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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 3 | Exceptional preservation of soft tissue in a new specimen of Eoconfuciusornis and its biological implications显示文摘We report on an exceptional specimen of Eoconfuciusornis preserving rare soft-tissue traces of the ovary and wing. Ovarian follicles preserve a greater hierarchy than observed in Jeholornis and enantiornithines,suggesting confuciusornithiforms evolved higher rates of yolk deposition in parallel with the neornithine lineage. The preserved soft tissues of the wing indicate the presence of a propatagium and postpatagium,whereas an alular patagium is absent. Preserved remnants of the internal support network of the propatagium bear remarkable similarity to that of living birds. Soft tissue suggests the confuciusornithiform propatagium could maintain a cambered profile and generate lift. The feathers of the wing preserve remnants of their original patterning; however, this is not strongly reflected by observable differences under scanning electron microscopy(SEM). The tail plumage lacks elongate rectrices, suggesting that the earliest known confuciusornithiforms were sexually dimorphic in their plumage. | Xiaoting Zheng Jingmai K. O'Connor Xiaoli Wang Yanhong Pan Yan Wang Min Wang Zhonghe Zhou | 2017 | National Science Review2017，4，3： | 3 |
| 4 | Passivation and anodic oxidation of duplex TiN coating on stainless steel 显示文摘 | RUDENJA S PAN J WALLINDER I O | 1999 | Electrochem Soc1999，146，： | 1 |
| 5 | Random-peptide librar-ies and antigen-fragment libraries for epitope mappingand the development of vaccines and diagnostics显示文摘 | Irving M B Pan O Scott J K | 2001 | Curr Opin Chem Biol2001，5，3： | 1 |
| 6 | Deep surveying of alternative splicing com- plexity in the human transeriptome by high-throughput sequeneing 显示文摘 | Pan Q Shai O Lee LI | 2008 | Nat Genet2008，40，12： | 1 |
| 7 | The receptor for the cytotoxic ligand Trail显示文摘 | O'Rourke K O'Rourke AM | 1997 | Science1997，276，1： | 1 |
| 8 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O'Rourke K Chinnaiyan AM | 1997 | Science1997，276，： | 1 |
| 9 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O'Rourke K Chinnaiyan A M | 1997 | Science1997，276，5309： | 1 |
| 10 | Attenuation correction of PET cardiac data with low-dose average CT in PET/CT显示文摘 | Pan T Mawlawi O Luo D | 2006 | Med Phys2006，33，10： | 1 |
| 11 | A zinc finger-containing glycine-rich RNAbinding protein,atRZ-1a,has a negative impact on seed germination and seedling growth of Arabidopsis thaliana under salt or drought stress conditions 显示文摘 | KIM Y O PAN S JUNG C H | 2007 | Plant Cell Physiol2007，48，： | 1 |
| 12 | Attenuation correction of PET images with respiration-averaged CT images in PET/CT显示文摘 | Pan T Mawlawi O Nehmeh SA | 2005 | J Nucl Med2005，46，9： | 1 |
| 13 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O'Rourke K Chinnaiyan AM | 1997 | Science1997，276，： | 1 |
| 14 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O'Rourke K Chinnaiyan AM | 1997 | Science1997，276，5309： | 1 |
| 15 | Molecular cloning,character- rization and expression of goose Toll-like receptor 5 显示文摘 | FANG O PAN Z GENGS | 2012 | Mol Immuno12012，52，34： | 1 |
| 16 | Polarization and the electric field induced strain in lead lanthanum zirconate titanate ceramics显示文摘 | PAN W Y YUE C F TOSYALI O | 1992 | J Am Ceram Soc1992，75，6： | 1 |
| 17 | The receptor for the cytotoxic ligand TRAIL显示文摘 | O'Rourke K Chinnaiyan A M | 1997 | Science1997，276，5309： | 1 |
| 18 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O′Rourke K Chinnaiyan AM | 1997 | Science1997，276，： | 1 |
| 19 | Adipocyte enhancer-binding protein 1 (AEBP1)(a novel macrophage proin- flammatory mediator) overexpressian promotes and ablation at- tenuates atherosclerosis in ApoE(-/-) and LDLR (-/-) mice显示文摘 | BOGACHEV O MAJDALAWIEH A PAN X | 2011 | Mol Med2011，17，910： | 1 |
| 20 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O'Rourke K Chinnaiyan AM | 1997 | Science1997，276，5309： | 1 |
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