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153篇 您的检索式:作者名="OLIVIERI D"
    题名 作者 年代 出处 被引量
1Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions显示文摘Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials.Guido Giordano Massimo Pancione Nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario Rosario D’Andrea 2017World Journal of Gastroenterology2017,23,32:7
2Interaction between smoking and PON2 Ser311Cys polmorphism as a determinant of the risk of myocardial infaretion显示文摘Matinelli M Girelli D Olivieri O 2004Eur J Clin Invest2004,34,1:1
3Circulating inflamma-miRs in aging and age-related diseases显示文摘Olivieri F Rippo M R Procopio A D 2013Front Genet2013,4,:1
4Aldosterone to renin ratio in a primary care setting:the Bussolengo study显示文摘Olivieri O Ciaeciarelli A Signorelli D 2004J Clin Endoctinol Metab2004,89,9:1
5The airway neurogenic inflammation:clinical and pharmacological implications显示文摘Pisi G Olivieri D Chetta A 2009Inflamm Allergy Drug Targets2009,8,3:1
6Oxidative stress in the pathogenesis of diffuse lung diseases:A review显示文摘Bargagli E Olivieri C Bennett D 2009Respir Med2009,103,9:1
71D graphene-like silicon systems:silicene nano-ribbons显示文摘Padova P D Perfetti P Olivieri B 2012J Phys:Condens Matter2012,24,22:1
8An in vivo RNAi assay identifies major genetic and cellular requirements for primarypiRNA biogenesis in Drosophila显示文摘OLIVIERI D SYKORA M M SACHIDANANDAM R 2010EMBOJ2010,29,19:1
9Successful treatment of recalcitrant genital ulcers of Behcet's disease with adalimumab after fail- ure of infliximab and elanereept 显示文摘Olivieri I D'Angelo S Padula A 2009Clin Exp Rheumatol2009,27,2153:1
10Late-onset rheumatoid arthritis and late-onset spondyloarthritis 显示文摘Olivieri I Pipitone N D'Angelo S 2009Cliu Exp Rheumatol2009,27,4:1
11Air particulate matter and cardiovascular disease : a narrative review 显示文摘MARTINELLI N OLIVIERI O GIRELLI D 2013Eur J Intern Med2013,24,:1
12Effect of short-term treatment with low-dose in-haled flutieasone propionate on airway inflammation and remode-ling in mild asthma: a placebo-controlled study显示文摘Olivieri D Chetta A Del Donno M BertoreLli G Casalini A Pesci A 1997Am J Respir Crit Care Med1997,155,6:1
13显示文摘 D' Ippolito R Chetta A 2000Curr Opin Pulm Med2000,6,5:1
14Diagnostic invasive procedures in diffuse infiltrative lung diseases显示文摘Poletti V Chilosi M Olivieri D 2004Respiration2004,71,:1
15Oxidative stress in thepathogenesis of diffuse lung diseases: a review 显示文摘Bargaglie E Olivieri C Bennett D 2009Respir Med2009,103,9:1
16Anti-oxidant status and lipid peroxidation in patients with essential hypertension显示文摘Russo C Olivieri O Girelli D 1998J Hypertens1998,16,:1
17Air particulate matter and cardiovascular disease: a narrative review显示文摘Martinelli N Olivieri O Girelli D 2013Eur J Intern Med2013,24,:1
18Interest of Chro- mogranin A for diagnosis and follow-up of endocrine tumours 显示文摘Nehar D Lombard-Bohas C Olivieri S 2004Clin Endocrinol (Oxf)2004,60,5:1
19Estimation of pathogen removal in an advanced water treatment facility using Monto Carlo simulation显示文摘Olivieri A Eisenberg D SoUer J etal 1999Water Science and Technology1999,40,45:1
20Aldosterone to renin ratio in a primary care setting:the Bussolengo study 显示文摘Olivieri O Ciacciarelli A Signorelli D 2004J Clin Endocrinol Metab2004,89,:1
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