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| 1 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 2 | Aspirin dose and six-month outcome after an acute coronary syndrome显示文摘 | Martin J Quinn Herbert D Aronow Robert M Califf Deepak L Bhatt Shelly Sapp Neal S Kleiman Robert A Harrington David F Kong David E Kandzari Eric J Topol | 2004 | Journal of the American College of Cardiology2004，，6： | 1 |
| 3 | Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials显示文摘 | Viktoria L Gloy Matthias Briel Deepak L Bhatt Sangeeta R Kashyap Philip R Schauer Geltrude Mingrone Heiner C Bucher Alain J Nordmann | 2013 | BMJ . 2013 (oct2)2013，，2： | 1 |
| 4 | Aspirin plus PPI safer than clopidogrel if there is history of GI bleeding显示文摘 | Deepak L Bhatt James Scheiman David A Johnson | 2005 | N Engl J Med2005，352，3： | 1 |
| 5 | Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials显示文摘 | Viktoria L Gloy Matthias Briel Deepak L Bhatt Sangeeta R Kashyap Philip R Schauer Geltrude Mingrone Heiner C Bucher Alain J Nordmann | 2013 | BMJ (oct )2013，，221： | 1 |
| 6 | 药物洗脱支架的合理应用:权衡降低再狭窄率与晚期支架血栓形成间的关系显示文摘支架内再狭窄是一种严重的临床事件,不但可以引起复发性心绞痛和重复血运重建,还可以导致急性冠状动脉综合征。与裸金属支架(BMS)相比,药物洗脱支架(DES)显著降低了再狭窄率,其出现使介入心脏病学发生了重大变革。但由于有证据表明DES存在晚期支架内血栓形成的问题,DES的安全性成为目前关注的焦点。随机临床试验的结果并没有显示DES可导致患者在4~5年随访期后出现过多死亡。目前的建议是接受DES治疗的患者应连续服用双重抗血小板药物治疗至少12个月;而患者也必须了解这一长期治疗方案的重要性。对患者的评估应集中在出血机制异常、既往存在需要抗凝治疗的疾病、将来进行外科治疗的可能性等方面,因为上述因素都是应用DES治疗的禁忌。 | Anthony A Bavry Deepak L Bhatt 吴景涛(译) | 2009 | 世界临床医学2009，3，3： | 0 |
| 7 | Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors显示文摘Background and purpose Depression is common after stroke and is often treated with antidepressant medications(AD).ADs have also been hypothesised to improve stroke recovery,although recent randomised trials were neutral.We investigated the patterns of in-hospital AD initiation after ischaemic stroke and association with clinical and readmission outcomes.Methods All Medicare fee-for-service beneficiaries aged 65 or older hospitalised for ischaemic stroke in participating Get With The Guidelines-Stroke hospitals between April and December 2014 were eligible for this analysis.Outcome measures included days alive and not in a healthcare institution(home time),all-cause mortality and readmission within 1-year postdischarge.Propensity score(PS)-adjusted logistic regression models were used to evaluate the associations between AD use and each outcome measure.We also compared outcomes in patients prescribed selective serotonin reuptake inhibitors(SSRIs)AD versus those prescribed non-SSRI ADs.Results Of 21805 AD naive patients included in this analysis,1835(8.4%)were started on an AD at discharge.Patients started on an AD had higher rates of depression and prior ischaemic stroke,presented with higher admission National Institutes of Health Stroke Scale score and were less likely to be discharged home.Similarly,patients started on an SSRI had lower rates of discharge to home.Adjusting for stroke severity,patients started on an AD had worse all-cause mortality,all-cause readmission,major adverse cardiac events,readmission for depression and decreased home-time.However,AD use was also associated with an increased risk for the sepsis,a falsification endpoint,suggesting the presence of residual confounding.Conclusions Patients with ischaemic stroke initiated on AD therapy are at increased risk of poor clinical outcomes and readmission even after PS adjustment,suggesting that poststroke depression requiring medication is a poor prognostic sign.Further research is needed to explore the reasons why depression is associated with worse outcome,and whether AD treatment modifies this risk or not. | Mark R Etherton Shreyansh Shah Xu Haolin Ying Xian Lesley Maisch Deidre Hannah Brianna Lindholm Barbara Lytle Laine Thomas Eric E Smith Gregg C Fonarow Lee H Schwamm Deepak L Bhatt Adrian F Hernandez Emily C O'Brien | 2021 | Stroke & Vascular Neurology2021，6，3： | 0 |
| 8 | Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease显示文摘Background:The efficacy and safety of sodium-glucose cotransporter 2 inhibitors such as sotagliflozin in preventing cardiovascular events in patients with diabetes with chronic kidney disease with or without albuminuria have not been well studied. | Deepak L Bhatt | 2020 | 四川生理科学杂志2020，42，4： | 0 |
| 9 | Long-term outcomes after catheter-based renal artery denervation for resistant hypertension:final follow-up of the randomised SYMPLICITY HTN-3 Trial显示文摘Background:The SYMPLICITY HTN-3(Renal Denervation in Patients With Uncontrolled Hypertension)trial showed the safety but not efficacy of the Symplicity system(Medtronic,Santa Rosa,CA,USA)at 6 months follow-up in patients with treatment-resistant hypertension.This final report presents the 36-month follow-up results.Methods:SYMPLICITY HTN-3 was a single-blind,multicentre,sham-controlled,randomised clinical trial,done in 88 centres in the USA.Adults aged 18-80 years,with treatment-resistant hypertension on stable,maximally tolerated doses of three or more drugs including a diuretic,who had a seated office systolic blood pressure of 160 mm Hg or more and 24 h ambulatory systolic blood pressure of 135 mm Hg or more were randomly assigned(2:1)to receive renal artery denervation using the single electrode(Flex)catheter or a sham control. | Deepak L Bhatt | 2022 | 四川生理科学杂志2022，44，9： | 0 |
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