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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Systematic review and classifieation of complications after anterior, posterior, apieal, and total vaginal mesh implantation for prolapse repair显示文摘 | Barski D Otto T Gerullis H | 2014 | Surg Teehnol Int2014，24，： | 1 |
| 3 | Function of Nic- otiana tabacum aquaporins as chloroplast gas pores challenges the concept of membrane COz permeability 显示文摘 | Uehlein N Otto B Hanson D T | 2008 | The Plant Cell Online2008，20，3： | 1 |
| 4 | Prognosis and differential diagnosis of Purtscher's retinopathy显示文摘 | Schmidt D Otto T | 2004 | Ophthalmologe2004，101，6： | 1 |
| 5 | Detection of simulated interstitial lung disease and catheters with selenium, storage phosphor, and film-baseradiography 显示文摘 | Bernhardt T M Otto D Reichel G | 1999 | Radiology1999，213，2： | 1 |
| 6 | Ammonia,volatile fatty acids,phenolics and odour offensiveness in manure from growing pigs fed diets reduced in protein concentration显示文摘 | Otto M Yokoyama R D Bermuth T V | 2003 | Journal of Animal Science2003，81，： | 1 |
| 7 | Phase Ⅰ and Ⅱ enzymes and antioxidant responses in different tissues of brown bullheads from relatively polluted and non-polluted systems显示文摘 | OTTO D M MOON T W | 1996 | Arch Environ Contam Toxicol1996，31，1： | 1 |
| 8 | Kinematic and contact stress analysis of posterior malleolus fractures of the ankle 显示文摘 | Fitzpatrick D C Otto J K Mckinlry T O | 2011 | J Orthop Trauma2011，18，5： | 1 |
| 9 | Prognosis and differential diagnosis of Purtscher's retinopathy 显示文摘 | Schmidt D Otto T | 2004 | Ophthalmologe2004，101，6： | 1 |
| 10 | Commitment of C3HIOT1-2 pluripotent stem cells to the adipocyte lineage 显示文摘 | Tang Q Q Otto T C Lane M D | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 11 | Kinematic and contact stress analysis of posterior malleolus fractures of the ankle显示文摘 | FITZPATRICK D C OTTO J K MCKINLEY T O | 2004 | J Orthop Trauma2004，18，： | 1 |
| 12 | BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13 显示文摘 | Otto T C Bowers R R Lane M D | 2007 | Biochem Biophys Res Commun2007，353，4： | 1 |
| 13 | Function of Nicotiana tabacum aquaporins as chloroplast gas pores challenges the concept of membrane CO2 penmeability 显示文摘 | Uehlein N Otto B Hanson D T | 2008 | Plant Cell2008，20，： | 1 |
| 14 | Molecular differentiation of sexchromosomes probed by comparative genomichybridization显示文摘 | TRAUT W SAHARA K OTTO T D | 1999 | Chromo-soma1999，108，： | 1 |
| 15 | Kinematic and contact stress analysis of posterior malleolus fractures of the ankle显示文摘 | Fitzpatrick D C Otto J K Mc Kinley T O | 2004 | J Orthop Trauma2004，18，5： | 1 |
| 16 | Valuation of water quality in livestock regions: an application to rural watersheds in lowa 显示文摘 | Hurley T M Otto D Holtkamp J | 1999 | Journal of Agriculture and Applied Economics1999，31，1： | 1 |
| 17 | Use of Ecotilling as an efficient SNP discovery tool to survey genetic variation in wild populations of Populus trichocarpa显示文摘 | Gilchrist E J Haughn G W Ying C C Otto A P Zhuang J Chenung D Hamberger B Aboutorabi F Kalynyak T Johnson L Bohlmann J Ellis B E Douglas C J Cronk Q C | 2006 | Molecular Ecology2006，15，： | 1 |
| 18 | ABACAS: algorithm- based automatic eonfiguation of assembled sequenees显示文摘 | Assefa S Keane T M Otto T D | 2009 | Bioin- tormatics2009，25，15： | 1 |
| 19 | Prognosis and differential diagnosis of Purtscher's retinopathy显示文摘 | Schmidt D Otto T | 2004 | Ophthalmologe2004，101，6： | 1 |
| 20 | Mitotic clonal expansion: a synchronous process required for adi- pogenesis显示文摘 | TANG QI-QUN OTtO T C LANE M D | 2003 | Proc Natl Acad Sci USA2003，100，1： | 1 |
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