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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY):two randomised trials显示文摘 | Noble PW Albera C Bradford WZ | | 0，，9779： | 2 |
| 3 | Characterization of highly stable liposomal and immunoliposornal for mulations of vineristine and vinblastine 显示文摘 | Noble C O Guo Z Hayes M E | 2009 | Cancer Chemoth Pharm2009，64，4： | 1 |
| 4 | Investigation of the effect of skin contact time on wine flavour显示文摘 | SCHMIDT J O NOBLE A C | 1983 | The American Journal of Enology and Viticulture1983，34，3： | 1 |
| 5 | Evaluation of a general practitioner with special interest service for dermatology:randomised controlled trial显示文摘 | Salisbury C Noble A Horrocks S | 2005 | BM J2005，331，： | 1 |
| 6 | Dikehosted ores of the Beast deposit and the importance of Eocene magmatism in gold mineralization of the Carlin trend, Nevada 显示文摘 | Ressel M W Noble D C Henry C D | 2000 | Economic Geology2000，，95： | 1 |
| 7 | Role of chance observations in chemotherapy : Vincarosea 显示文摘 | Noble R L Beer C T Cutts J H | 1958 | Ann N Y Acda Sci1958，76，3： | 1 |
| 8 | Journal of the Less-Common Metals显示文摘 | Harris I R Noble C | 1985 | 106:L1-L41985，106，： | 1 |
| 9 | Pirfenidone in patients with idiopathic pulmonary fibrosis(CAPACITY):two randomised trials显示文摘 | Noble PW Albera C Bradford WZ | 2011 | Lancet2011，377，9779： | 1 |
| 10 | The Influence of C2C Communications in Online Brand Communities on Customer Purchase Behavior显示文摘 | Adjei M Noble S Noble C | | 0，，05： | 1 |
| 11 | Pirfenidone in patients with idiopathic pulmonary fibrosis(CAPACITY):two randomised trials显示文摘 | NOBLE PW ALBERA C BRADFORD WZ | 2011 | Lancet2011，377，9779： | 1 |
| 12 | Mitosis-meiosis and sperm-oocyte fate decisions are separable regulatory events显示文摘 | MORGAN C T NOBLE D KIMBLE J | 2013 | Proc Natl Acad Sci U S A2013，110，9： | 1 |
| 13 | Cancer stem cells显示文摘 | Jordan C T Guzman M L Noble M | 2006 | N Engl J Med2006，355，12： | 1 |
| 14 | Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury显示文摘 | Davies S J Shih C H Noble M | 2011 | PLoS One2011，6，17： | 1 |
| 15 | Dike - hosted ores of the Beast deposit and the importance of Eocene magmatism in gold mineralization of the Carlin trend, Nevada--a reply 显示文摘 | Ressel M W Noble D C Henry C D | 2001 | E- conomic Geology2001，，96： | 1 |
| 16 | Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats 显示文摘 | YAU JL NOBLE J HIBBERD C | 2002 | J Neurosci2002，22，4： | 1 |
| 17 | Separation of light gas mixtures using SAPO-34membranes显示文摘 | Poshusta J C Tuan V A Pape E A Noble R D Falconer J L | 2000 | AIChE Journal2000，46，4： | 1 |
| 18 | Enantiospecific synthesis of 3'-hetero-dideoxynu- cleoside analogues as potential anti-HIV agents显示文摘 | JONES M F NOBLE S A ROBERTSON C A | 1992 | J Chem Soc Perkin Trans 11992，11，： | 1 |
| 19 | A new technique for measuring pulmonary edema显示文摘 | NOBLE W H OBDRZALEK J KAY J C | 1973 | J Appl Physiol1973，34，4： | 1 |
| 20 | The morphology of thefemur in development dysplasia of the hip显示文摘 | Philip C Noble NS Emir Kamaric | 1998 | Journal of Bone and Joint Surgery1998，80，： | 1 |
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