|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors显示文摘 | Martyn E. Caplin Marianne Pavel Jaros?aw B. ?wik?a Alexandria T. Phan Markus Raderer Eva Sedlá?ková Guillaume Cadiot Edward M. Wolin Jaume Capdevila Lucy Wall Guido Rindi Alison Langley Séverine Martinez Jo?lle Blumberg Philippe Ruszniewski | 2014 | The New England Journal of Medicine2014，，： | 3 |
| 3 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 4 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 5 | Recent Advances in Analysis of Chinese Medical Plants and Traditional Medicines显示文摘 | Jitka Moravcova | 2004 | Journal of Chromatography B2004，，812： | 1 |
| 6 | Modelling the spatial structure of forest stands by multivariate pointprocesses with hierarchical interactions 显示文摘 | Pavel Grabarnik Aila S rkk | 2009 | Ecological Modelling2009，220，910： | 1 |
| 7 | Treatment of acute agitation in psychotic disorders显示文摘 | PAVEL M JAN P JAROMIR S | 2005 | Neuroendocrinol Lett2005，26，4： | 1 |
| 8 | Expression of class III β-tubulin in normal and neoplastic human tissues显示文摘 | E. Dráberová Zdenek Lukás Dagmar Ivanyi Vladimír Viklicky Pavel Dráber | 1998 | Histochemistry and Cell Biology1998，，3： | 1 |
| 9 | Inhibition effect of free ammonia and free nitrous acid on nitrite-oxidising bacteria during sludge liquor treatment:influence of feeding strategy 显示文摘 | PAVEL S JAN B LUKAS P | 2014 | Chemical Papers2014，68，7： | 1 |
| 10 | Presynaptic CLC-3 deter-mines quantal size of inhibitory transmission in the hippocampus显示文摘 | Vladimir R Ludmila D Pavel S | 2011 | Nat Neurosci2011，4，： | 1 |
| 11 | Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas显示文摘 | PAVELIC K KRIZANAC S CACEV T | 2001 | Mol Med2001，7，7： | 1 |
| 12 | Controversy over the great flood hypotheses in the Black Sea in light of geological, paleontological, and archaeological evidence显示文摘 | VALENTINA Y H ALLAN S G PAVEL D | 2007 | Quaternary International2007，，7： | 1 |
| 13 | Role of aquifer storage in water reuse显示文摘 | Dillon P Pavelic P Toze S | 2006 | Desalination2006，188，13： | 1 |
| 14 | The consequences of insulin-like growth factors/receptors dysfunction in lung cancer显示文摘 | PAVELIC J KRIZANAC S KAPITANOVIC S | 2005 | Am J Respir Cell Mol Biol2005，32，1： | 1 |
| 15 | Evaporation changes over the contiguous United States and the former USSR:A reassessment显示文摘 | Valentin S Golubev Jay H Lawrimore Pavel Ya Groisman | 2006 | Geophysical Research Letters2006，28，13： | 1 |
| 16 | The consequences of insulin-like growth factors/receptors dysfunction in lung cancer显示文摘 | Pavelic J Krizanac S Kapitanovic S | 2005 | Am J Respir Cell Mol Biol2005，32，1： | 1 |
| 17 | Molecular identification of bacteria from a cocultore by Denaturing Gradient Gel Electro- phoresis of 16S Ribosomal DNA fragments as a tool for isolation in pure cultures 显示文摘 | Andreas T Pavel S Yehuda C | 1996 | Applied and Environmental Microbiolo- gy1996，62，： | 1 |
| 18 | Practical management of everolimus-related toxicities in patients with ad- vanced solid tumors显示文摘 | GRUNWALD V WEIKERT S PAVEL ME | 2013 | Onkologie2013，36，5： | 1 |
| 19 | Gastric cancer:the role of insulin-like growth factor 2 (IGF2) and its receptors (IGF-1R and M6P/IGF-2R)显示文摘 | PAVELIC K KOLAK T KAPITANOVI(C)S | 2003 | J Pathol2003，201，3： | 1 |
| 20 | Gastric cancer: the role of insulin-like growth factor 2 ( IGF 2) and its receptors ( IGF 1R and M6-P/IGF 2R) 显示文摘 | Pavelic K Kolak T Kapitanovic S | 2003 | J Pathol2003，201，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员