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| 1 | Tacrolimus and mycophenolate mofetil as second-line treatment in autoimmune hepatitis:Is the evidence of sufficient quality to develop recommendations?显示文摘BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement. | Mohammadreza Abdollahi Neda Khalilian Ekrami Morteza Ghojazadeh H Marike Boezen Mohammadhossein Somi Behrooz Z Alizadeh | 2020 | World Journal of Gastroenterology2020，26，38： | 5 |
| 2 | Evolution of the social network of scientific collaborations显示文摘 | Barabási A L Jeong H Neda Z | 2002 | Physica A2002，311，34： | 1 |
| 3 | Evolution of the social network of scientific collaborations显示文摘 | Barabási A L Jeong H Neda Z | 2002 | Physics A2002，3，11： | 1 |
| 4 | Computer simulation of the microstructure and rheology of semi-solid alloys under shear 显示文摘 | Perez M Barbe J C Neda Z | 2000 | Acta Mater2000，48，： | 1 |
| 5 | Evolution of the social network of scientific collaborations显示文摘 | Barabasi A L Jeonga H Neda Z | 2002 | Physica A2002，311，： | 1 |
| 6 | Evolution of the social network of scientific collaborations显示文摘 | Barabasi A L Jeong H Neda Z | 2002 | Physica A2002，311，34： | 1 |
| 7 | Physics of the rhythmic applause显示文摘 | NEDA Z | 2000 | Physical Review E2000，61，： | 1 |
| 8 | Evolution of the so-cial network of scientific collaborations 显示文摘 | Barabdsi A L Jeong H Neda Z | 2002 | Physica A:Statistical Mechanics and its Applications2002，311，34： | 1 |
| 9 | Evolution of the social network of scientific collaborations 显示文摘 | Albert - L6szl6 Barab6si Jeong H Neda Z | 2002 | Physica A -statistical Mechanics and Its Applications2002，311，34： | 1 |
| 10 | Evolution of the socialnetwork of scientific collaborations显示文摘 | Barabasi A-L Jeong H Neda Z Ravasz E Schubert A Vicsek T | 2002 | Physica A2002，311，： | 1 |
| 11 | Measuring preferential attachment in evolving networks显示文摘 | JEONG H NEDA Z BARABQCI A L | 2003 | EPL2003，61，4： | 1 |
| 12 | The sound of many hands clapping显示文摘 | NEDA Z RAVASZ E VISCEK T | 2000 | Nature2000，403，： | 1 |
| 13 | A rare case of bilateral ectopic pregnancy and differential diagnosis of gestational trophoblastic disease显示文摘 | Arab M Neda Kazemi S Vahedpoorfard Z | 2015 | J Reprod Infertil2015，16，1： | 1 |
| 14 | Computer simulation of the mierostrueture and rheology of semi-sol-id alloys under shear显示文摘 | Perer M Barbe J C Neda Z | 2000 | Acta Mater2000，48，14： | 1 |
| 15 | Evolution of the social network of scientific collaborations显示文摘 | Barabasi A -L Jeong H Neda Z | 2002 | Physica A2002，311，34： | 1 |
| 16 | Evolution of the social network of sicence collaborations显示文摘 | BARABASI A L JEONG H NEDA Z | 2002 | Physica A2002，311，： | 1 |
| 17 | Statistical Mechanics of Complex Networks 显示文摘 | BARABASI A-L JEONG H NEDA Z | 2002 | Physica A2002，311，： | 1 |
| 18 | Evolutionof the social network of scientific collaborations 显示文摘 | Barabasi A L Neda H J Z Ravasza E | 2002 | Physica A2002，311，34： | 1 |
| 19 | The sound of many hands clapping显示文摘 | NEDA Z RAVASZ E BRECHET Y | 2000 | Nature2000，403，： | 1 |
| 20 | Evolution Of the Social Network of Scientific Collaborations 显示文摘 | Barabasi A L Jeong H Neda Z | 2002 | Physica A: Statistical Mechanics and Its Applications2002，311，34： | 1 |
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