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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | The influence of SiC reinforcement on pitting behavior of aluminum显示文摘 | Trowsdale A J Noble B Harris S J Gibbins I S R | 1996 | Corrosion Science1996，38，： | 2 |
| 3 | Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis显示文摘 | Simon IR Noble Mike D Shelley Bernadette Coles Susan M Williams Andrew Wilcock Miriam J Johnson | 2008 | Lancet Oncology2008，，6： | 2 |
| 4 | Second-line or subsequent systemic therapy for recurrent or progessive non-small cell lung cancer:a systematic review and practice guideline显示文摘 | Noble J | 2006 | Thoracic Oncol2006，1，： | 1 |
| 5 | Images as Functions and Sets显示文摘 | Noble J A | 1992 | Image and Vision Comput1992，10，1： | 1 |
| 6 | Role of allergy in nasl polyosis:a review显示文摘 | Gorfien J Noble B | 1995 | Otolaryngol Head Neck Surg1995，113，6： | 1 |
| 7 | Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer: a systematic review and practice guideline 显示文摘 | Noble J | 2006 | Thoracic Oncol2006，1，： | 1 |
| 8 | A new technique for measuring pulmonary edema显示文摘 | Noble WH Obdrzalek J Kay JC | 1973 | J Appl Physiol1973，34，4： | 1 |
| 9 | Role of allergy in nasal polypsis: a review显示文摘 | Bernstein JM Gorfien J Noble B | 1995 | Otolaryngol head neck surg1995，113，： | 1 |
| 10 | Myocardial bridging and milk effect of the left anterior descending artery: nomalvariant or obstruction 显示文摘 | Noble J Bourassa MG Pettclerde R | 1976 | Am J Cardiol1976，37，： | 1 |
| 11 | Hyaluronan in tissue injury and repair 显示文摘 | Jiang D Liang J Noble P W | 2007 | Annu Rev Cell Dev Biol2007，23，： | 1 |
| 12 | Finding comers 显示文摘 | J A Noble | 1988 | Image Computing1988，6，2： | 1 |
| 13 | Outcome of trabeeulectomy with intraoperative mitomycin C for uveitic glaucoma显示文摘 | Noble J Derzko-Dzulynsky L Rabinovitch T | 2007 | Can J Ophthalmol2007，42，1： | 1 |
| 14 | The impact of residual coagulant on downstream treatment process 显示文摘 | Lees E J Noble B Hewitt R | 2001 | Environment Technology2001，22，1： | 1 |
| 15 | Dislocations of the lunate with and without fracture of the scaphoid显示文摘 | Panting AL Lamb DW Noble J | 1984 | J Bone Joint Surg Br1984，66，3： | 1 |
| 16 | Myocardial bridging and milking effect of the left anterior descending coronary artery: Nor- mal variant or obstruction 显示文摘 | Noble J Bourassa MG Petitclere R | 1976 | Am J Cardio1976，37，7： | 1 |
| 17 | Fabrication of 'hairy' colloidosomes with shells of polymeric microrods显示文摘 | Noble P F Cayre O J Alargova R G | 2004 | Journal of the American Chemical Society2004，126，26： | 1 |
| 18 | Investigation of the effect of skin contact time on wine flavour显示文摘 | SCHMIDT J O NOBLE A C | 1983 | The American Journal of Enology and Viticulture1983，34，3： | 1 |
| 19 | Rapid one-step quantitative reverse transcriptase PCR assay with competitive internal positive control for detection of enteroviruses in environmental samples 显示文摘 | GREGORY J B LITAKER R W NOBLE R T | 2006 | Appl Environ Microbiol2006，72，6： | 1 |
| 20 | The relationship between the strength of the humen heart beat and the interval between beats 显示文摘 | Pidgeon j Miller GAH Noble MIM | 1982 | Circulation1982，65，7： | 1 |
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