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85篇 您的检索式:作者名="OLLERO P"
    题名 作者 年代 出处 被引量
1N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea 2008World Journal of Gastroenterology2008,14,18:2
2Diffusional Effects in TGA Gasification Experiments for Kinetic Determination显示文摘Ollero P Serrera A Arjona R 2002Fuel2002,81,:1
3The CO2Gasication Kinetics of Olive Residue 显示文摘Ollero P Serrera A Arjona R 2003Biomass & Bioenergy2003,24,:1
4Diffusional effects in TGA gasification experiments for kinetic determination 显示文摘Ollero P Serrera A Ariona R 2002Fuel2002,81,15:1
5Diffusional effects in TGA gasification experiments for kinetic determination显示文摘Ollero P Serrera A Arjona R 2002Fuel2002,81,15:1
6Pilot-plant technical assessment of wet flue gas desulfurization using limestone 显示文摘ORTIZ F 3 G VIDAL F OLLERO P 2006Industrial & Engineering Chemistry Research2006,45,:1
7The CO2 Gasification Kinetics of Olive Residue显示文摘Ollero P Serrera A Arjona R 2003Biomass and Bioenergy2003,24,2:1
8Improvement of ram sperm cryopreservation protocols assessed by sperm quality parameters and heterogeneity analysis 显示文摘Ollero M Perez P R Blanco M T 1998Cryobiology1998,37,1:1
9Pilot-plant technical assessment of wet flue gas desulfurization using limestone 显示文摘Gutierrez Ortiz F J Vidal F Ollero P 2006Ind Eng Chem Res2006,45,4:1
10Diffusional effects in TGA gasification experiments for kinetic determination显示文摘Ollero P Serrera A Arjona R 2002Fuel2002,81,15:1
116asification of Char from Dried Sewage Sludge in Fluidized Bed:Reaction Rate in Mixtures of C02 and H20 显示文摘Nilsson S 66mez-Barea A Ollero P 2013Fuel2013,105,:1
12Flue-gas desulfurization in a circulating fluidized beds:An empirical model from an experimental pilot-plant study显示文摘 Gutierrez Ortiz F J Cabanillas A 2001Industrial & Engineering Chemistry Research2001,40,23:1
13The CO2 gasification kinetics of olive residue显示文摘Ollero P Serrera A Ariona R 2003Biomass and Bioenergy2003,24,2:1
14Increased DNA damage in sperm from leukocytospermic semen samples as determined by the sperm chromatin structure assay显示文摘Juan G Alvarez Rakesh K Sharma Mario Ollero Ramadan A Saleh Mari C Lopez Anthony J Thomas Donald P Evenson Ashok Agarwal 2002Fertility and Sterility2002,,2:1
15An experimental study of flue gas desulfurization in pilot spray dryer显示文摘OLLERO P SALVADOR L CANADAS L 1997Environmental Progress1997,16,1:1
16Pilot-plant Tech nieal Assessment of Wet Flue Gas Desulfurization U sing Limestone显示文摘Gutierrez Ortiz F J Vidal F Ollero P 2006Industrial and Engineering Chemis try Research2006,45,4:1
17Air-steam gasification of biomass in a fluidised bed: Process optimisation by enriched air 显示文摘Campoy M G6mez-Barea A Vidal F B Ollero P 2009Fuel Processing Technology2009,90,5:1
18An approximate method for solving gas-solid non-catalytic reactions显示文摘Gomez-Barea A Ollero P 2006Chemical Engineering Science2006,61,11:1
19An approximate method for solving gas-solid non-catalytic reactions显示文摘 mez-Barea A Ollero P 2006Chemical Engineering Science2006,61,11:1
20A kinetic study of the oxidation of S(Ⅳ) in seawater显示文摘Vidal B F Ollero P 2003 2003Environ Sci Technol2003,35,:1
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