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1Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells.Li QF Ou Yang GL Li CY Hong SG 2000World Journal of Gastroenterology2000,6,5:19
2The molecular epiemiology of HIV in Asia显示文摘Weniger BG Yutaka ta kebe Ou CY 1994J AIDS1994,8,2:1
3Ge- netic diversity and drug resistance among newly diagnosed and antiretroviral treatment-naive HIV-infected individuals in western Yunnan: a hot area of viral recombination in China 显示文摘Chen M Ma Y Duan S Xing H Yao S Su Y Luo H Yang L Chen H Fu L Qu A Ou CY Jia M Lu L 2012BMC Infect Dis2012,12,:1
4Tetramethylpyrazine reduces ceUular inflammatory response following permanent focal cerebral ischemia in rats显示文摘Kao TK Chang CY Ou YC 2013Exp Neurol2013,247,:1
5A comparative study of initial use of intravenous immunoglobulin and prednisolone treatments in childhood idiopathic thrombocytopenic purpur 显示文摘Ou Cy Hsieh KS Chiou YH 2006Acta Paediatr Taiwan2006,47,5:1
6DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells显示文摘Ou CY Kwok S Mitchell SW 1988Science1988,239,4837:1
7Significant relationship between serum high-sensitivity C-reactive protein, high-density lipoprotein cholesterol levels and children with Kawasaki disease and coronary artery lesions显示文摘Ou CY Tseng YF Lee CL 2009Formos Med Assoc2009,108,9:1
8The role of Mycoplasma pneumoniae in acute exacerbation of asthma in children显示文摘Ou CY Tsenq YF Chiou YH 2008Acta Paediatr Taiwan2008,49,1:1
9Data classification with radial basis function networks based on a novel kernel density estimation algorithm显示文摘Oyang YJ Hwang SC Ou YY Chen CY Chen ZW 0,,01:1
10The role of bactericidal/ permeability-increasing protein in men with chronic obstructive pulmonary disease显示文摘Chen CZ Ou CY Wang RH 2012Copd2012,9,2:1
11First trimester diagnosis of hol oprosencephaly and cyclopia with triploidy by transvaginal three dimensional ultrasonography显示文摘Hsu TY Chang SY Ou CY 2001Eur J Obstet Gynecol Reprod Biol2001,96,2:1
12Identification of Toxigenic Clostridium dijficile by the Polymerase Chain Reaction 显示文摘Kato N Ou CY Kato H 1991J Clin Microbiol1991,1,29:1
13The molecular epidemiology of HIV in Asia 显示文摘Weniger BG Takebe Y Ou CY 1994AIDS1994,8,2:1
14Allopregnanolone in- creases the number of dopaminergic neurons in substantia nigra of triple transgenic mouse model of alzheimer's dis- ease 显示文摘Sun CY Ou X Farley JM 2012Curr Alzheimer Res2012,9,:1
15Is muta- ted MTHFR a risk factor for neural tube defects? 显示文摘Posey DL Khoury MJ Mulinare J Adams MJ Jr Ou CY 1996Lancet1996,347,9002:1
16The molecular epidemiology of HIV in Asia显示文摘Weniger BG Takebe Y Ou CY 1994AIDS1994,8,112:1
17The role of Mycoplasma pneumoniae in acute exacerbation of asthma in children显示文摘Ou CY Tseng YF Chiou YH 2008Acta Pacdiatr TaiWan2008,49,1:1
18The molecular epidemiolo- gy of HIV in Asia显示文摘Weniger BG Takebe Y Ou CY 1994AIDS1994,8,2:1
19DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells 显示文摘Ou CY Kwok S Mitchell SW 1988Science1988,239,4837:1
20Allergies and risk of head and neck cancer: an original study plus meta-analysis 显示文摘Hsiao JR Ou CY Lo HI 2013PLoS One2013,8,55:1
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