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| 1 | Intraductal endoscopic radiofrequency ablation for the treatment of hilar non-resectable malignant bile duct obstruction显示文摘AIM: To evaluate the safety and technical success of endoscopic radiofrequency ablation(RFA) for palliative treatment of malignant hilar bile duct obstruction. METHODS: In this study, a recently CE and FDA-approved endoscopic RFA catheter was first tested in an ex vivo pig liver model to study the effect of electrosurgical variables on the extent of the area of induced necrosis. Subsequently, a retrospective analysis was conducted of all patients treated with endoscopic RFA for malignant biliary obstruction at our center between February 2012 and April 2013. All patients received an additional plastic stent implantation into the biliary tree following RFA. RESULTS: In the pig model, ablation time of 60-90 seconds using the bipolar soft coagulation mode at 8-10 watts with an effect of 8 was found to be the most feasible setting. Twelve patients(5 females, 7 males; mean age, 70 years) underwent 19 endoscopic RFA(range, 1-5) sessions. Deployment of RFA was successful in all patients. Systemic chemotherapy was administered in four patients. We observed biliary bleeding 4-6 wk after the intervention in three cases and two of these patients died: in one patient, spontaneous hemobilia occurred, whereas bleeding started during stent extraction in the other. In the third patient, bleeding was stopped by insertion of a non-covered self-expanding metal stent. Another three patients developed cholangitis during follow-up. Seven patients died during follow-up and median survival was 6.4 mo(95%CI: 0.05-12.7) from the time of the first RFA. CONCLUSION: Endoscopic RFA is an easy to perform and technically highly successful procedure. However, hemobilia possibly associated with RFA occurred in three of our patients. Therefore, larger prospective studies are needed to further evaluate the safety and efficacy of this promising new method. | Andrea Oliver Tal Johannes Vermehren Mireen FriedrichRust Jrg Bojunga Christoph Sarrazin Stefan Zeuzem Jrg Trojan Jrg Gerhard Albert | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，1： | 18 |
| 2 | Transcutaneous perianal sonography:A sensitive method for the detection of perianal inflammatory lesions in Crohn's disease显示文摘AIM: Pelvic magnetic resonance imaging (MRI) and endoanalultrasound which are established imaging methods forperianal inflammatory lesions in patients with Crohn'sdisease require expensive specialized equipments andexpertise. We investigated the feasibility and sensitivity oftranscutaneous perianal ultrasound (PAUS) using regularultrasound probes in the imaging of perianal inflammatorylesions. The sonographic findings were correlated to pelvicMRI-scans.METHODS: We performed PAUS in 25 patients with Crohn'sdisease and clinical signs of perianal inflammatory disease.VCChin a median of 10 d (range 0-75) these patients underwentMRI of the pelvis. Regular convex and linear high resolutionprobes were used for PAUS. The sonographic findings werecorrelated to the MRI findings by blinded investigators.RESULTS: The sonographic investigations were welltolerated by all patients. Fistulae typically presented ashypoechoic tracks. Twenty-nine fistulae were detected in22 patients. Abscesses were detected in 7 patients andpresented as hypo- or anechoic formations. Twenty-six of29 fistulae and 6 of 7 abscesses could be confirmed byMRI. Kappa statistics showed an excellent agreement(kappa>0.83) between the two imaging methods.CONCLUSION: PAUS is a simple, painless, feasible, real-time method that can be performed without specific patientpreparation which is comparable in its sensitivity to pelvicMRI in the detection of perianal fistulae and/or abscesses.PAUS can especially be recommended as a screening toolin acute perianal disorders such as perianal abscess andfor follow-up studies of perianal inflammatory disease. | Jochen Wedemeyer Timm Kirchhoff Gernot Sellge Oliver Bachmann Joachim Lotz Michael Galanski Michael P.Manns Michael J.Gebel Jrg S.Bleck | 2004 | World Journal of Gastroenterology2004，10，19： | 8 |
| 3 | SEMS vs cSEMS in duodenal and small bowel obstruction:High risk of migration in the covered stent group显示文摘AIM:To compare clinical success and complications of uncovered self-expanding metal stents(SEMS)vs covered SEMS(cSEMS)in obstruction of the small bowel.METHODS:Technical success,complications and outcome of endoscopic SEMS or cSEMS placement in tumor related obstruction of the duodenum or jejunum were retrospectively assessed.The primary end points were rates of stent migration and overgrowth.Secondary end points were the effect of concomitant biliary drainage on migration rate and overall survival.The data was analyzed according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines.RESULTS:Thirty-two SEMS were implanted in 20 patients.In all patients,endoscopic stent implantation was successful.Stent migration was observed in 9 of16 cSEMS(56%)in comparison to 0/16 SEMS(0%)implantations(P=0.002).Stent overgrowth did not significantly differ between the two stent types(SEMS:3/16,19%;cSEMS:2/16,13%).One cSEMS dislodged and had to be recovered from the jejunum by way of laparotomy.Time until migration between SEMS and cSEMS in patients with and without concomitant biliary stents did not significantly differ(HR=1.530,95%CI0.731-6.306;P=0.556).The mean follow-up was 57±71 d(range:1-275 d).CONCLUSION:SEMS and cSEMS placement is safe in small bowel tumor obstruction.However,cSEMS is accompanied with a high rate of migration in comparison to uncovered SEMS. | Oliver Waidmann Jrg Trojan Mireen Friedrich-Rust Christoph Sarrazin Wolf Otto Bechstein Frank Ulrich Stefan Zeuzem Jrg Gerhard Albert | 2013 | World Journal of Gastroenterology2013，19，37： | 4 |
| 4 | Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection显示文摘A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up. | Thorsten Brechmann Justyna Swol Veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 5 | Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network显示文摘 | Oliver Batistic J?rg Kudla | 2004 | Planta2004，，6： | 2 |
| 6 | Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma显示文摘 | Verena K?berle Bernd Kronenberger Thomas Pleli J?rg Trojan Esther Imelmann Jan Peveling-Oberhag Martin-Walter Welker Mohammed Elhendawy Stefan Zeuzem Albrecht Piiper Oliver Waidmann | 2013 | European Journal of Cancer2013，，： | 2 |
| 7 | Rabbit Hemorrhagic Disease Virus: Genome Organization and Polyprotein Processing of a Calicivirus Studied after Transient Expression of cDNA Constructs显示文摘 | Gregor Meyers Christoph Wirblich Heinz-Jürgen Thiel J?rg Oliver Thumfart | 2000 | Virology2000，，2： | 1 |
| 8 | Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network显示文摘 | Oliver Batistic J?rg Kudla | 2004 | Planta2004，，6： | 1 |
| 9 | Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control显示文摘 | Hans Scheffel Hatem Alkadhi André Plass Robert Vachenauer Lotus Desbiolles Oliver Gaemperli Tiziano Schepis Thomas Frauenfelder Thomas Schertler Lars Husmann Jürg Grunenfelder Michele Genoni Philipp A. Kaufmann Borut Marincek Sebastian Leschka | 2006 | European Radiology2006，，12： | 1 |
| 10 | Predictive impact of MGMT promoter methylation in glioblastoma of the elderly显示文摘 | Guido Reifenberger Bettina Hentschel J?rg Felsberg Gabriele Schackert Matthias Simon Oliver Schnell Manfred Westphal Wolfgang Wick Torsten Pietsch Markus Loeffler Michael Weller | 2012 | Int J Cancer2012，，6： | 1 |
| 11 | Integration and channeling of calcium signaling through the CBL calcium sensor/CIPK protein kinase network显示文摘 | Oliver Batistic J?rg Kudla | 2004 | Planta2004，，6： | 1 |
| 12 | Neuropeptide and kinin antagonists显示文摘 | Hill RG Oliver KR | 2007 | Handb Exp Pharmacol2007，，177： | 1 |
| 13 | DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: Role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1显示文摘 | Romain Pacaud Quentin Sery Lisa Oliver Fran?ois M. Vallette J?rg Tost Pierre-Fran?ois Cartron | 2014 | Biochimie2014，，： | 1 |
| 14 | Morphology of the maxillary lateral incisor in cases of unilateral impaction of the maxillary canine 显示文摘 | Oliver RG Mannion JE Robinson JM | 1989 | Br J Orthod1989，16，： | 1 |
| 15 | Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control显示文摘 | Hans Scheffel Hatem Alkadhi André Plass Robert Vachenauer Lotus Desbiolles Oliver Gaemperli Tiziano Schepis Thomas Frauenfelder Thomas Schertler Lars Husmann Jürg Grunenfelder Michele Genoni Philipp A. Kaufmann Borut Marincek Sebastian Leschka | 2006 | European Radiology2006，，12： | 1 |
| 16 | Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control显示文摘 | Hans Scheffel Hatem Alkadhi André Plass Robert Vachenauer Lotus Desbiolles Oliver Gaemperli Tiziano Schepis Thomas Frauenfelder Thomas Schertler Lars Husmann Jürg Grunenfelder Michele Genoni Philipp A. Kaufmann Borut Marincek Sebastian Leschka | 2006 | European Radiology2006，，12： | 1 |
| 17 | Morphology of tile maxillary lateral incisor in cases of unilateral impaction of the maxilla17 canine 显示文摘 | Oliver RG Mannion JE Robinson JM | 1989 | Br J Orthod1989，16，： | 1 |
| 18 | Different techniques of residual composite removal following debonding显示文摘 | Oliver RG Griffiths J | 1992 | Br J Orthod1992，19，2： | 1 |
| 19 | Morphology of the maxillary lateral incisor in cases of unilateral impaction of the maxillary canine 显示文摘 | Oliver RG Mannion JE Robinson JM | 1989 | Br J Orthod1989，16，： | 1 |
| 20 | Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism显示文摘 | Nicola Oehler Tassilo Volz Oliver D. Bhadra Janine Kah Lena Allweiss Katja Giersch Jeanette Bierwolf Kristoffer Riecken J?rg M. Pollok Ansgar W. Lohse Boris Fehse Joerg Petersen Stephan Urban Marc Lütgehetmann Joerg Heeren Maura Dandri | 2014 | Hepatology2014，，5： | 1 |
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