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| 1 | Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liver resection显示文摘AIM:To characterize the impact of the Pringle ma-neuver (PM) and ischemic preconditioning (IP) on total blood supply to the liver following hepatectomies. METHODS: Sixty one consecutive patients who un-derwent hepatic resection under in flow occlusion were randomized either to receive PM alone (n = 31) or IP (10 min of ischemia followed by 10 min of reperfusion) prior to PM (n = 30). Quantification of liver perfusion was measured by Doppler probes at the hepatic artery and portal vein at various time points after reperfusion of remnant livers. RESULTS: Occlusion times of 33 ± 12 min (mean ± SD) and 34 ± 14 min and the extent of resected liver tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liver remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in the arterial blood flow. In contrast, following IP + PM the portal vein flow remained unchanged during reperfusion and a significantly increased arterial blood flow (+56% vs baseline) was observed. In accordance with a better postischemic blood supply of the liver, hepatocellular injury, as measured by alanine aminotransferase (ALT) levels on day 1 was considerably lower in group B compared to group A (247 ± 210 U/I vs 550 ± 650 U/I, P < 0.05). Additionally, ALT levels were significantly correlated to the hepatic artery in flow.CONCLUSION: IP prevents postischemic flow reduction of the portal vein and simultaneously increases arterial perfusion, suggesting that improved hepatic macrocirculation is a protective mechanism following hepatectomy. | Oleg Heizmann Georgios Meimarakis Andreas Volk Daniel Matz Daniel Oertli Rolf J Schauer | 2010 | World Journal of Gastroenterology2010，16，15： | 12 |
| 2 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 3 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 4 | Annular pancreas associated with duodenal carcinoma显示文摘Annular pancreas (AP) is a rare congenital anomaly. Coexisting malignancy has been reported only in a few cases. We report what is, to the best of our knowledge, the first case in the English literature of duodenal adenocarcinoma in a patient with AP. In a 55-year old woman with duodenal outlet stenosis magnetic resonance cholangiopancreatography showed an aberrant pancreatic duct encircling the duodenum. Duodenojejunostomy was performed. Eight weeks later she presented with painless jaundice. Duodenopancreatectomy revealed a duodenal adenocarcinoma, surrounded by an incomplete AP. Thus, co-existent malignancy with AP can be present without obstructive jaundice and without being visible through preoperative diagnostics. | Enrico Bronnimann Silke Potthast Tatjana Vlajnic Daniel Oertli Oleg Heizmann | 2010 | World Journal of Gastroenterology2010，16，25： | 3 |
| 5 | Long-term outcomes of breast cancer patients after endoscopic axillary lymph node dissection: a prospective analysis of 52 patients显示文摘 | I. Langer T. Kocher U. Guller J. Torhorst D. Oertli F. Harder M. Zuber | 2005 | Breast Cancer Research and Treatment2005，，1： | 2 |
| 6 | 显示文摘 | Atef F Oertli A G | 1997 | J Am Chem Soc1997，119，： | 1 |
| 7 | Controlled release of fertilizer minerals by encapsulating membranes IIEfficiency of recovery, influence of soil moisture, mode of application and other consideration related to use显示文摘 | Lunt O R Oertli J J | 1962 | Soil Science Society Proceeding1962，26，6： | 1 |
| 8 | Up-regulation of tubular epithelial interleukin-12 in autoimmune MRL-Fas Lpr mice renal injury显示文摘 | Fan X Oertli B Wuthrieh RP | 1997 | Kidney Int1997，51，1： | 1 |
| 9 | Finite element modelingof ball screw feed drive systems 显示文摘 | Zaeh MF Oertli T Milberg J | 2007 | Ann CIRP online 30 June2007，，53： | 1 |
| 10 | Finite element modelling of ball screw feed drive systems 显示文摘 | Zaeh M F Oertli T Milberg J | 2004 | CIRP Annals- Manufacturing Technology2004，53，1： | 1 |
| 11 | Helicobacter pylori γ-glutamyltranspeptidase and vacuolatingcytotoxin promote gastric persistence and immune tolerance显示文摘 | Oertli M Noben M Engler DB | 2013 | Proc Natl Acad Sci U S A2013，110，8： | 1 |
| 12 | Effect of salinity on susceptibility of sunflower plants to smog显示文摘 | Oertli J J | 1959 | Soil Science1959，87，： | 1 |
| 13 | Gastric necrosis complicating lately a Nissen fundoplication显示文摘 | Nicola Patuto Yves Acklin Daniel Oertli Igor Langer | 2008 | Langenbeck’s Archives of Surgery2008，，1： | 1 |
| 14 | Effect of host plant nitrogen fertilization on the biology of the two-spotted spider mite,Tetranychus urticae显示文摘 | Wermelinger B Oertli J J Delucchi V | | 0，，： | 1 |
| 15 | Primary carcinoma of the gallbladder: operative experience during a 16 year period显示文摘 | Tondeli P | 1993 | Eur J Surg1993，159，： | 1 |
| 16 | Juxtapapillary duode-nal diverticula:MDCT findings in 1010 patients and proposal fora new classification显示文摘 | WiesnerW BeglingerCH Oertli D | 2009 | JBR-BTR2009，92，4： | 1 |
| 17 | Finite element mod- eling of ball screw feed drive systems 显示文摘 | ZEAH M F OERTLI T MILBERG J | 2004 | CIRP Annals- Manufacturing Technology2004，53，1： | 1 |
| 18 | Finite Element Modelling of Ball Screw Feed Drive Systems显示文摘 | Zaeh M F Oertli T | 2004 | CIRP Annals-Manu- faeturing Technology2004，53，： | 1 |
| 19 | Controlled-release fertilizers显示文摘 | Oertli J J | 1980 | Nutrient Cycling in Agroecosystems1980，1，2： | 1 |
| 20 | The mobility of boron in plants 显示文摘 | Oertli J J | 1993 | Plant and Soil1993，，： | 1 |
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