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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | A fuzzy goal pro- gramming approach to portfolio selection显示文摘 | Parra M A Terol A B Uria M V R | 2001 | European Journal of Operational Research2001，133，： | 1 |
| 3 | Strong ties,weak ties,and hu-man capital:latino immigrant employment outside the enclave显示文摘 | PFEFFER M J PARRA P A | 2009 | Rural Sociology2009，74，2： | 1 |
| 4 | The amino termi- nal sequence of VP60 from rabbit hemorrhagic disease virus supports its putative subgenomic origin显示文摘 | Parra F Boga J A Matin M S | 1993 | Vi- rus Res1993，27，3： | 1 |
| 5 | Invasive infections caused by Streptococcus pneumoniae in a tertiary-level children's hospital before the introduction of the conjugate vaccine: clinical characteris- tics and serotypes involved显示文摘 | P6rez G M Parra A Casirnir L | 2013 | Archivos Argentinos Depediatria2013，111，3： | 1 |
| 6 | Sleep-related breath ing disorders: impact on mortality of cerebrovascular disease显示文摘 | Parra O Arboix A Montserrat J M | 2004 | EurRespirJ2004，24，26： | 1 |
| 7 | Exposure to Volatile Organic Compounds(VOC) in Public Buses of Pamplona,Northern Span显示文摘 | Parra M A Elustondo D Bermejo R | 2008 | Science of The TotalEnvironment2008，，404： | 1 |
| 8 | An experimental study on pitch compensation in pedestrian-protection systems for collision avoidance and mitigation 显示文摘 | Llorca D R Sotelo M A Parra I | 2009 | IEEE Transactions on Intelligent Transportation Systems2009，10，3： | 1 |
| 9 | Diagnosis of infection in hip and knee revision surgery: intraoperative frozen section analysis显示文摘 | Frances Borrego A Martinez F M Cebrian Parra J L | 2007 | Int Orthop2007，31，1： | 1 |
| 10 | Attenuation of cerebral vasospasm after subarachnoid hem orrhage in mice overexpressing extracellular superoxide dismutase显示文摘 | Mr Girt M J Parra A Sheng H | 2002 | Stroke2002，33，9： | 1 |
| 11 | Dyeing wool at low temperatures:new method using liposomes显示文摘 | Marti M De La Maza A Parra J L | 2001 | Textile Research Journal2001，71，8： | 1 |
| 12 | Mechanical and microstructural investigation of friction spot welded AA6181-T4 aluminum alloy显示文摘 | ROSENDO T PARRA B TIER M A D | | 0，，： | 1 |
| 13 | Quantification of cytokine gene expression using an economical real-time polymerase chain reaction method based on SYBR green Ⅰ显示文摘 | PAYAN R R MEDINA M A PARRA S E | 2003 | ScandJ Immunol2003，57，5： | 1 |
| 14 | Mechanical and micro- structual investigation of friction spot welded AA6181-T4 alumin- ium alloy显示文摘 | Rosenda T Parra B Tier M A D | 2011 | Materials & Dsign2011，32，3： | 1 |
| 15 | 3D visual odometry for road vehicles显示文摘 | Garcia-Garcia R Sotelo M A Parra I | 2008 | Journal of Intelligent and Robotic Systems Archive2008，51，1： | 1 |
| 16 | Autonomous pedestrian collision avoidance using a fuzzy steering controller 显示文摘 | FERNANDEZ L D MILANES V PARRA A I GAVILAN M GARCIA D I PEREZ J SOTELO M A | 2011 | IEEE Transactions on Intelligent Transportation Systems2011，12，： | 1 |
| 17 | Towards Efficient Hydrogen Production from Glycerol by Sorption Enhanced Steam Reforming显示文摘 | He Li Parra J M S Blekkan E A | 2010 | Energy Environ Sei2010，3，8： | 1 |
| 18 | Robust visual odometry for vehicle localization in urban environments显示文摘 | Parra I Sotelo M A Llorca D F | 2010 | Robotica2010，28，3： | 1 |
| 19 | Destratification by mechanical mixers: Mixing efficiency and flow scaling显示文摘 | Hill D F Vergara A M Parra E J | 2008 | Journal of Hydraulic Engineering2008，134，12： | 1 |
| 20 | A fuzzy goal programming approach to portfolio selection显示文摘 | M Arenas Parra A Bilbao Terol M V Rodríguez Uría | 2001 | European Journal of Operational Research2001，，133： | 1 |
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