Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

查看全文 作　　者：Xiaocui [1,2]Xu;Guoqiang [1]Li;Congru [1,2]Li;Jing [1]Zhang;Qiang [3]Wang;David [4]KSimmons;Xuepeng [1,2]Chen;Naveen [4]Wijesena;Wei [1,2]Zhu;Zhanyang [5]Wang;Zhenhua [5]Wang;Bao [5]Ju;Weimin [6]Ci;Xuemei [6]Lu;Daqi [7]Yu;Qian-fei [6]Wang;Neelakanteswar [8]Aluru;Paola [9]Oliveri;Yong [7]EZhang;Mark [4]QMartindale;Jiang [1,2,10]Liu

机构地区：[1]CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;[2]U niversity of Chinese Academy of Sciences,Beijing 100029,China;[3]In s titu te of Apiculture Research,Chinese Academy of Agriculture Sciences,Beijing 100093,China;[4]Whitney Laboratory for Marine Bioscience,University of Florida,FL 32080,USA;[5]College of Life Sciences,Yantai University,Yantai 265600,China;[6]CAS Key Laboratory of Genomics and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;[7]Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;[8]Biology Department,Woods Hole Oceanographic Institution,MA 02543,USA;[9]Departments of Genetics,Evolution and Environment,and Cell and Developmental Biology,University College London,London WC1E 6BT,UK;[10]CAS Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China

出　　处：《National Science Review》索引2019年第6卷第5期,共11页

基　　金：supported by the National Key Research and Development Program of China(2018YFC1003303);the Strategic Priority Research Program of the CAS(XDB13040200);the National Natural Science Foundation of China(91519306,31425015);the Youth Innovation Promotion Association of the CAS and the Key Research Program of Frontier Sciences,CAS(QYZDY-SSW-SMC016) 摘　　要：Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. 关键词：DNA METHYLATION EVOLUTION development REPROGRAMMING

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Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

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