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| 1 | Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal显示文摘Chronic atrophic gastritis (CAG) is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue (non-metaplastic atrophy) or by glandular structures inappropriate for location (metaplastic atrophy).Epidemiological data suggest that CAG is associated with two different types of tumors:Intestinal-type gastric cancer (GC) and type Ⅰ gastric carcinoid (TⅠGC).The pathophysiological mechanisms which lead to the development of these gastric tumors are different.It is accepted that a multistep process initiating from Helicobacter pylori-related chronic inflammation of the gastric mucosa progresses to CAG,intestinal metaplasia,dysplasia and,finally,leads to the development of GC.The TⅠGC is a gastrin-dependent tumor and the chronic elevation of gastrin,which is associated with CAG,stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of TⅠGC.Thus,several events occur in the gastric mucosa before the development of intestinal-type GC and/or TⅠGC and these take several years.Knowledge of CAG incidence from superficial gastritis,its prevalence in different clinical settings and possible risk factors associated with the progression of this condition to gastric neoplasias are important issues.This editorial intends to provide a brief review of the main studies regarding incidence and prevalence of CAG and risk factors for the development of gastric neoplasias. | Lucy Vannella Edith Lahner Bruno Annibale | 2012 | World Journal of Gastroenterology2012，18，12： | 73 |
| 2 | Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis显示文摘AIM: To investigate the role of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,T&T-IS protocol,TWIST protocol). The target variable was the presence of thyroid disease. RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. The increase of sensitivity of the TWIST protocol was statistically signifi cant compared to T&T-IS. CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status. | Edith Lahner Marco Intraligi Massimo Buscema Marco Centanni Lucy Vannella Enzo Grossi Bruno Annibale | 2008 | World Journal of Gastroenterology2008，14，4： | 6 |
| 3 | Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study.显示文摘 | Angelo Zullo Giuseppe Scaccianoce Vincenzo De Francesco Valentina Ruggiero Pasquale D’Ambrosio Luigi Castorini Leonilde Bonfrate Lucy Vannella Cesare Hassan Piero Portincasa | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 4 |
| 4 | Systematic review: gastric cancer incidence in pernicious anaemia显示文摘 | L. Vannella E. Lahner J. Osborn B. Annibale | 2012 | Aliment Pharmacol Ther2012，，4： | 2 |
| 5 | No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia显示文摘 | Edith Lahner Andrea Sbrozzi-Vanni Lucy Vannella Vito Domenico Corleto Emilio Di Giulio Gianfranco Delle Fave Bruno Annibale | 2012 | Digestive and Liver Disease2012，，9： | 1 |
| 6 | Risk factors for progression to gastric neoplastic lesions in patients with a- trophic gastritis 显示文摘 | Vannella L Lahner E Osborn J et al | 2010 | Aliment Pharmacol Ther2010，31，9： | 1 |
| 7 | Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastric 显示文摘 | Vannella L Lahner E Osborn J | 2010 | Aliment Pharmacol Ther2010，31，18： | 1 |
| 8 | Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis显示文摘 | Vannella L Lahner E Osborn J | | 0，，09： | 1 |
| 9 | Cysteinyl1 eukotrienes are autocrine and paracrine regulators of fibrocyte func-tion显示文摘 | Vannella KM McMillan TR Charbeneau RP | 2007 | J Immunol2007，179，： | 1 |
| 10 | New concepts of IL-10-in- duced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis显示文摘 | Sun L Louie MC Vannella KM | 2011 | Am J Physiol Lung Cell Mol Physiol2011，300，3： | 1 |
| 11 | Pre-endoscopic screening for Helicobacter pylori and celiac disease in young anemic women显示文摘AIM:To evaluate the usefulness of pre-endoscopic serological screening for Helicobacter pylori(H pylori) infection and celiac disease in women aged<50 years affected by iron-defi ciency anemia(IDA).METHODS:One hundred and fi fteen women aged<50 years with IDA were tested by human recombinant tissue transglutaminase IgA antibodies(tTG) and anti-H pylori IgG antibodies.tTG and H pylori IgG antibody were assessed using an enzyme-linked immunosorbent assay(ELISA).All women were invited to undergo upper GI endoscopy.During gastroscopy,biopsies were collected from antrum(n=3),gastric body(n=3) and duodenum(n=4) in all patients,irrespective of test results.The assessment of gastritis was performed according to the Sydney system and celiac disease was classifi ed by Marsh's System.RESULTS:45.2% women were test-positive:41 patients positive for H pylori antibodies,9 patients for tTG and 2 patients for both.The gastroscopy compliance rate of test-positive women was significantly increased with respect to those test-negative(65.4% vs 42.8%;Fisher test P=0.0239).The serological results were confi rmed by gastroscopy in 100% of those with positive H pylori antibodies,in 50% of those with positive tTG and in 81.5% of testnegative patient.Sensitivity and specif icity were 84.8% and 100%,respectively for H pylori infection and,80% and 92.8% for tTG.Twenty-eight patients had positive H pylori antibodies and in all the patients,an active H pylori infection was found.In particular,in 23 out of 28(82%) patients with positive H pylori antibodies,a likely cause of IDA was found because of the active inflammation involving the gastric body.CONCLUSION:Anti-H pylori IgG antibody and tTG IgA antibody testing is able to select women with IDA to submit for gastroscopy to identify H pylori pangastritis and/or celiac disease,likely causes of IDA. | Lucy Vannella Debora Gianni Edith Lahner Antonio Amato Enzo Grossi Gianfranco Delle Fave Bruno Annibale | 2009 | World Journal of Gastroenterology2009，15，22： | 1 |
| 12 | Incomplete deletion of IL-4Ralpha by LysM (Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis 显示文摘 | Vannella KM Barron L Borthwick LA | 2014 | PLoS Pathog2014，10，10： | 1 |
| 13 | Risk factors for progression to gastric neoplastic lesions in patients with arophic gastritis 显示文摘 | Vannella L Lahner E Osborn J | 2010 | Aliment Pharmacol Ther2010，31，9： | 1 |
| 14 | Incomplete deletion of IL-4Ralpha by LysM (Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis 显示文摘 | Vannella KM Barton L Borthwick LA | 2014 | PLoS Pathog2014，10，10： | 1 |
| 15 | New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation ina CCL2/CCR2 axis 显示文摘 | Sun L Louie MC Vannella KM | 2011 | Am J Physiol Lung Cell Mol Physiol2011，300，3： | 1 |
| 16 | Concomitant, sequential, and hybrid therapy for H. pylori eradication: a pilot study.显示文摘 | Angelo Zullo Giuseppe Scaccianoce Vincenzo De Francesco Valentina Ruggiero Pasquale D’Ambrosio Luigi Castorini Leonilde Bonfrate Lucy Vannella Cesare Hassan Piero Portincasa | 2013 | Clinics and Research in Hepatology and Gastroenterology2013，，： | 1 |
| 17 | Macrophages in tissue repair, regeneration, and fibrosis 显示文摘 | WYNN T A VANNELLA K M | 2016 | Immunity2016，44，3： | 1 |
| 18 | No higher risk for coloreetal cancer in atrophic gastritis-related hypergastrinemia 显示文摘 | Lahner E Sbrozzi-Vanni A Vannella L | 2012 | Dig Liver Dis2012，44，9： | 1 |
| 19 | Viruses as co- factors for the initiation or exacebation of lung fibrosis显示文摘 | Vannella Km Moore Bb | 2008 | Fibrogenesis Tissue Repair2008，1，1： | 1 |
| 20 | Cysteinyl leukotrienes are autocrine and paracrine regu- lators of fibrocyte function显示文摘 | Vannella KM McMillan TR Charbeneau RP | 2007 | J Immunol2007，179，11： | 1 |
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