 | Lateral temporal lobe epilepsies:clinical and genetic features显示文摘 | Michelucci R Pasini E Nobile C | 2009 | Epilepsia2009，505，： | 1 |
| 20 | Association between extracellular water, pertension in haemodialysis Transplant, 2003, 18 ( 11 ) left ventricular mass and hypatients 显示文摘 | Fagugli R M Pasini P Quintaliani G | 2003 | Nephrol Dial2003，，： | 1 |
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