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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 3 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 4 | Comparison of mineral-based amendments for ex-situ stabilization of trace elements (As, Cd, Cu, Mo, Ni, Zn) in marine dredged sediments: A pilot-scale experiment显示文摘 | Yannick Mamindy-Pajany Charlotte Hurel Florence Geret Michèle Roméo Nicolas Marmier | 2013 | Journal of Hazardous Materials2013，，： | 2 |
| 5 | Fluctuations in bovine o- varian follicular fluid composition throughout the oestrous cycle 显示文摘 | NICOLAS M O NADIA G HENRY J L | 2005 | Reproduction2005，129，： | 1 |
| 6 | Preferential Oxidation of Carbon Monoxide in the Presence of Hydrogen (PROX) over Noble Metals and Transition Metal Oxides: Advantages and Drawbacks显示文摘 | Nicolas Bion Florence Epron Máximo Moreno Fernando Mari?o Daniel Duprez | 2008 | Topics in Catalysis (-)2008，，1： | 1 |
| 7 | Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer A systematic review with meta-analysis显示文摘 | Des Guetz G Schischmanoff O Nicolas P | | 0，，10： | 1 |
| 8 | An efficient tool for predicting the structural acoustic and vibration response of sandwich plates in light or heavy fluid显示文摘 | Foin O Nicolas J Atalla N | 1999 | Applied Acoustics1999，57，： | 1 |
| 9 | Vibrio car- chariae, a pathogen of the abalone Haliotis tuberculata 显示文摘 | NICOLAS J L BASUYAUX O MAZURIE J | 2002 | Dis Aquat Org2002，50，1： | 1 |
| 10 | Estrogenicity of resin based composites and sealants used in dentistry 显示文摘 | Nicolas O Rosa P pilar P | 1996 | Envion Health Perspect1996，104，： | 1 |
| 11 | Pollution by hexachlo-robenzene and pentachlorophenol in the coastat plain of Sāo Paulo state显示文摘 | Nascimento N R Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，34： | 1 |
| 12 | Endometrial metap显示文摘 | Nicolae A Preda O Nogales FF | 2011 | J Clin Pathol2011，64，2： | 1 |
| 13 | Clinical Trials in Coronary Angiogenesis: Issues,Problems,Consensus: An Expert Panel Summary显示文摘 | Simons Michael Bonow Robert O Chronos Nicolas A | 2000 | Circulation2000，102，11： | 1 |
| 14 | Co- rporate-NGO Collaboration:Co-creating New Business Models for Developing Markets 显示文摘 | NICOLAS M D JONATHAN P D JENNIFER O | 2010 | Long Range Planning2010，43，23： | 1 |
| 15 | Biosensing using lipid bilayers suspended on porous silicon 显示文摘 | WORSFOLC O VOELCKER NICOLAS H | 2006 | Langmuir2006，22，16： | 1 |
| 16 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state, Brazil 显示文摘 | do Nascimento N R Nicola S M C Rezende M 0 O | 2004 | Geoderma2004，121，34： | 1 |
| 17 | Compaction of a granular material under cyclic shear 显示文摘 | Nicolas M Duru P Pouliquen O | 2000 | The European Physical Journal E2000，3，4： | 1 |
| 18 | Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients显示文摘 | Ronald F van Vollenhoven Paul Emery Clifton O Bingham Edward C Keystone Roy M Fleischmann Daniel E Furst Nicola Tyson Neil Collinson Patricia B Lehane | 2013 | Annals of the Rheumatic Diseases2013，，9： | 1 |
| 19 | Design of protein membrane interaction inhibitors by virtual ligand screening,proof of concept with the C2 domain of factor Ⅴ显示文摘 | Segers K Sperandio O Sack M Fischer R Miteva M A Rosing J Nicolaes G A Villoutreix B O | | 0，，： | 1 |
| 20 | Cardiovascular Risk Factors and Disease Management in Type 2 Diabetic Patients With Diabetic Nephropathy显示文摘 | Sasso FC De Nicola L Carbonara O | 2006 | Diabetes Care2006，29，3： | 1 |
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