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| 1 | NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro显示文摘 | Wen-juan WANG Lin-mei LONG Neng YANG Qing-qing ZHANG Wen-jun JI Jiang-hu ZHAO Zheng-hong QIN ZhongWANG Gang CHEN Zhong-qin LIANG | 2013 | Acta Pharmacologica Sinica2013，34，5： | 14 |
| 2 | The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats显示文摘Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. | MIAO Zhu Lin GUO Liang WANG Yong Xia CUI Rong YANG Ning HUANG Mi Qiong QIN Wei Bing CHEN Jin LI Hong Mei WANG Zi Neng WEI Xiang Cai | 2012 | Biomedical and Environmental Sciences2012，25，1： | 14 |
| 3 | Spatial Pattern Evolution and Casual Analysis of County Level Economy in Changsha-Zhuzhou-Xiangtan Urban Agglomeration, China显示文摘In order to evaluate whether or not the county units′ economy in the Changsha-Zhuzhou-Xiangtan(Chang-Zhu-Tan) Urban Agglomeration was growing as expected, this study analyzed the spatial economy pattern at county-level by using the Exploratory Spatial Data Analysis(ESDA) method. In this process, the global Moran′s I and local Getis-Ord G*i indexes were employed to analyze indicators including per capita GDP and three industrials(i.e. primary, secondary and tertiary industry) from 2000 to 2010. The results show that: 1) the county units′ economy in the Chang-Zhu-Tan Urban Agglomeration has exhibited a strong spatial autocorrelation and an accelerated integration trend since 2008(Moran′ s I increased from 0.26 to 0.56); 2) there is a significant difference in economy development between the northern and southern county units in the Chang-Zhu-Tan Urban Agglomeration: the hotspot zone with high economic level was formed among the northern county units whereas the coldspot zone with low economic level was located in the southern areas. This difference was caused primarily by the increasingly prominent economic radiation effect of Changsha ′upheaval′; 3) town density, secondary industry, and the integration policy are the major contributors driving the evolution of the spatial economy pattern in the Chang-Zhu-Tan Urban Agglomeration. | DONG Minghui ZOU Bin PU Qiang WAN Neng YANG Lingbin LUO Yanqing | 2014 | Chinese Geographical Science2014，24，5： | 8 |
| 4 | Synthesis, mechanical investigation, and application of nitrogen and phosphorus co-doped carbon dots with a high photoluminescent quantum yield显示文摘有高 photoluminescent 量收益(PLQY ) 的做 Heteroatom 的碳点(CD ) 最近在化学传感器,光催化, bioimaging,和药交货中由于他们的应用吸引了注意。氮和磷在到在周期表的碳的靠近的最近并且是关键的在生物医学的成像的地里追踪元素。这二个元素改变 CD 的光、电子的性质并且帮助改进他们的 PLQY 的基本理解。这能也在 photoimaging 和 photothermal 治疗导致多功能的用法。然而,源于做 P 的 CD 的合成的大多数 PLQY 当前低于 50% 。这些 CD 在 bioimaging 和药交货的地里限制了实用性。在这研究,一个单个步的、高效率的热水的方法被使用综合氮和磷药的碳点((N, P ) 有有独立排放的多达 53.8% 的 PLQY 的 -CDs) 行为。而且, CD 在一个大 pH 范围上介绍了高 monodispersity,柔韧的刺激无关的光,和稳定性。分光镜的调查显示 PLQY (N, P ) CD 主要由于 P 的增加和氧化表面的钝化效果。优秀荧光性质(N, P ) CD 能被 Hg 2+ 离子有效地并且有选择地熄灭。如此的系统与一短反应时间在 0-900 nM 集中范围显示出线性回答,显示他们为化学和生物学的领域里的应用程序的潜力。 | Quan Xu Bofan Li Yingchun Ye Wei Cai Weijun Li Chuanyao Yang Yusheng Chen Meng Xu Neng Li Xusheng Zheng Jason Street Yan Luo Lulu Cai | 2018 | Nano Research2018，11，7： | 7 |
| 5 | Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in prevention of autoimmune diabetes in non-obese diabetic mice treated with α- galactosylceramide显示文摘 | Weipeng Li Fang Ji Yong Zhang Ying Wang Neng Yang Hailiang Ge Fuqing Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 5 |
| 6 | Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-KB signaling pathway显示文摘 | Neng YANG Pan WANG Wen-juan WANG Yun-zhen SONG Zhong-qin LIANG | 2015 | Acta Pharmacologica Sinica2015，36，3： | 5 |
| 7 | Month-Wise Prevalence of Subclinical Mastitis in Dairy Cows in Guangdong Province,China显示文摘To evaluate the month-wise prevalence of subclinical mastitis (SM) and its relations with climatic temperature and humidity, and to provide references for control and prevention of mastitis in dairy cows in Guangdong, China, California mastitis test method was used to determine the monthly prevalence of SM (MPSM, %) of lactating Holstein cows from 11 dairy farms in Guangdong Province, China, including about 516 cows per monthly examination. The average MPSM on a cow and a quarter basis were 30 and 13% respectively, and there was a positive linear correlation between monthly mean air temperature (MT, °C) and MPSM on a cow basis (r=0.763, P=0.004) or a quarter basis (r=0.577, P=0.049), but there were no correlations between MT and MPSM on a cow or a quarter basis (P>0.05). There was a shift in MPSM trend that the highest MPSM (38.4%) was not for the hottest July with MT at 30.8°C, but for the later September at 27.9°C. The farms need to develop new housing conditions to control cowshed temperatures in the hot season to reduce the mastitis prevalences in the post-hot months. | YANG Jin-bo WEI Neng WEN Liu-fa | 2012 | Journal of Integrative Agriculture2012，11，1： | 5 |
| 8 | Structural patterns of fault damage zones in carbonate rocks and their influences on petroleum accumulation in Tazhong Paleo-uplift, Tarim Basin, NW China显示文摘Based on the outcrop survey,3D seismic data interpretation,drilling data analysis,the structural patterns and distribution of fault damage zones in carbonate strata of Tazhong Paleo-uplift were established to reveal the oil and gas enrichment law in the fault damage zones.The following findings were reached:(1)Through the filed survey,the fault damage zone system consists of fault core,damage zone with branch fault and fracture network.Affected by the active nature of the major faults,the fault damage zones differ in planar pattern and scale along the major faults.(2)3D seismic profiles reveal that there are three types of fault damage zones in carbonate strata in Tazhong paleo-uplift,strike-slip fault damage zones,thrust fault damage zones and superimposed fault damage zones.Featuring3 flowers and 3 root belts in vertical,the strike-slip fault damage zone can be subdivided into linear type,oblique type,feather type and horsetail type in plane.Thrust fault damage zones can be further divided into fault anticline type,anticline type and slope type.As the superimposition result of the above two kinds of fault damage zones,superimposed fault damage zones appear in three patterns,intersect type,encompassment type and penetrating type.(3)Cores from wells and geochemical data show oil and gas may migrate along the major fault and laterally.The feather type in strike-slip fault system,fault anticline type in thrust fault damage zone and intersect type in superimposed fault damage zone are possible sites for high production and efficiency wells. | NENG Yuan YANG Haijun DENG Xingliang | 2018 | Petroleum Exploration and Development2018，45，1： | 4 |
| 9 | Conductive photo-thermal responsive bifunctional hydrogel system with self-actuating and self-monitoring abilities显示文摘Despite enormous efforts in actuators,most researches are only limited to various actuation behaviors and demonstrations of soft materials.It has not yet been reported to capture and monitor its movement status in an invisible environment.Therefore,it is of great significance to develop a self-sensing and self-actuating dual-function hydrogel actuator system to realize real-time monitoring.Here,we report a bifunctional hydrogel system with self-actuating and self-monitoring abilities,which combines the functions of photothermal actuation and electrical resistance sensing into a single material.The bilayer tough conductive hydrogel synthesized by unconventional complementary concentration recombination and cryogenic freezing technique presents a dense conductive network and high-porosity structure,achieving high toughness at 190.3 kPa of tensile strength,high stretchability(164.3%strain),and the toughness dramatically(1,471.4 kJ·m^(−3)).The working mechanism of the monitoring and self-sensing system is accomplished through the integrated monitoring device of surface temperature–bending angle–electron current,to solve the problem of not apperceiving actuator motion state when encountering obstacles in an invisible environment.We demonstrated for the first time a photothermal actuator’s motion of a football player and goalkeeper to finish the penalty and a soft actuator hand,which can achieve the action of sticking to grab and release under photo-thermal actuation.When connected to the control closed circuit,the actuator realized closed-loop monitoring and sensing feedback.The development of bifunctional hydrogel systems may bring new opportunities and ideas in the fields of material science,circuit technology,sensors,and mechanical engineering. | Neng Chen Yang Zhou Yinping Liu Yuanyuan Mi Sisi Zhao Wang Yang Sai Che Hongchen liu FengJiang Chen Chong Xu Guang Ma Xue Peng Yongfeng Li | 2022 | Nano Research2022，15，8： | 3 |
| 10 | Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage显示文摘 | Qing-qing ZHANG Wen-juan WANG Jun LI Neng YANG Gang CHEN Zhong WANG Zhong-qin LIANG | 2015 | Acta Pharmacologica Sinica2015，36，9： | 3 |
| 11 | Accumulated Clinical Experiences from Successful Treatment of 1377 Severe and Critically Ill COVID-19 Cases显示文摘Summary:In late December 2019,COVID-19 was firstly recognized in Wuhan,China and spread rapidly to all of the provinces of China.The West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the severe and critically ill COVID-19 cases,has treated a large number of such patients with great success and obtained lots of valuable experiences based on the Chinese guideline(V7.0).To standardize and share the treatment procedures of severe and critically ill cases,Wuhan Union Hospital has established a working group and formulated an operational recommendation,including the monitoring,early warning indicators,and several treatment principles for severe and critically ill cases.The treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world. | Yong GAO Hai-bo QIU Shu ZHOU Zhen-ning WANG Jian-chu ZHANG Zheng-liang ZHANG Zhao-xin QIAN Hong-bo WANG Shi-huan YU Yi-feng LUO Ya dan WANG Zhuang LIU Wei-ci WANG Ming JIA Li-ming ZHANG Yu ZHANG Yang JIN Yong ZHANG Yong LIU Zi-hua ZHOU Ying SU Hui-qing LI Wei-min XIAO Kai HUANG Ping HE Gang LI Zhao-hui FU Shi LIU Neng xing LIN Fan-jun CHENG | 2020 | Current Medical Science2020，40，4： | 2 |
| 12 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 13 | Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling显示文摘 | Li QIN Yun-bo YANG Yi-xin YANG Neng ZHU Yong-zhen GONG Cai-ping ZHANG Shun-xiang LI Duan-fang LIAO | 2014 | Acta Pharmacologica Sinica2014，35，9： | 2 |
| 14 | Strategic design and fabrication of MXenes-Ti_(3)CNCl_(2)@CoS_(2) core-shell nanostructure for high-efficiency hydrogen evolution显示文摘CoS_(2) is considered to be a promising electrocatalyst for hydrogen evolution reaction(HER).However,its further widespread applications are hampered by the unsatisfactory activity due to relatively high chemisorption energy for hydrogen atom.Herein,theoretical predictions of first-principles calculations reveal that the introduction of a Cl-terminated MXenes-Ti_(3)CNCl_(2) can significantly reduce the HER potential of CoS_(2)-based materials and the Ti_(3)CNCl_(2)@CoS_(2) core–shell nanostructure has Gibbs free energy of hydrogen adsorption(|ΔGH|)close to zero,much lower than that of the pristine CoS_(2) and Ti_(3)CNCl_(2).Inspired by the theoretical predictions,we have successfully fabricated a unique Ti_(3)CNCl_(2)@CoS_(2) core–shell nanostructure by ingeniously coupling CoS_(2) with a Cl-terminated MXenes-Ti_(3)CNCl_(2).Interface-charge transfer between CoS_(2) and Ti_(3)CNCl_(2) results in a higher degree of electronic localization and a formation of chemical bonding.Thus,the Ti_(3)CNCl_(2)@CoS_(2) core–shell nanostructure achieves a significant enhancement in HER activity compared to pristine CoS_(2) and Ti_(3)CNCl_(2).Theoretical calculations further confirm that the partial density of states of CoS_(2) after hybridization becomes more non-localized,and easier to interact with hydrogen ions,thus boosting HER performance.In this work,the success of oriented experimental fabrication of high-efficiency Ti_(3)CNCl_(2)@CoS_(2) electrocatalysts guided by theoretical predictions provides a powerful lead for the further strategic design and fabrication of efficient HER electrocatalysts. | Jizhou Jiang Saishuai Bai Meiqing Yang Jing Zou Neng Li Jiahe Peng Haitao Wang Kun Xiang Song Liu Tianyou Zhai | 2022 | Nano Research2022，15，7： | 2 |
| 15 | Target alignment in the Shen-Guang Ⅱ Upgrade laser facility显示文摘The Shen-Guang II Upgrade(SG-Ⅱ-U) laser facility consists of eight high-power nanosecond laser beams and one shortpulse picosecond petawatt laser. It is designed for the study of inertial confinement fusion(ICF), especially for conducting fast ignition(FI) research in China and other basic science experiments. To perform FI successfully with hohlraum targets containing a golden cone, the long-pulse beam and cylindrical hohlraum as well as the short-pulse beam and cone target alignment must satisfy tight specifications(30 and 20 μm rms for each case). To explore new ICF ignition targets with six laser entrance holes(LEHs), a rotation sensor was adapted to meet the requirements of a three-dimensional target and correct beam alignment. In this paper, the strategy for aligning the nanosecond beam based on target alignment sensor(TAS) is introduced and improved to meet requirements of the picosecond lasers and the new six LEHs hohlraum targets in the SG-II-U facility. The expected performance of the alignment system is presented, and the alignment error is also discussed. | Lei Ren Ping Shao Dongfeng Zhao Yang Zhou Zhijian Cai Neng Hua Zhaoyang Jiao Lan Xia Zhanfeng Qiao Rong Wu Lailin Ji Dong Liu Lingjie Ju Wei Pan Qiang Li Qiang Ye Mingying Sun Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，1： | 2 |
| 16 | Ulinastatin reduces urinary sepsis?related inflammation by upregulatingIL?10 and downregulating TNF?α levels显示文摘 | Xian Chen Yi Wang Hongmei Luo Zhigang Luo Lisha Liu Wujun Xu Tao Zhang Ning Yang Xiangyang Long Neng Zhu Huang Xie Jun Liu | 2013 | Molecular Medicine Reports2013，，1： | 2 |
| 17 | An application of differential subordinations and some criteria for starlikeness 显示文摘 | Xu Neng Yang Dinggong | 2005 | Indian J Pure Appl Math2005，36，10： | 1 |
| 18 | Preliminary study on aerosol particle addition calibration method for on-line quantitative analysis of airborne radioactive particles with ICP-MS显示文摘 | Yong Yang Su Zhi Ming Li Hong Bo Dong Guo Qing Zhou Li Hua Zhai Jiang Xu Neng Bin Huang Shi Zeng Feng Rong Zhu | 2011 | International Journal of Environmental Analytical Chemistry2011，，5： | 1 |
| 19 | Fire retardant polyetherimide nanocomposites显示文摘 | Yang chuan Ke Cheng fen Long Zong neng Qi | 1999 | J Appl Polym Sci1999，7，1： | 1 |
| 20 | Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage显示文摘 | Na Zhao Chunjiu Zhong Yang Wang Yanling Zhao Neng Gong Guomin Zhou Tianle Xu Zhen Hong | 2007 | Neurobiology of Disease2007，，2： | 1 |
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