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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017，23，2： | 16 |
| 2 | Percutaneous ablation of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of nonresectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction. The aim of this article will be to describe the multiple currently available treatment techniques(radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation), their results, and their possible complications, with the aid of a literature review. | Mirko D'Onofrio Valentina Ciaravino Riccardo De Robertis Emilio Barbi Roberto Salvia Roberto Girelli Salvatore Paiella Camilla Gasparini Nicolò Cardobi Claudio Bassi | 2016 | World Journal of Gastroenterology2016，22，44： | 7 |
| 3 | Radiofrequency ablation of locally advanced pancreatic adenocarcinoma:An overview显示文摘Radiofrequency ablation(RFA)of pancreatic neoplasms is restricted to locally advanced,non-resectable but nonmetastatic tumors.RFA of pancreatic tumors is nowadays an ultrasound-guided procedure performed during laparotomy in open surgery.Intraoperative ultrasound covers the mandatory role of staging,evaluation of feasibility,guidance and monitoring of the procedure.Different types of needle can be used.The first aim in the evaluation of RFA as a treatment for locally advanced pancreatic ductal adenocarcinoma,in order of evaluation but not of importance,is to determine the feasibility of the procedure.The second aim is to establish the effect of RFA on tumoral mass in terms of necrosis andcytoreduction.The most important aim,third in order of evaluation,is the potential improvement of quality of life and survival rate.Nowadays,only a few studies assess the feasibility of the procedure.The present paper is an overview of RFA for pancreatic adenocarcinoma. | Mirko D’Onofrio Emilio Barbi Roberto Girelli Enrico Martone Anna Gallotti Roberto Salvia Paolo Tinazzi Martini Claudio Bassi Paolo Pederzoli Roberto Pozzi Mucelli | 2010 | World Journal of Gastroenterology2010，16，28： | 6 |
| 4 | Interaction between smoking and PON2 Ser311Cys polmorphism as a determinant of the risk of myocardial infaretion显示文摘 | Matinelli M Girelli D Olivieri O | 2004 | Eur J Clin Invest2004，34，1： | 1 |
| 5 | Methylenetetrahydrofolate reductase C677T mutation,plasma homocysteine,and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease:evidence for an important genetic-environmental interaction显示文摘 | Girelli D Friso S Trabetti E | 1998 | Blood1998，91，： | 1 |
| 6 | Sleep disorders in advanced cancer patients: prevalence and factors associated显示文摘 | Mercadante S Girelli D Casuceio A | 2004 | Support Care Cancer2004，12，5： | 1 |
| 7 | A common mutation in the 5, 10-methylenetetrahydro folate reductase gene affects genomic DNA methylation through an interaction with folate status 显示文摘 | Friso S Choi SW Girelli D | 2002 | Proc Nat Acad Sci USA2002，99，8： | 1 |
| 8 | ALOX5AP gene variants and risk of coronary artery disease: an angiography- based study显示文摘 | Girelli D Maxtinelli N Trabetti E | 2007 | Eur J Hun Genet2007，15，9： | 1 |
| 9 | Modulation of factor Ⅶ levels byintron 7 polymorphlsm: populantion and in vitro stodles显示文摘 | Pinotti M Toso R Girelli D | 2000 | Blood2000，95，11： | 1 |
| 10 | FADS genotypes and de saturase activity estimated by the ratio of arachidonic acid to lino leic acid are associated with inflammation and coronary artery dis ease显示文摘 | Martinelli N Girelli D Malerba G | 2008 | Am J Clin Nutr2008，88，4： | 1 |
| 11 | A common mutation in the 5,10-methyl enetetrahydro folate reductase gene affects genomic DNA methylation through an interaction with folate status显示文摘 | Friso S Choi SW Girelli D | 2002 | Proc Natl Acad Sci U S A2002，99，8： | 1 |
| 12 | New high performance phos-phites显示文摘 | Costanzi S Farris R Girelli D | 2001 | Polymer Degradation and Stability2001，73，3： | 1 |
| 13 | Hepcidin levels and their deter-minants in different types of myelodysplastic syndromes 显示文摘 | Santini V Girelli D Sanna A | 2011 | PlosOne2011，6，23： | 1 |
| 14 | Air particulate matter and cardiovascular disease : a narrative review 显示文摘 | MARTINELLI N OLIVIERI O GIRELLI D | 2013 | Eur J Intern Med2013，24，： | 1 |
| 15 | Polymorphisms in the factor Ⅶ gene and the risk of myocardial infarction in patients with coronary artery disease显示文摘 | Girelli D Russo C Ferraresi P | 2000 | N Engl J Med2000，343，11： | 1 |
| 16 | Polymorphisms in the factor Ⅶ gene and the risk of myocardial infarction in patients with coronary artery disease显示文摘 | Girelli D Russo C Ferraresi P | 2000 | N Eng1 J Med2000，343，9： | 1 |
| 17 | Immunoassay for human serum hepcidin显示文摘 | GANZ T OLBINA G GIRELLI D | 2008 | Blood2008，112，10： | 1 |
| 18 | HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients显示文摘 | Valenti L Girelli D Valenti GF | 2009 | Clin J Am Soc Nephrol2009，4，8： | 1 |
| 19 | A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease:relationships with C677T polymorphism and homocysteine/folate metabolism显示文摘 | Friso S Girelli D Trabetti E | 2002 | Clin Exp Med2002，2，1： | 1 |
| 20 | Polymorphisms in the factor VII gene and the risk of myocardial infarct ion in pa- tients with coronary artery disease显示文摘 | Girelli D Russo C Ferraresi P | 2000 | N Engl J Med2000，343，9： | 1 |
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