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| 1 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 2 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 3 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 4 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 5 | Czochralski growth of rare earth oxyorthosilicate single crystals显示文摘 | MELCHER C L MANENTE R A PETERSON C A | 1993 | J Cryst Growth1993，128，： | 2 |
| 6 | Rotational relaxation measurements of laser excited Hydrogen fluoride显示文摘 | Peterson L M Lindgulst G H Arnold C B | 1974 | J Chem Phys1974，61，8： | 2 |
| 7 | Diffusion in metals显示文摘 | PETERSON N L | 1968 | Solid State Physics1968，22，： | 2 |
| 8 | 世界家庭医生组织(WONCA)研究论文摘要汇编——高度连续的全科医疗服务可降低患者医疗费用和住院率显示文摘目的连续性服务是全科医疗的基本特征之一,其可以降低医疗成本、改善医疗公平性、提高医疗服务质量。但目前以医学专业角度,包括利用联邦医疗质量支付项目,对全科医疗服务的连续性价值进行评估的研究较为缺乏。本研究采用常用的以全科医师视角评估全科医疗服务连续性的4项指标(特定照护者连续性指数、BiceBoxerman照护连续性指标、修订连续性指标、赫芬达尔指数),评估医保参保患者接受的全科医疗服务的连续性,并分析其与医疗费用和住院率的关系。方法数据来源于经6 551例全科医师诊治的1 448 952例医保参保患者的医保报销资料。采用上述4项指标对患者接受的全科医疗服务的连续性进行评估。将接受诊疗的每例患者评价的连续性得分加权平均后,得到该例医师的连续性得分。以患者特征、全科医师特征、农村服务范围建立模型。将患者花费的可被医保A&B(住院保险和补充性医保)报销的实际医疗费用取自然对数后,采用多元线性回归分析全科医疗服务连续性与医疗费用的关系。采用Logistic回归分析全科医疗服务连续性与住院率的关系。结果对4项指标的评估结果均显示,全科医疗服务连续性与医疗费用和住院率呈高度相关,相关系数为0.86~0.99,即高度连续的全科医疗服务可以降低患者的医疗费用和住院率。在调整患者特征和全科医师特征后,将Bice-Boxerman照护连续性得分5等分,得分最高组患者较最低组患者的医疗费用降低了14.1%[($8 092比$6 958,β=-0.151,95%CI(-0.186,-0.116)],住院率降低了16.1%[OR=0.839,95%CI(0.787,0.893)]。结论高度连续的全科医疗服务可以降低医疗费用和住院率。本研究采用的4项评估指标可能与联邦医疗质量支付项目一样有效,鉴于较高的医疗资源利用率有利于降低医疗费用,该4项指标也可以用来评估医疗资源的利用情况。 | 本刊编辑部 BAZEMORE A PETTERSON S PETERSON L E | 2019 | 中国全科医学2019，22，1： | 2 |
| 9 | On the regression analysis of multivariate failure time data显示文摘 | Prentice R L Williams B J Peterson A V | 1981 | Biometrika1981，68，： | 1 |
| 10 | Identifying defects in images of rotating apples显示文摘 | Bennedsen B S Peterson D L Amy Tabb | 2005 | Computers and Electronics in Agriculture2005，48，2： | 1 |
| 11 | GENI design principles 显示文摘 | Peterson L Anderson T Blumenthal D | 2006 | IEEE Computer2006，39，9： | 1 |
| 12 | Rhinocerebral mucormycosis: evolution of the disease and treatment options显示文摘 | PETERSON K L WANG M CANALIS R F | 1997 | Laryngoscope1997，107，： | 1 |
| 13 | End-to-end congestion control avoidance on a global internet显示文摘 | L Brakrno L Peterson | 1995 | IEEE Journal on Selected Areas in Communications1995，13，8： | 1 |
| 14 | Task conflict and relationship conflict in top management teams: the pivotal role of intragroup trust 显示文摘 | SIMONS T L R S PETERSON | 2000 | Journal of Applied Psychology2000，85，1： | 1 |
| 15 | TCP Vegas: New techniques for congestion detection and avoidance显示文摘 | O'MALLEY S PETERSON L L | 1994 | Computer Communication Review1994，24，4： | 1 |
| 16 | Mapping regional forest evapotranspiration and photosynthesis by coupling satellite data with ecosystem simulation 显示文摘 | Running S W Nemani R R Peterson D L | 1989 | Eeology1989，70，： | 1 |
| 17 | Muscular fatigue and action potiential conduction velocity changes studied with frequency analysis of EMG signals 显示文摘 | Lindstrom L Magnusson S Peterson I | 1970 | Electromyography1970，10，7： | 1 |
| 18 | A novel Gastrokine,Gkn3,marks gastric atrophy and shows evidence of adaptive gene loss in humans显示文摘 | Menheniott TR Peterson AJ O'Connor L | 2010 | Gastroenterology2010，138，5： | 1 |
| 19 | Chromium supplementation for women with gestational diabetes 显示文摘 | Jovanovic L Gutierrez M Peterson CM | 1999 | J Trace Elem Exptl Med1999，12，1： | 1 |
| 20 | Oscillation criteria for nonlinear damped dynamic equation on time scales显示文摘 | Erbe L Hassan T S Peterson A | 2008 | Appl Math Comput2008，203，1： | 1 |
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