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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 3 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 4 | Quantitative computed tomography analysis for stratifying the severity of Coronavirus Disease 2019显示文摘To examine the feasibility of using a computer tool for stratifying the severity of Coronavirus Disease 2019(COVID-19)based on computed tomography(CT)images.We retrospectively examined 44 confirmed COVID-19 cases.All cases were evaluated separately by radiologists(visually)and through an in-house computer software.The degree of lesions was visually scored by the radiologist,as follows,for each of the 5 lung lobes:0,no lesion present;1,<1/3 involvement;2,>1/3 and<2/3 involvement;and 3,>2/3 involvement.Lesion density was assessed based on the proportion of ground-glass opacity(GGO),consolidation and fibrosis of the lesions.The parameters obtained using the computer tool included lung volume(mL),lesion volume(mL),lesion percentage(%),and mean lesion density(HU)of the whole lung,right lung,left lung,and each lobe.The scores obtained by the radiologists and quantitative results generated by the computer software were tested for correlation.A Chi-square test was used to test the consistency of radiologist-and computer-derived lesion percentage in the right/left lung,upper/lower lobe,and each of the 5 lobes.The results showed a strong to moderate correlation between lesion percentage scores obtained by radiologists and the computer software(r ranged from 0.7679 to 0.8373,P<0.05),and a moderate correlation between the proportion of GGO and mean lesion density(r=-0.5894,P<0.05),and proportion of consolidation and mean lesion density(r=0.6282,P<0.05).Computer-aided quantification showed a statistical significant higher lesion percentage for lower lobes than that assessed by the radiologists(x^2=8.160,P=0.004).Our experiments demonstrated that the computer tool could reliably and accurately assess the severity and distribution of pneumonia on CT scans. | Cong Shen Nan Yu Shubo Cai Jie Zhou Jiexin Sheng Kang Liu Heping Zhou Youmin Guo Gang Niu | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 13 |
| 5 | Plant phenological responses to climate change on the Tibetan Plateau: research status and challenges显示文摘Phenology studies the cycle of events in nature that are initiated and driven by an annually recurring environment. Plant phenology is expected to be one of the most sensitive and easily observable natural indicators of climate change. On the Tibetan Plateau(TP), an accelerated warming since the mid-1980 s has resulted in signiicant environmental changes. hese new conditions are accompanied by phenological changes that are characterized by considerable spatiotemporal heterogeneity. Satellite remote sensing observed widespread advance in the start of the plant growing season across the plateau during the 1980 s and 1990 s but substantial delay over 2000–2011 in the southwest although it continued to advance in the northeast regions of the TP. Both observational studies and controlled experiments have revealed, to some extent, the positive role of higher preseason temperature and even more precipitation in advancing the leaf onset and irst lowering date of the TP. However, a number of rarely visited research issues that are essential for understanding the role of phenology in ecosystem responses and feedback processes to climate change remain to be solved. Our review recommends that addressing the following questions should be a high priority. How did other phenological events change, such as lowering and fruiting phenology? What are the inluences from environmental changes other than temperature and precipitation, including human activities such as grazing? What are the genetic and physiological bases of plants phenological responses?How does phenological change inluence ecosystem structure and function at diferent scales and feedback to the climate system? Investigating these research questions requires, irst of all, new data of the associated environmental variables, and consistent and reliable phenological observation using diferent methodologies(i.e. in situ observations and remote sensing). | Miaogen Shen Shilong Piao Tsechoe Dorji Qiang Liu Nan Cong Xiaoqiu Chen Shuai An Shiping Wang Tao Wang Gengxin Zhang | 2015 | National Science Review2015，2，4： | 13 |
| 6 | Ginsenoside Rg1 Attenuates Isoflurane-induced Caspase-3 Activation via Inhibiting Mitochondrial Dysfunction显示文摘Objective The inhalation anesthetic isoflurane has been shown to induce mitochondrial dysfunction and caspase activation, which may lead to learning and memory impairment. Ginsenoside Rg1 is reported to be neuroprotective. We therefore set out to determine whether ginsenoside Rg1 can attenuate isoflurane-induced caspase activation via inhibiting mitochondrial dysfunction. Methods We investigated the effects of ginsenoside Rg1 at concentrations of 12.5, 25, and 50 μmol/L and pretreatment times of 12 h and 24 h on isoflurane-induced caspase-3 activation in H4 na?ve and stably transfected H4 human neuroglioma cells that express full-length human amyloid precursor protein(APP)(H4-APP cells). For mitochondrial dysfunction, we assessed mitochondrial permeability transition pore(m PTP) and adenosine-5'-triphosphate(ATP) levels. We employed Western blot analysis, chemiluminescence, and flowcytometry. Results Here we show that pretreatment with 50 μmol/L ginsenoside Rg1 for 12 h attenuated isoflurane-induced caspase-3 activation and mitochondrial dysfunction in H4-APP cells, while pretreatment with 25 and 50 μmol/L ginsenoside Rg1 for 24 h attenuated isoflurane-induced caspase-3 activation and mitochondrial dysfunction in both H4 na?ve and H4-APP cells. Conclusion These data suggest that ginsenoside Rg1 may ameliorate isoflurane-induced caspase-3 activation by inhibiting mitochondrial dysfunction. Pending further studies, these findings might recommend the use of ginsenoside Rg1 in preventing and treating isoflurane-induced neurotoxicity. | MIAO Hui Hui ZHEN Yu DING Guan Nan HONG Fang Xiao XIE Zhong Cong TIAN Ming | 2015 | Biomedical and Environmental Sciences2015，28，2： | 9 |
| 7 | Electrically Programmable Terahertz Diatomic Metamolecules for Chiral Optical Control显示文摘Optical chirality is central to many industrial photonic technologies including enantiomer identifcation,ellipsometry-based tomography,and spin multiplexing in optical communications.However,a substantial chiral response requires a threedimensional constituent,thereby making the morphology highly complex to realize structural reconfguration.Moreover,an active reconfguration demands intense dosage of external stimuli that pose a major limitation for on-chip integration.Here,we report a low bias,electrically programmable synthetic chiral paradigm with a remarkable reconfguration among levorotatory,dextrorotatory,achiral,and racemic conformations.Te switchable optical activity induced by the chiral conformations enables a transmission-type duplex spatial light modulator for terahertz single pixel imaging.Te prototype delivers a new strategy towards reconfgurable stereoselective photonic applications and opens up avenues for on-chip programmable chiral devices with tremendous applications in biology,medicine,chemistry,and photonics. | Longqing Cong Prakash Pitchappa Nan Wang Ranjan Singh | 2019 | Research2019，，1： | 8 |
| 8 | Multimodel projections and uncertainties of net ecosystem production in China over the twenty-first century显示文摘Ecosystems in China have been absorbing anthropogenic CO2 over the last three decades. Here, we assess future carbon uptake in China using models from phase 5 of Coupled Model Intercomparison Project under four socio-economic scenarios. The average of China's carbon sink from 2006 to 2100 represented by multimodel mean net ecosystem production(NEP) is projected to increase(relative to averaged NEP from 1976 to 2005) in the range of 0.137 and 0.891 Pg C a-1across differentscenarios. Increases in NEP are driven by increases in net primary production exceeding increases in heterotrophic respiration, and future carbon sink is mainly attributed to areas located in eastern China. However, there exists a considerable model spread in the magnitude of carbon sink and model spread tends to be larger when future climate change becomes more intense. The model spread may result from intermodel discrepancy in the magnitude of CO2 fertilization effect on photosynthesis, soil carbon turnover time, presence of carbon-nitrogen cycle and interpretation of land-use changes. For better quantifying future carbon cycle, a research priority toward improving model representation of these processes is recommended. | Tao Wang Xin Lin Shushi Peng Nan Cong Shilong Piao | 2014 | Chinese Science Bulletin2014，59，34： | 7 |
| 9 | Milling Force Model for Aviation Aluminum Alloy: Academic Insight and Perspective Analysis显示文摘Aluminum alloy is the main structural material of aircraft,launch vehicle,spaceship,and space station and is processed by milling.However,tool wear and vibration are the bottlenecks in the milling process of aviation aluminum alloy.The machining accuracy and surface quality of aluminum alloy milling depend on the cutting parameters,material mechanical properties,machine tools,and other parameters.In particular,milling force is the crucial factor to determine material removal and workpiece surface integrity.However,establishing the prediction model of milling force is important and difficult because milling force is the result of multiparameter coupling of process system.The research progress of cutting force model is reviewed from three modeling methods:empirical model,finite element simulation,and instantaneous milling force model.The problems of cutting force modeling are also determined.In view of these problems,the future work direction is proposed in the following four aspects:(1)high-speed milling is adopted for the thin-walled structure of large aviation with large cutting depth,which easily produces high residual stress.The residual stress should be analyzed under this particular condition.(2)Multiple factors(e.g.,eccentric swing milling parameters,lubrication conditions,tools,tool and workpiece deformation,and size effect)should be considered comprehensively when modeling instantaneous milling forces,especially for micro milling and complex surface machining.(3)The database of milling force model,including the corresponding workpiece materials,working condition,cutting tools(geometric figures and coatings),and other parameters,should be established.(4)The effect of chatter on the prediction accuracy of milling force cannot be ignored in thin-walled workpiece milling.(5)The cutting force of aviation aluminum alloy milling under the condition of minimum quantity lubrication(mql)and nanofluid mql should be predicted. | Zhenjing Duan Changhe Li Wenfeng Ding Yanbin Zhang Min Yang Teng Gao Huajun Cao Xuefeng Xu Dazhong Wang Cong Mao Hao Nan Li Gupta Munish Kumar Zafar Said Sujan Debnath Muhammad Jamil Hafiz Muhammad Ali | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 7 |
| 10 | Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells显示文摘Surgery is essential for controlling the symptoms and complications of stage IV breast cancer.However,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral metastasis.As a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been reported.Using two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival.NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were activated.Depletion experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging survival.Then,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine profiles.Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis.In addition,MWA of human breast cancer stimulated an autologous NK-cell response.These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis.MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing. | Muxin Yu Hong Pan Nan Che Li Li Cong Wang Yue Wang Ge Ma Mengjia Qian Jiawei Liu Mingjie Zheng Hui Xie Lijun Ling Yi Zhao Xiaoxiang Guan Qiang Ding Wenbin Zhou Shui Wang | 2021 | Cellular & Molecular Immunology2021，18，9： | 5 |
| 11 | Nano-enhanced biolubricant in sustainable manufacturing:From processability to mechanisms显示文摘To eliminate the negative effect of traditional metal-working fluids and achieve sustainable manufacturing,the usage of nano-enhanced biolubricant(NEBL)is widely researched in minimum quantify lubrication(MQL)machining.It's improved tool wear and surface integrity have been preliminarily verified by experimental studies.The previous review papers also concluded the major influencing factors of processability including nano-enhancer and lubricant types,NEBL concentration,micro droplet size,and so on.Nevertheless,the complex action of NEBL,from preparation,atomization,infiltration to heat transfer and anti-friction,is indistinct which limits preparation of process specifications and popularity in factories.Especially in the complex machining process,in-depth understanding is difficult and meaningful.To fll this gap,this paper concentrates on the comprehensive quantitative assessment of processability based on tribological,thermal,and machined surface quality aspects for NEBL application in turning,milling,and grinding.Then it attempts to answer mechanisms systematically considering multi-factor influence of molecular structure,physicochemical properties,concentration,and dispersion.Firstly,this paper reveals advanced lubrication and heat transfer mechanisms of NEBL by quantitative comparison with biolubricant-based MQL machining.Secondly,the distinctive filmformation,atomization,and infiltration mechanisms of NEBL,as distinguished from metal-working fluid,are clarified combining with its unique molecular structure and physical properties.Furtherly,the process optimization strategy is concluded based on the synergistic relationship analysis among process variables,physicochemical properties,machining mechanisms,and performance of NEBL.Finally,the future development directions are put forward aiming at current performance limitations of NEBL,which requires improvement on preparation and jet methods respects.This paper will help scientists deeply understand effective mechanism,formulate process specifications,and find future development trend of this technology. | Yanbin ZHANG Hao Nan LI Changhe LI Chuanzhen HUANG Hafiz Muhammad ALI Xuefeng XU Cong MAO Wenfeng DING Xin CUI Min YANG Tianbiao YU Muhammad JAMIL Munish Kumar GUPTA Dongzhou JIA Zafar SAID | 2022 | Friction2022，10，6： | 5 |
| 12 | Spatial variations in responses of vegetation autumn phenology to climate change on the tibetan Plateau显示文摘Aims Information about changes in the start and end of the vegetation growing season(SOS and EOS)is crucial for assessing ecosystem responses to climate change because of the high sensitivity of both to climate and their extensive influence on ecological processes in temperate and cold regions.climatic warming substantially advanced SOS on the tibetan Plateau from 1982 to 2011.However,it is unclear why EOS showed little delay despite increasing tem-perature over this period.Methods We used multiple methods to determine EOS from the satellite-observed normalized-difference vegetation index and investigated the relationships between EOS and its potential drivers on the tibetan Plateau over 1982-2011.Important findings We found a slight but non-significant delay in regionally averaged EOS of 0.7 day decade−1(P=0.18)and a widespread but weak delaying trend across the Plateau over this period.the inter-annual variations in regionally averaged EOS were driven mainly by pre-season temperature(partial R=0.62,P<0.01),and precipitation and insolation showed weak impact on EOS(P>0.10).Pre-season warming delayed EOS mainly in the eastern half and north-western area of the plateau.In the south-west,EOS was significantly and positively related to SOS,suggesting potentially indirect effects of winter weather conditions on the following autumn’s phenology through regulation of spring phenology.EOS was more strongly related with pre-season temperature in colder and wetter areas,reflecting vegetation adaptation to local climate.Interestingly,pre-season temperature had weaker delaying effects on EOS for vegeta-tion with a shorter growing season,for which SOS had a stronger control on inter-annual variations in EOS than for vegetation with a longer growing season.this indicates that shorter-season tibetan Plateau vegetation may have lower plasticity in adjusting the length of its growing season,whenever it begins,and that climate change is more likely to shift the growing season than extend it for that vegetation. | Nan Cong Miaogen Shen Shilong Piao | 2017 | Journal of Plant Ecology2017，10，5： | 4 |
| 13 | Fungus induces the release of IL- 8 in human corneal epithelial cells, via Dectin-1-mediated protein kinase C pathways显示文摘AIM: To identify whether Aspergillus fumigatus(A.fumigatus) hyphae antigens induced the release of interleukin-8(IL-8) in anti-fungal innate immunity of cultured human corneal epithelial cells(HCECs) and determine the involvement of intracellular signalling pathways. METHODS: HCECs were treated with A. fumigatus hyphae antigens with different concentrations and time.The cytoplasmic calcium of HCECs were assessed by fluorescence imaging. Western blot was used to detect the expression of Ca2 +-dependent protein kinase C(PKC). The IL-8 levels were determined by specific human IL-8 enzyme-linked immunosorbent assay(ELISA) and reverse transcriptase polymerase chain reaction(RT-PCR). Using a series of pharmacological inhibitors, we examined the upstream signalling pathway responsible for IL-8 expression in response to A.fumigatus hyphae antigens. RESULTS: Cells exposed to A. fumigatus hyphae antigens showed higher level of IL-8 m RNA expression and protein production. We demonstrated here that stimulation of HCECs with A. fumigatus hyphae triggers an intracellular Ca2 +flux and results in the activation of Ca2 +-dependent PKC(α, βⅠ and βⅡ) which can be attenuated by pre-treatment of cells with laminarin,suggesting that Dectin-1 signals pathway induced cytoplasmic calcium and influence the activation of PKC in HCECs. Inhibitors of Ca2 +-dependent PKC(Ro-31-8220 and Go6976) significantly abolished hyphae-induced expression of IL-8.CONCLUSION: Our findings suggest that A. fumigatushyphae-induced IL-8 expression was regulated by the activation of Dectin-1-mediated Ca2 +-dependent PKC in HCECs. | Xu-Dong Peng Gui-Qiu Zhao Jing Lin Nan Jiang Qiang Xu Cheng-Cheng Zhu Jian-Qiu Qu Lin Cong Hui Li | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 4 |
| 14 | Seg-CapNet:A Capsule-Based Neural Network for the Segmentation of Left Ventricle from Cardiac Magnetic Resonance Imaging显示文摘Deep neural networks(DNNs)have been extensively studied in medical image segmentation.However,existing DNNs often need to train shape models for each object to be segmented,which may yield results that violate cardiac anatomical structure when segmenting cardiac magnetic resonance imaging(MRI).In this paper,we propose a capsulebased neural network,named Seg-CapNet,to model multiple regions simultaneously within a single training process.The Seg-CapNet model consists of the encoder and the decoder.The encoder transforms the input image into feature vectors that represent objects to be segmented by convolutional layers,capsule layers,and fully-connected layers.And the decoder transforms the feature vectors into segmentation masks by up-sampling.Feature maps of each down-sampling layer in the encoder are connected to the corresponding up-sampling layers,which are conducive to the backpropagation of the model.The output vectors of Seg-CapNet contain low-level image features such as grayscale and texture,as well as semantic features including the position and size of the objects,which is beneficial for improving the segmentation accuracy.The proposed model is validated on the open dataset of the Automated Cardiac Diagnosis Challenge 2017(ACDC 2017)and the Sunnybrook Cardiac Magnetic Resonance Imaging(MRI)segmentation challenge.Experimental results show that the mean Dice coefficient of Seg-CapNet is increased by 4.7%and the average Hausdorff distance is reduced by 22%.The proposed model also reduces the model parameters and improves the training speed while obtaining the accurate segmentation of multiple regions. | Yang-Jie Cao Shuang Wu Chang Liu Nan Lin Yuan Wang Cong Yang Jie Li | 2021 | Journal of Computer Science & Technology2021，36，2： | 3 |
| 15 | Tracing of dye molecules in living plants through NaGdF_4:Yb^(3+),Er^(3+)fluorescent nanoprobes显示文摘In this paper, we demonstrated trace of dye molecules in living plants. The NaGdF4:Yb^(3+),Er^(3+) nanoparticles probe was used to detect the rhodamine B(RhB) in bean sprout. It is found that the fluorescencedye can be efficiently imbibed during the growing process and the absorbance presented a position dependence effect, which was supported by the upconversion spectra and the fluorescent image characterization. In addition, the concentration of the residual RhB in bean sprout can be efficiently traced by the synthesized probe based on the fluorescent resonant energy transfer. Finally, the relation between the excitation power, concentration and the ratio of yellow to green emission are discussed in detail. These results can be helpful in understanding the RhB dye molecules absorbance process in vegetable growth and provide an efficient way to trace the residual dyes in vivo plant. | Xiaofeng Wu Ya'nan Zhang Shiping Zhan Jin Li Guozheng Nie Shigang Hu Cong Yan Shaobing Wu Shengbin Cheng Junshan Hu Lichun Shi Yunxin Liu | 2019 | Journal of Rare Earths2019，37，3： | 3 |
| 16 | Minimum quantity lubrication machining of aeronautical materials using carbon group nanolubricant: From mechanisms to application显示文摘It is an inevitable trend of sustainable manufacturing to replace flood and dry machining with minimum quantity lubrication(MQL)technology.Nevertheless,for aeronautical difficult-tomachine materials,MQL couldn’t meet the high demand of cooling and lubrication due to high heat generation during machining.Nano-biolubricants,especially non-toxic carbon group nano-enhancers(CGNs)are used,can solve this technical bottleneck.However,the machining mechanisms under lubrication of CGNs are unclear at complex interface between tool and workpiece,which characterized by high temperature,pressure,and speed,limited its application in factories and necessitates in-depth understanding.To fill this gap,this study concentrates on the comprehensive quantitative assessment of tribological characteristics based on force,tool wear,chip,and surface integrity in titanium alloy and nickel alloy machining and attempts to answer mechanisms systematically.First,to establish evaluation standard,the cutting mechanisms and performance improvement behavior covering antifriction,antiwear,tool failure,material removal,and surface formation of MQL were revealed.Second,the unique film formation and lubrication behaviors of CGNs in MQL turning,milling,and grinding are concluded.The influence law of molecular structure and micromorphology of CGNs was also answered and optimized options were recommended by considering diverse boundary conditions.Finally,in view of CGNs limitations in MQL,the future development direction is proposed,which needs to be improved in thermal stability of lubricant,activity of CGNs,controllable atomization and transportation methods,and intelligent formation of processing technology solutions. | Xin CUI Changhe LI Wenfeng Ding Yun CHEN Cong MAO Xuefeng XU Bo LIU Dazhong WANG Hao Nan LI Yanbin ZHANG Zafar SAID Sujan DEBNATH Muhammad JAMIL Hafiz Muhammad ALI Shubham SHARMA | 2022 | Chinese Journal of Aeronautics2022，35，11： | 3 |
| 17 | Adjuvant Effects of Dual Co-stimulatory Molecules on Cellular Responses to HIV Multiple-epitope DNA Vaccination显示文摘Designing adjuvants that can induce strong cytotoxic T cell responses is largely required for preparing DNA vaccines. In this study we explored dual costimulatory molecules 4-1BBL and OX40L as adjuvants to improve the efficiency of the HIV multiple-epitope DNA vaccine. When explored in the human dendritic cell-T cell based coculture system,dual costimulatory molecules significantly enhanced the anti-HIV T cell response of the HIV mul-tiple-epitope DNA vaccine,as detected by intracellular cytokine staining to HIV antigens,cytokines accumulation in the cultures,and antigen-specific cytotoxic T lymphocyte responses. These results suggest that dual costimulatory molecules 4-1BBL and OX40L can effectively increase the potential of the HIV multiple-epitope antigen DNA vaccine and may provide an exciting approach for HIV therapy. | SHEN Zhen-wei JIN Hong-tao LI Chang CONG Yan-zhao NAN Wen-long BAI Liang JIN Ning-yi | 2009 | Chemical Research in Chinese Universities2009，25，3： | 2 |
| 18 | Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment显示文摘Decades have passed since the first nanoparticles-base medicine was approved for human cancer treatment, and the research and development of nanoparticles for drug delivery are always undergoing.Nowadays, the significant advances complicate nanoparticles’ branches, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines and nano-antibodies, etc. These nanoparticles show numerous capabilities in treatment and diagnosis of stubborn diseases like cancer and neurodegenerative diseases, emerging as novel drug carriers or therapeutic agents in future. In this review, the complicated branches of nanoparticles are classified and summarized, with their property and functions concluded. Besides, there are also some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review. Except these excellent works in newly-produced drug delivery nanoparticles, some points of view and future expectations are made in the end. | Rui Liu Cong Luo Zhiqing Pang Jinming Zhang Shaobo Ruan Meiying Wu Lei Wang Tao Sun Nan Li Liang Han Jinjin Shi Yuanyu Huang Weisheng Guo Shaojun Peng Wenhu Zhou Huile Gao | 2023 | Chinese Chemical Letters2023，34，2： | 2 |
| 19 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 20 | Preparation of Polyporus Albicans Teng Sulfate andIts Anti-coagulation Activity显示文摘More studies have indicated that polysaccharide sulfate has anti-coagulant activity.Now,heparin is the most popular anticoagulant used in clinic,however,its side effects have also caused highly concern.It is still under intensive investigations to synthesize effective safe polysaccharide sulfate as heparin substitute.We extracted water-soluble polysaccharide from fermented mycelium of edible polyporus albicans(Imaz.) teng,and got the water-soluble polyporus albicans teng sulfate(PATS) by modifying the water-solubility polyose with the method of chlorosulfonic acid-pyridine.The anti-coagulant assay of PATS in vitro towards normal human plasma indicates its remarkable anticoagulant activity,while the dose could be as low as 5 mg/L for anticoagulation.The anti-coagulant effect was equivalent to that of heparin about 150 U when the concentration of PATS was 10 mg/L.The study on anti-coagulation mechanism suggests that PATS got involved in the intrinsic pathway.The anti-coagulation activity of PATS was due to the inhibition of the coagulation factors IIa and Xa activities mediated by antithrombin Ⅲ(ATIII).The anti-coagulation mechanism of PATS is absolutely identical to that of heparin.In conclusion,we suggest that PATS has the similar anti-coagulation characteristic to heparin,but with a better anti-coagulation effect.Meanwhile,derived from edible fungus-polysaccharide,PATS has more bio-safety advantage.Therefore,PATS has promising future to be developed and used as an ideal substitute for heparin in clinic. | YANG Xi-ming FAN Cong GUO Nan YAO Xing-wei ZHANG Li-ping | 2010 | Chemical Research in Chinese Universities2010，26，6： | 2 |
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