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| 1 | Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liver resection显示文摘AIM:To characterize the impact of the Pringle ma-neuver (PM) and ischemic preconditioning (IP) on total blood supply to the liver following hepatectomies. METHODS: Sixty one consecutive patients who un-derwent hepatic resection under in flow occlusion were randomized either to receive PM alone (n = 31) or IP (10 min of ischemia followed by 10 min of reperfusion) prior to PM (n = 30). Quantification of liver perfusion was measured by Doppler probes at the hepatic artery and portal vein at various time points after reperfusion of remnant livers. RESULTS: Occlusion times of 33 ± 12 min (mean ± SD) and 34 ± 14 min and the extent of resected liver tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liver remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in the arterial blood flow. In contrast, following IP + PM the portal vein flow remained unchanged during reperfusion and a significantly increased arterial blood flow (+56% vs baseline) was observed. In accordance with a better postischemic blood supply of the liver, hepatocellular injury, as measured by alanine aminotransferase (ALT) levels on day 1 was considerably lower in group B compared to group A (247 ± 210 U/I vs 550 ± 650 U/I, P < 0.05). Additionally, ALT levels were significantly correlated to the hepatic artery in flow.CONCLUSION: IP prevents postischemic flow reduction of the portal vein and simultaneously increases arterial perfusion, suggesting that improved hepatic macrocirculation is a protective mechanism following hepatectomy. | Oleg Heizmann Georgios Meimarakis Andreas Volk Daniel Matz Daniel Oertli Rolf J Schauer | 2010 | World Journal of Gastroenterology2010，16，15： | 12 |
| 2 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 3 | Annular pancreas associated with duodenal carcinoma显示文摘Annular pancreas (AP) is a rare congenital anomaly. Coexisting malignancy has been reported only in a few cases. We report what is, to the best of our knowledge, the first case in the English literature of duodenal adenocarcinoma in a patient with AP. In a 55-year old woman with duodenal outlet stenosis magnetic resonance cholangiopancreatography showed an aberrant pancreatic duct encircling the duodenum. Duodenojejunostomy was performed. Eight weeks later she presented with painless jaundice. Duodenopancreatectomy revealed a duodenal adenocarcinoma, surrounded by an incomplete AP. Thus, co-existent malignancy with AP can be present without obstructive jaundice and without being visible through preoperative diagnostics. | Enrico Bronnimann Silke Potthast Tatjana Vlajnic Daniel Oertli Oleg Heizmann | 2010 | World Journal of Gastroenterology2010，16，25： | 3 |
| 4 | Gastric necrosis complicating lately a Nissen fundoplication显示文摘 | Nicola Patuto Yves Acklin Daniel Oertli Igor Langer | 2008 | Langenbeck’s Archives of Surgery2008，，1： | 1 |
| 5 | Early versus delayed cholecystectomy in patients with biliary acute pancreatitis显示文摘 | Christian A. Nebiker Daniel M. Frey Christian T. Hamel Daniel Oertli Christoph Kettelhack | 2009 | Surgery2009，，3： | 1 |
| 6 | Simplified placement and management of cutting setons in the treatment of transsphincteric anal fistula: technical note显示文摘 | Christian T. Hamel Walter R. Marti Daniel Oertli | 2004 | International Journal of Colorectal Disease2004，，4： | 1 |
| 7 | surgery of the thyroid and parathyroid glands 显示文摘 | Daniel Oertli Robert Udelsman | 2007 | springer2007，，： | 1 |
| 8 | Major Vascular Resection and Prosthetic Replacement for Retroperitoneal Tumors显示文摘 | Philipp Fueglistaler MD Lorenz Gurke MD Peter Stierli MD Tamim Obeid MD Christoph Koella MD Daniel Oertli MD Christoph Kettelhack MD | 2006 | World Journal of Surgery2006，，7： | 1 |
| 9 | Mammotome: Less Invasive than ABBI with Similar Accuracy for Early Breast Cancer Detection显示文摘 | Walter P. Weber Rosanna Zanetti Igor Langer Sophie Dellas Markus Zuber Holger Moch Eugenia Remmel Daniel Oertli Edward Wight Walter R. Marti | 2005 | World Journal of Surgery2005，，： | 1 |
| 10 | Mammotome: Less Invasive than ABBI with Similar Accuracy for Early Breast Cancer Detection显示文摘 | Walter P. Weber M.D. Rosanna Zanetti M.D. Igor Langer M.D. Sophie Dellas M.D. Markus Zuber M.D. Holger Moch M.D. Eugenia Remmel M.D. Daniel Oertli M.D. Edward Wight M.D. Walter R. Marti M.D | 2005 | World Journal of Surgery2005，，4： | 1 |
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