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| 1 | Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease显示文摘Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease(NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome(Met S), like insulin resistance(IR), glucose intolerance, hypertension and dyslipidemia. Recently, epidemiological studies have linked obesity, Met S, and NAFLD to decreased bone mineral density and osteoporosis, highlighting an intricate interplay among bone, adipose tissue, and liver. Osteoprotegerin(OPG), an important symbol of the receptor activator of nuclear factor-B ligand/receptor activator of nuclear factor kappa B/OPG system activation, typically considered for its role in bone metabolism, may also play critical roles in the initiation and perpetuation of obesityrelated comorbidities. Clinical data have indicated that OPG concentrations are associated with hypertension, left ventricular hypertrophy, vascular calcification, endothelial dysfunction, and severity of liver damage in chronic hepatitis C. Nonetheless, the relationship between circulating OPG and IR as a key feature of Met S as well as between OPG and NAFLD remains uncertain. Thus, the aims of the present review are to provide the existent knowledge on these associations and to discuss briefly the underlying mechanisms linking OPG and NAFLD. | Lucia Pacifico Gian Marco Andreoli Miriam D'Avanzo Delia De Mitri Pasquale Pierimarchi | 2018 | World Journal of Gastroenterology2018，24，19： | 11 |
| 2 | Food allergy in irritable bowel syndrome:The case of non-celiac wheat sensitivity显示文摘Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders, having a prevalence of 12%-30% in the general population. Most patientswith IBS attribute their symptoms to adverse food reactions. We review the role of diet in the pathogenesis of IBS and the importance of dietary factors in the management of these patients. The MEDLINE electronic database(1966 to Jan 2015) was searched using the following keywords: 'food', 'diet', 'food allergy', 'food hypersensitivity', 'food intolerance', 'IBS', 'epidemiology', 'pathogenesis', 'pathophysiology', 'diagnosis', 'treatment'. We found 153 eligible papers; 80 were excluded because: not written in English, exclusive biochemical and experimental research, case reports, reviews, and research otherwise not relevant to our specific interest. We selected 73 papers: 43 original papers, 26 reviews and 4 letters to the editor. These papers focused on IBS pathogenesis, the association between IBS and atopy, and between IBS and food allergy, the relationship between IBS and non-celiac wheat sensitivity, the role of diet in IBS. Pending further scientific evidence, a cautious approach is advisable but the concept of food allergy should be included as a possible cause of IBS, and a dietary approach may have a place in the routine clinical management of IBS. | Pasquale Mansueto Alberto D'Alcamo Aurelio Seidita Antonio Carroccio | 2015 | World Journal of Gastroenterology2015，21，23： | 5 |
| 3 | Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study.显示文摘 | Angelo Zullo Giuseppe Scaccianoce Vincenzo De Francesco Valentina Ruggiero Pasquale D’Ambrosio Luigi Castorini Leonilde Bonfrate Lucy Vannella Cesare Hassan Piero Portincasa | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 4 |
| 4 | Habitual salt intake and risk of gastric cancer: A meta-analysis of prospective studies显示文摘 | Lanfranco D’Elia Giovanni Rossi Renato Ippolito Francesco P. Cappuccio Pasquale Strazzullo | 2012 | Clinical Nutrition2012，，4： | 3 |
| 5 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 6 | Almond diversity and homozygosity define structure, kinship, inbreeding, and linkage disequilibrium in cultivated germplasm, and reveal genomic associations with nut and seed weight显示文摘Almond[Prunus dulcis Miller(D.A.Webb)]is the main tree nut species worldwide.Here,genotyping-by-sequencing(GBS)was applied to 149 almond cultivars from the ex situ collections of the Italian Council for Agricultural Research(CREA)and the Spanish National Research Council(CSIC),leading to the detection of 93,119 single-nucleotide polymorphisms(SNPs).The study of population structure outlined four distinct genetic groups and highlighted diversification between the Mediterranean and Californian gene pools.Data on SNP diversity and runs of homozygosity(ROHs)allowed the definition of kinship,inbreeding,and linkage disequilibrium(LD)decay in almond cultivated germplasm.Four-year phenotypic observations,gathered on 98 cultivars of the CREA collection,were used to perform a genome-wide association study(GWAS)and,for the first time in a crop species,homozygosity mapping(HM),resulting in the identification of genomic associations with nut,shell,and seed weight.Both GWAS and HM suggested that loci controlling nut and seed weight are mostly independent.Overall,this study provides insights on the almond cultivation history and delivers information of major interest for almond genetics and breeding.In a broader perspective,our results encourage the use of ROHs in crop science to estimate inbreeding,choose parental combinations minimizing the risk of inbreeding depression,and identify genomic footprints of selection for specific traits. | Stefano Pavan Chiara Delvento Rosa Mazzeo Francesca Ricciardi Pasquale Losciale Liliana Gaeta Nunzio D’Agostino Francesca Taranto Raquel Sanchez-Perez Luigi Ricciardi Concetta Lotti | 2021 | Horticulture Research2021，8，1： | 2 |
| 7 | ddRAD sequencing-based genotyping for population structure analysis in cultivated tomato provides new insights into the genomic diversity of Mediterranean‘da serbo’type long shelf-life germplasm显示文摘Double digest restriction-site associated sequencing(ddRAD-seq)is a flexible and cost-effective strategy for providing in-depth insights into the genetic architecture of germplasm collections.Using this methodology,we investigated the genomic diversity of a panel of 288 diverse tomato(Solanum lycopersicum L.)accessions enriched in‘da serbo’(called‘de penjar’in Spain)long shelf life(LSL)materials(152 accessions)mostly originating from Italy and Spain.The rest of the materials originate from different countries and include landraces for fresh consumption,elite cultivars,heirlooms,and breeding lines.Apart from their LSL trait,‘da serbo’landraces are of remarkable interest for their resilience.We identified 32,799 high-quality SNPs,which were used for model ancestry population structure and non-parametric hierarchical clustering.Six genetic subgroups were revealed,clearly separating most‘da serbo’landraces,but also the Spanish germplasm,suggesting a subdivision of the population based on type and geographical provenance.Linkage disequilibrium(LD)in the collection decayed very rapidly within<5 kb.We then investigated SNPs showing contrasted minor frequency allele(MAF)in‘da serbo’materials,resulting in the identification of high frequencies in this germplasm of several mutations in genes related to stress tolerance and fruit maturation such as CTR1 and JAR1.Finally,a mini-core collection of 58 accessions encompassing most of the diversity was selected for further exploitation of key traits.Our findings suggest the presence of a genetic footprint of the‘da serbo’germplasm selected in the Mediterranean basin.Moreover,we provide novel insights on LSL‘da serbo’germplasm as a promising source of alleles for tolerance to stresses. | Salvatore Esposito Teodoro Cardi Gabriele Campanelli Sara Sestili María JoséDíez Salvador Soler Jaime Prohens Pasquale Tripodi | 2020 | Horticulture Research2020，7，1： | 2 |
| 8 | Hydrocortisone promtes survival and proliferation of granulocyte-macrophage progenitors via monocyte/macrophages显示文摘 | Chikkappa G Wang G | 1989 | Exp Hematol1989，17，11： | 1 |
| 9 | Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity 显示文摘 | MARIA L P GABRIELE D L PASQUALE M | 2006 | Mediators Inflamm2006，，62： | 1 |
| 10 | Measurement of endo-tracheal tube cuff leak to predict postextubation stridor and need for reintubation显示文摘 | Sandhu R S Pasquale M D Mil er K | | 0，，06： | 1 |
| 11 | Treatment of painful osteoporotic or traumatic vertebral compression fractures by percutaneous vertebral augmentation procedures 显示文摘 | Pasquale D N Tiziana T Gianluca P | 2007 | Clin J Pain2007，23，5： | 1 |
| 12 | Study of labyrinthine function in children using the caloric test:our results显示文摘 | Melagrana A D'Agostino R Pasquale G | 1996 | Int J Pediatr Otorhinolaryngol1996，37，： | 1 |
| 13 | Analysis of erbium-doped waveguide amplifiers by a full-vectorial finite-element method 显示文摘 | PASQUALE F D ZOBOLI M | 1993 | IEEE J Lightwave Technol1993，11，10： | 1 |
| 14 | The study of optokinetic 'look' nystagmus in children:our experience显示文摘 | D'Agostino R Melagrana A Pasquale G | 1997 | Int J Pediatr Otorhinolaryngol1997，40，： | 1 |
| 15 | Improved electrochemical performance of a LiFePO4-based composite cathode显示文摘 | Prosini P P Zand D Pasqual I M | 2001 | Electrochimica Acta2001，46，23： | 1 |
| 16 | Intra-operative testing for parathyroid hormone; the Central Laboratory option显示文摘 | De Pasquale L Gobatti D Ravini ML | 2008 | J Endocrinol Invest2008，31，： | 1 |
| 17 | Homozygous C677T Mutation of the 5,10 Methylenetetrahydrofolate Reductase Gene and Hyperhomocysteinemia in Italian Patients With a History of Early-Onset Ischemic Stroke显示文摘 | Lucia Soriente Antonio Coppola Pasquale Madonna Anna Maria Cerbone Giovanni Di Minno Guiseppe Orefice Armando D’Angelo | 1998 | Stroke A Journal of Cerebral Circulation1998，，4： | 1 |
| 18 | Improved gain performance in Yb^3+-sensitized Er^3+-doped alumina (Al2O3) channel optical waveguide amplifiers 显示文摘 | CHRYSSOU C E PASQUALE F D PITT C W | 2001 | J of Lightwave Tech2001，19，3： | 1 |
| 19 | The effect of pair-induced energy transfer on the performance of silica waveguide amplifiers with Er^3+/Yb^3+ concentrations显示文摘 | M Federighi F D Pasquale | 1995 | IEEE Photonics Technology Letters1995，7，3： | 1 |
| 20 | Distributed optical fibre sensors based on spontaneous Brillouin scattering employing multimode Fabry-Perot lasers显示文摘 | SOTO M A BOLOGNINI G PASQUALE F D | 2009 | Electronics Letters2009，45，21： | 1 |
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