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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids显示文摘 | M. Alvarez-Lopez María Dolores Pereda J.A. del Valle M. Fernandez-Lorenzo M.C. Garcia-Alonso O.A. Ruano M.L. Escudero | 2009 | Acta Biomaterialia2009，，5： | 3 |
| 3 | Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids显示文摘 | M. Alvarez-Lopez María Dolores Pereda J.A. del Valle M. Fernandez-Lorenzo M.C. Garcia-Alonso O.A. Ruano M.L. Escudero | 2009 | Acta Biomaterialia2009，，5： | 2 |
| 4 | Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents显示文摘The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert atmosphere.The effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron microscopy.Compared with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass content.Complete metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave bagasse.These results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing agent.Therefore,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking. | Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 5 | Sevoflurane in airway management using fibrobronchoscopy:apropos of 2 difficult orotracheal intubation cases显示文摘 | FERRA M VILA P ESCUDERO A | 1999 | Rev Esp Anestesiol Reanim1999，46，6： | 1 |
| 6 | Gas chromatography-olfactometry and chemical quantitative study of the aroma of six premium quality Spanish aged red wines 显示文摘 | Cullere L Escudero A Cacho J | 2004 | Journal of Agricultural and Food Chemistry2004，52，6： | 1 |
| 7 | Equivalent wall method for dynamic characterisation of thermal bridges显示文摘 | Martin K Escudero C Erkoreka A | 2012 | Energy and Buildings2012，55，： | 1 |
| 8 | Molecular characterization of microbial populations in a low-grade copper ore bioleaching test heap 显示文摘 | Demergasso C S Galleguillos P P A Escudero G L V | 2005 | Hydrometallurgy2005，80，4： | 1 |
| 9 | Chemical characterization of the aroma of grenache rose wines:aroma extract dilution analysis,quantitative determination,and sensory reconstitution studies显示文摘 | FERREIRA V ORTIAN N ESCUDERO A | 2002 | J Agrie Food Chem2002，50，： | 1 |
| 10 | Regenerative role of seed banks following an intense soil disturbance显示文摘 | LUZURIAGA A L ESCUDERO A OLANO J M | 2005 | Acta Oecologica2005，27，1： | 1 |
| 11 | X-ray microtomographyic study of nanoclay-polypropylene foams显示文摘 | Ma Y Pyrz R Rodriguez-Perez M A Escudero J Rauhe J Ch Su X | 2011 | Cellular Polymers2011，30，3： | 1 |
| 12 | The Aroma of Grenache Red Wine Hierarchy and Nature of Its Main Odorants 显示文摘 | FERREIRA V LOPEZ R ESCUDERO A | 1998 | Sci Food Agric1998，77，： | 1 |
| 13 | XEI,OX (capecitabine plus oxaliplatin) as first - line treatment for elderly patients over 70 years of age with ad- vanced colorectal cancer 显示文摘 | Feliu J Salud A Escudero P | 2006 | Br J Cancer2006，94，7： | 1 |
| 14 | Stomatal and mesophyll limitations to photosynthesis in one evergreen and one deciduous Mediterranean oak species显示文摘 | Mediavilla S Santiago H Escudero A | 2002 | Photosynthetica2002，40，： | 1 |
| 15 | Multidrug-Resistant Tuberculosis without HIV Infection: Success with Individualised Therapy显示文摘 | Escudero E Pena JM Alvarez-Sala R Vdzquez J J Ortega A | 2006 | Int J Tuberc Lung Dis2006，10，4： | 1 |
| 16 | Pharmacokinetics and tissue tolerance of azithromycin after intramuscular adminis-tration to rabbits显示文摘 | Escudero E Fernandez-Varon E Marin P Espuny A | 2006 | Research in Veterinary Science2006，，81： | 1 |
| 17 | Circulating miRNAs as potential biomarkers of therapy effectiveness in rheu- matoid arthritis patients treated with anti-TNFα显示文摘 | Castrc-Villegas C Perez-Sanchez C Escudero A | 2015 | Arthritis Res Ther2015，17，1： | 1 |
| 18 | Investigation on the role played by fermentation esters in the aroma of young Spanish wines by multivariate analysis显示文摘 | Ferreira V Peoa C Escudero A | 1995 | J Sci Food Agric1995，67，： | 1 |
| 19 | Prediction of the wine sensory properties related to grape variety fi'om dynamic- headspace gas chromatography-olfactometry data显示文摘 | Campo E Ferreira V Escudero A | 2005 | Agric Food Chem2005，53，14： | 1 |
| 20 | Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids 显示文摘 | ALVAREZ-LOPEZ M PEREDA M D DEL VALLE J A FERNANDEZ-LORENZO M GARCIA-ALONSO M C RUANO OA ESCUDERO M L | 2010 | Acta Biomaterialia2010，6，： | 1 |
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