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| 1 | Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules显示文摘The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine.It is now accepted that the dysfunction of the sit diaphragm contributes to the development of proteinuria in several glomerular diseases.Nephrin,a gene product of NPHS1,a gene for a congenital nephrotic syndrome of Finnish type,constitutes an extracellular domain of the slit diaphragm.Podocin was identified as a gene product of NPHS2,a gene for a familial steroid-resistant nephrotic syndrome of French.Podocin binds the cytoplasmic domain of nephrin.After then,CD2 associated protein,NEPH1 and transient receptor potential-6 were also found as crucial molecules of the slit diaphragm.In order to explore other novel molecules contributing to the development of proteinuria,we performed a subtraction hybridization assay with a normal rat glomerular RNA and a glomerular RNA of rats with a puromycin aminonucleoside nephropathy,a mimic of a human minimal change type nephrotic syndrome.Then we have found that synaptic vesicle protein 2B,ephrin-B1 and neurexin were already downregulated at the early stage of puromycin amino-nucleoside nephropathy,and that these molecules were localized close to nephrin.It is conceivable that these molecules are the slit diaphragm associated molecules,which participate in the regulation of the barrier function.These molecules could be targets to establish a novel therapy for nephrotic syndrome. | Yoshiyasu Fukusumi Naoko Miyauchi Taeko Hashimoto Akira Saito Hiroshi Kawachi | 2014 | World Journal of Nephrology2014，3，3： | 9 |
| 2 | 对有静脉内的提高对比的 C 手臂的肝肿瘤的脱离边缘评价计算了断层摄影术显示文摘 AIM:To evaluate the feasibility of intravenous contrastenhanced C-arm computed tomography(CT) for assessing ablative areas and margins of liver tumors.METHODS:Twelve patients(5 men,7 women;mean age,69.5 years) who had liver tumors(8 hepatocellular carcinomas,4 metastatic liver tumors;mean size,16.3 mm;size range,8-20 mm) and who underwent percutaneous radiofrequency ablations(RFAs) with a flatdetector C-arm system were retrospectively reviewed.Intravenously enhanced C-arm CT and multidetector computed tomography(MDCT) images were obtained at the end of the RFA sessions and 3-7 d after RFA to evaluate the ablative areas and margins.The ablated areas and margins were measured using axial plane images acquired by both imaging techniques,with prior contrast-enhanced MDCT images as the reference.The sensitivity,specificity,and positive and negative predictive values of C-arm CT for detecting insufficient ablative margins(< 5 mm) were calculated.Statistical differences in the ablative areas and margins evaluated with both imaging techniques were compared using a paired t-test.RESULTS:All RFA procedures were technically successful.Of 48 total ablative margins,19(39.6%) and 20(41.6%) margins were found to be insufficient with C-arm CT and MDCT,respectively.Moreover,there were no significant differences between these 2 imaging techniques in the detection of these insufficient ablative margins.The sensitivity,specificity,and positive and negative predictive values for detecting insufficient margins by C-arm CT were 90.0%,96.4%,94.7% and 93.1%,respectively.The mean estimated ablative areas calculated from C-arm CT(462.5 ± 202.1 mm 2) and from MDCT(441.2 ± 212.5 mm 2) were not significantly different.The mean ablative margins evaluated by C-arm CT(6.4 ± 2.2 mm) and by MDCT(6.0 ± 2.4 mm) were also not significantly different.CONCLUSION:The efficacy of intravenous contrastenhanced C-arm CT in assessing the ablative areas and margins after RFA of liver tumors is nearly equivalent to that of MDCT. | Jin Iwazawa Shoichi Ohue Naoko Hashimoto Takashi Mitani | 2012 | World Journal of Radiology2012，4，3： | 2 |
| 3 | Strain Rate Imaging for Noninvasive Functional Quantification of the Left Atrium: Comparative Studies in Controls and Patients With Atrial Fibrillation显示文摘 | Yoshie Inaba Satoshi Yuda Naoko Kobayashi Akiyoshi Hashimoto Kikuya Uno Tomoaki Nakata Kazufumi Tsuchihashi Tetsuji Miura Nobuyuki Ura Kazuaki Shimamoto | 2005 | Journal of the American Society of Echocardiography2005，，7： | 2 |
| 4 | Epidermal cell kinetics of pig skin in vivo following UVB irradiation: Apoptosis induced by UVB is enhanced in hyperproliferative skin condition显示文摘 | Naoko Kawagishi Yoshio Hashimoto Hidetoshi Takahashi Akemi Ishida-Yamamoto Hajime Iizuka | 1998 | Journal of Dermatological Science1998，，1： | 1 |
| 5 | Fusion of intravenous contrast-enhanced C-arm CT and pretreatment imaging for ablation margin assessment of liver tumors: A preliminary study显示文摘 | Jin Iwazawa Naoko Hashimoto Takashi Mitani Shoichi Ohue | 2012 | Indian Journal of Radiology and Imaging2012，，4： | 1 |
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