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| 1 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 2 | Chromatin protein HMGB2 regulates articular cartilage surface maintenance via β-catenin pathway显示文摘 | Noboru Taniguchi Beatriz Caramés Yasuhiko Kawakami | | 0，，： | 1 |
| 3 | Endogenous Cannabinoids are Candidates for Lipid Mediators of Bone Cement Implantation Syndrome显示文摘 | Takashi Motobe Teruto Hashiguchi Tomonori Uchimura Munekazu Yamakuchi Noboru Taniguchi Setsuro Komiya Ikuro Maruyama | 2004 | Shock2004，，1： | 1 |
| 4 | Microwave Heating Behavior of Blast Furnace Slag Beating High TiO2 显示文摘 | CHEN Yan Noboru Yoshikawa Shoji Taniguchi | 2005 | ISIJ Int2005，45，9： | 1 |
| 5 | Microwave Heating Behavior of Blast Furnace Slag Bearing High TiO2显示文摘 | Chen Yan Noboru Yoshikawa Shoji Taniguchi | 2005 | ISIJ International2005，45，9： | 1 |
| 6 | Pre-procedural evaluation of the left atrial anatomy in patients referred for catheter ablation of atrial fibrillation显示文摘 | Yoshihisa Kanaji Shinsuke Miyazaki Jin Iwasawa Noboru Ichihara Takamitsu Takagi Akio Kuroi Hiroaki Nakamura Hiroshi Taniguchi Hitoshi Hachiya Yoshito Iesaka | 2015 | Journal of Cardiology2015，，： | 1 |
| 7 | Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif显示文摘 | Masashi Taniguchi Kyoko Fujiwara Yuji Nakai Toshinori Ozaki Nobuko Koshikawa Kojima Toshio Motoaki Kataba Asako Oguni Hiroyuki Matsuda Yukihiro Yoshida Yasuaki Tokuhashi Noboru Fukuda Takahiro Ueno Masayoshi Soma Hiroki Nagase | 2014 | FEBS Open Bio2014，，： | 1 |
| 8 | Fabrication of Porous SiO_2·RO/SUS Composite Body for DPF (Diesel Particulate Filter) and Microwave Heating Behavior显示文摘Glass/stainless steel porous composite body were prepared by the polyurethane sponge replica method using slurries containing mixture of SiO_2-RO/30 vol%SUS.Sintered porous samples were obtained which consists of well-distributed stainless steel particles within the glass matrix.Such a microstructure is desired for the purpose as a soot particulate filters(DPF)utilizing microwave rapid heating in cold start phase.Heating ability of the fabricated porous composite body was carried out placing the specimen in the maximum H-field of a 2.45 GHz single mode applicator.Heating behavior of the samples was mainly influenced by the volume fraction of stainless steel.Higher heating rate was observed for samples with higher stainless steel fraction.Due to the different microwave absorbability of the materials,stainless steel particle in the porous matrix structure was firstly heated up by microwave and transferred the heat energy throughout the whole sample.Increasing of the fraction of the stainless steel particle in the matrix structure led the better heating;however the strength of the samples decreased. | LEE Chang Chuan ICHIHASHI Yuma YOSHIKAWA Noboru TANIGUCHI Shoji | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 0 |
| 9 | Recent Researches on Microwave Processing for Materials and Environmental Technology in Our Group显示文摘Microwave processing has been taken into consideration for various purposes,not only for cooking,drying and enhancement of solution reaction kinetics but also various high temperature processes.In the presentation,selected research projects conducted in our group will be reported.The first topic is the microwave processing for recycling valuable metals from by-products originated in the iron and steel industries.We studied microwave application to handling of the pickling sludge,which occurs in stainless steel rolling process.Microwave use for dehydration and carbo-thermic reduction processes was attempted.Next,because Pb elution from the wasted funnel glass used for the cathod-ray tube is one of the serious environmental problems,microwave application to leaching process of Pb from a Pb-conatining glass was performed.The kinetic study of the acid dissolution was performed.Last topic is fabrication of filter material for burning particulate matter(PM)from diesel engine(Diesel Particulate Filter:DPF).Microwave rapid heating characteristics are applied to the cold start(ignition)condition of engine for prevention of PM emission. | Yoshikawa Noboru Keita Kawahira Kazuya Fujino Lee Chang Chuan Shoji Taniguchi | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 0 |
| 10 | Combustion Synthesized Porous Body of Fe_3O_4/Al System by Controlled Microwave Heating and Heating Behavior of the Products显示文摘Microwave-induced substitutional combustion reaction was utilized to fabricate porous ceramic composite from Fe_3O_4/Al powder mixtures.The porous composite body was obtained by controlling the combustion reaction progress in a 2.45 GHz single mode applicator.Prior to the fabrication of the porous body,heating behavior of the powder mixtures were studied in the separated electric(E)and magnetic(H)fields.In addition,heating ability of the microwave fabricated porous product was also investigated.Fe_3O_4powder can be heated up easily in both maximum H and E field,but a better heating was observed in the maximum H field.Regardless of the mixtures ratio(mixing compositions),maximum H field shows better heating characteristics.In E-field heating,temperature of the Fe_3O_4 samples decreased sharply when Al powder was added.However,the same phenomenon was not observed in the maximum H field heating.Thus,fabrication of the porous composite body was carrying out in maximum H field.Through an adequate control of the reaction progress,products with a porous structure consisting of well-distributed metal particles in the alumina and/or hercynite matrix were obtained.Consequently,heating of the fabricated porous composite body was also been successfully carried out in the maximum H field.Product phases and microstructure were the main factors influencing the heating ability of the porous composite body. | LEE Chang Chuan YOSHIKAWA Noboru TANIGUCHI Shoji | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 0 |
| 11 | Interaction of Microwave Magnetic Field With Materials显示文摘Microwave is an electromagnetic wave and consists of the electric and the magnetic fields.The microwave electric field interacts with dielectric materials and heat is generated due to the dielectric loss,which is a major mechanism of microwave heating of water.Microwave magnetic field interaction with materials has to be discussed in terms of two different mechanisms.The first class is the induction current generation in(mainly)metallic materials,which gives rise the Joule heat,although the penetration distance into metals are limited within a microns or less.In this article,a characteristic application of microwave induction heating of metal thin film is presented.The second class is the microwave interaction with the ferro(or ferri)magnetic materials.Effect of ferromagnetic resonance(FMR)is taken into consideration as the fundamental heating mechanism of the ferro-magnetic materials.The FMR heating behavior of Fe_3O_4 is presented.Discussion is made for the phenomena observed in the experiments. | Yoshikawa Noboru Tomotsugu Kato Shoji Taniguchi | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 0 |
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