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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Rescue of Newcastle disease virus from cloned cDNA:evidence that cleavability of the fusion protein is a major determinant for virulence显示文摘 | Peeters B P De Leeuw OS Koch G | 1999 | J Virol1999，73，6： | 1 |
| 3 | A new paradigm in large scale assembly-research priori- ties in measurement assisted assembly显示文摘 | MAROPOUI OS P G MUELANER J E SUMMERS M D | 2014 | International Jour- nal of Advanced Manufacturing Technology2014，70，14： | 1 |
| 4 | Liver stiffness predicts clinical outcome in human immunodeficiency virus/hepatitis C virus‐coinfected patients with compensated liver cirrhosis显示文摘 | Nicolás Merchante Antonio Rivero‐Juárez Francisco Téllez Dolores Merino Maria José Ríos‐Villegas Manuel Márquez‐Solero Mohamed Omar Juan Macías ángela Camacho Montserrat Pérez‐Pérez Jesús Gómez‐Mateos Antonio Rivero Juan Antonio Pineda | 2012 | Hepatology2012，，1： | 1 |
| 5 | Application of hollow fibre liquid phase microextraction for the multiresidue determination of pesticides in alcoholic beverages by ultra-high pressure liquid chromatography coupled to tandem mass spectromet显示文摘 | Bola(n)os P P Romero-González R Frenich A G | | 0，，1： | 1 |
| 6 | The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease 显示文摘 | SIAN OS G MOREL M A KAPPETEIN A P | 2005 | EuroIntervention2005，1，2： | 1 |
| 7 | Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viralstrural protin VP1显示文摘 | WIGDOROVITZ A CARRILLO C DUS SANTOS M J TRONO K PERALTA A GMEZ M C ROS R D FRANZONE P M SADIR A M ESCRIBANO J M BORCA M V | 1999 | Virology1999，255，2： | 1 |
| 8 | A new recirculating enzymatic membrane reactor for ester synthesis in ionic liquid/supercritical carbon dioxide biphasic systems显示文摘 | Hernndez F J de los Ríos A P Gmez D | 2006 | Appl Catal B:Environ2006，67，122： | 1 |
| 9 | Signal amplification on planar and gel -type sensor surfaces in surface plas- mon resonance- based detection of prostate- specific antigen 显示文摘 | for competitive and direct determination of atrazine BESSELINK G A J KOOYMAN R P H VAN OS P J H J | 2004 | Analytical Biochemistry2004，333，1： | 1 |
| 10 | Employee silence:quiescence and acquiescence as responses to perceived injustice显示文摘 | Pinder G G Harl os H P | 2001 | Research in Personnel and Human Resource Management2001，20，： | 1 |
| 11 | Degradation of chlorophenols by means of advanced oxidation processes:a general review显示文摘 | Marc P T Verónica G M Ba(n)os M A | 2004 | Appl Catal B:Environmental2004，47，： | 1 |
| 12 | Polycyclic aromatic hydrocarbons in food and beverages:Analytical methods and trends显示文摘 | Plaza-Bolaos P Frenich A G Vidal J L | 2010 | Journal of Chromatography A2010，1217，41： | 1 |
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