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| 1 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 2 | Modeling on mechanical behavior and damage evolution of single-lap bolted composite interference-fit joints under thermal effects显示文摘This paper reports the modeling method and outcomes of mechanical performance and damage evolution of single-lap bolted composite interference-fit joints under extreme temperatures.The anisotropic continuum damage model involving thermal effects is established on continuum damage mechanics which integrates the shear nonlinearity constitutive relations characterized by Romberg-Osgood equation.The temperature-induced modification of thermal strains and material properties is incorporated in stress-strain analysis,extended 3 D failure criteria and exponential damage evolution rules.The proposed model is calibrated and employed to simulate behavior of composite joints in interference fitting,bolt preloading,thermal and bearing loading processes,during which the influence of interference-fit sizes,preload levels,laminate layups and service temperatures is thoroughly investigated.The predicated interfacial behavior,bearing response and failure modes are in good agreement with experimental tests.The numerical model is even capable of reflecting some non-intuitive experimental findings such as residual stress relaxation and matrix softening at elevated temperatures. | Junshan HU Kaifu ZHANG Hui CHENG Peng ZOU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 3 |
| 3 | Tracing of dye molecules in living plants through NaGdF_4:Yb^(3+),Er^(3+)fluorescent nanoprobes显示文摘In this paper, we demonstrated trace of dye molecules in living plants. The NaGdF4:Yb^(3+),Er^(3+) nanoparticles probe was used to detect the rhodamine B(RhB) in bean sprout. It is found that the fluorescencedye can be efficiently imbibed during the growing process and the absorbance presented a position dependence effect, which was supported by the upconversion spectra and the fluorescent image characterization. In addition, the concentration of the residual RhB in bean sprout can be efficiently traced by the synthesized probe based on the fluorescent resonant energy transfer. Finally, the relation between the excitation power, concentration and the ratio of yellow to green emission are discussed in detail. These results can be helpful in understanding the RhB dye molecules absorbance process in vegetable growth and provide an efficient way to trace the residual dyes in vivo plant. | Xiaofeng Wu Ya'nan Zhang Shiping Zhan Jin Li Guozheng Nie Shigang Hu Cong Yan Shaobing Wu Shengbin Cheng Junshan Hu Lichun Shi Yunxin Liu | 2019 | Journal of Rare Earths2019，37，3： | 3 |
| 4 | Stress analysis and damage evolution in individual plies of notched composite laminates subjected to in-plane loads显示文摘This work aims to investigate local stress distribution, damage evolution and failure of notched composite laminates under in-plane loads. An analytic method containing uniformed boundary equations using a complex variable approach is developed to present layer-by-layer stresses around the notch. The uniformed boundary equations established in series together with conformal mapping functions are capable of dealing with irregular boundary issues around the notch and at infinity. Stress results are employed to evaluate the damage initiation and propagation of notched composites by progressive damage analysis(PDA). A user-defined subroutine is developed in the finite element(FE) model based on coupling theories for mixed failure criteria and damage mechanics to efficiently investigate damage evolution as well as failure modes. Carbon/epoxy laminates with a stacking sequence of [45°/0°/ 60°/90°]sare used to investigate surface strains, in-plane load capacity and microstructure of failure zones to provide analytic and FE methods with strong validation. Good agreement is observed between the analytic method, the FE model and experiments in terms of the stress(strain) distributions, damage evaluation and ultimate strength, and the layerby-layer stress components vary according to a combination effect of fiber orientation and loading type, causing diverse failure modes in individuals. | Hu Junshan Zhang Kaifu Cheng Hui Liu Ping Zou Peng Song Danlong | 2017 | Chinese Journal of Aeronautics2017，30，1： | 2 |
| 5 | A novel virtual material layer model for predicting natural frequencies of composite bolted joints显示文摘A novel virtual material layer model based on the fractal theory was proposed to predict the natural frequencies of carbon fiber reinforced plastic composite bolted joints.Rough contact surfaces of composite bolted joints are modeled with this new proposed approach.Numerical and experimental modal analyses were conducted to validate the effectiveness of the proposed model.A good consistence is noted between the numerical and experimental results.To demonstrate the necessity of accurately modeling the rough contact surfaces in the prediction of natural frequencies,virtual material layer model was compared with the widely used traditional model based on the Master-Slave contact algorithm and experiments,respectively.Results show that the proposed model has a better agreement with experiments than the widely used traditional model(the prediction accuracy is raised by 8.77%when the pre-tightening torque is 0.5 N·m).Real contact area ratio A*of three different virtual material layers were calculated.Value of A*were discussed with dimensionless load P*,fractal dimension D and fractal roughness G.This work provides a new efficient way for accurately modeling the rough contact surfaces and predicting the natural frequencies of composite bolted joints,which can be used to help engineers in the dynamic design of composite materials. | Yu YANG Hui CHENG Biao LIANG Di ZHAO Junshan HU Kaifu ZHANG | 2021 | Chinese Journal of Aeronautics2021，34，8： | 1 |
| 6 | Variable Stiffness Identification and Configuration Optimization of Industrial Robots for Machining Tasks显示文摘Industrial robots are increasingly being used in machining tasks because of their high flexibility and intelligence.However,the low structural stiffness of a robot significantly affects its positional accuracy and the machining quality of its operation equipment.Studying robot stiffness characteristics and optimization methods is an effective method of improving the stiffness performance of a robot.Accordingly,aiming at the poor accuracy of stiffness modeling caused by approximating the stiffness of each joint as a constant,a variable stiffness identification method is proposed based on space gridding.Subsequently,a task-oriented axial stiffness evaluation index is proposed to quantitatively assess the stiffness performance in the machining direction.In addition,by analyzing the redundant kinematic characteristics of the robot machining system,a configuration optimization method is further developed to maximize the index.For numerous points or trajectory-processing tasks,a configuration smoothing strategy is proposed to rapidly acquire optimized configurations.Finally,experiments on a KR500 robot were conducted to verify the feasibility and validity of the proposed stiffness identification and configuration optimization methods. | Jiachen Jiao Wei Tian Lin Zhang Bo Li Junshan Hu Yufei Li Dawei Li Jianlong Zhang | 2022 | Chinese Journal of Mechanical Engineering2022，35，5： | 1 |
| 7 | MIMO Ad Hoe networks: Medium access control, saturation throughput and optimal hop distance 显示文摘 | HU MING ZHANG JUNSHAN | 2004 | Journal of Communications and Networks2004，6，4： | 1 |
| 8 | Sacrificial layer-assisted nanoscale transfer printing显示文摘Transfer printing is an emerging assembly technique for flexible and stretchable electronics.Although a variety of transfer printing methods have been developed,transferring patterns with nanometer resolution remains challenging.We report a sacrificial layer-assisted nanoscale transfer printing method.A sacrificial layer is deposited on a donor substrate,and ink is prepared on and transferred with the sacrificial layer.Introducing the sacrificial layer into the transfer printing process eliminates the effect of the contact area on the energy release rate(ERR)and ensures that the ERR for the stamp/ink-sacrificial layer interface is greater than that for the sacrificial layer/donor interface even at a slow peel speed(5mm s−1).Hence,large-area nanoscale patterns can be successfully transferred with a yield of 100%,such as Au nanoline arrays(100 nm thick,4 mm long and 47 nm wide)fabricated by photolithography techniques and PZT nanowires(10mm long and 63nm wide)fabricated by electrohydrodynamic jet printing,using only a blank stamp and without the assistance of any interfacial chemistries.Moreover,the presence of the sacrificial layer also enables the ink to move close to the mechanical neutral plane of the multilayer peel-off sheet,remarkably decreasing the bending stress and obviating cracks or fractures in the ink during transfer printing. | Junshan Liu Bo Pang Riye Xue Rui Li Jinlong Song Xiaojun Zhao Dazhi Wang Xiaoguang Hu Yao Lu Liding Wang | 2020 | Microsystems & Nanoengineering2020，6，1： | 0 |
| 9 | Hierarchical assembly of uranyl metallacycles involving macrocyclic hosts显示文摘Actinide metallacycles are an emerging class of functional coordination assemblies,but multi-level assembly from metallacycle units toward hierarchical supramolecular structures are still rarely investigated.In this work,we put forward a novel supramolecular inclusion-based method through introducing two macrocyclic hosts,cucurbit[7]uril(CB[7])and cucurbit[8]uril(CB[8])to facilitate hierarchical assembly of uranyl metallacycles with higher complexity,and successfully prepare two different kinds of uranyl metallacycle-based complexes with intriguing hierarchical structures,a CB[7]-based four-member molecular necklace([4]MN)and a CB[8]-involved ring-in-ring supramolecular polymer chain.The results obtained here prove the feasibility of supramolecular inclusion for regulating coordination assembly of uranyl metallacycles and related hierarchical structures.It is believed that this method can be used to achieve the construction of actinide coordination assemblies with higher structural complexity. | Yuanyuan Liang Lei Mei Qiuyan Jin Junshan Geng Jingyang Wang Kang Liu Kongqiu Hu Jipan Yu Weiqun Shi | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 10 | Toward understanding the cross-linking from molecular chains to aggregates by engineering terminals of supramolecular hyperbranched polysiloxane显示文摘Crosslinking thermosets with hyperbranched polymers confers them superior comprehensive performance.However,it still remains a further understanding of polymer crosslinking from the molecular chains to the role of aggregates.In this study,three hyperbranched polysiloxane structures(HBPSi-R)are synthesized as model macromolecules,each featuring distinct terminal groups(R denotes amino,epoxy,and vinyl groups)while similar molecular backbone(Si-O-C).These structures were subsequently copolymerized with epoxy monomers to construct interpenetrating HBPSi-R/epoxy/anhydride co-polymer systems.The spatial molecular configuration and flexible Si-O-C branches of HBPSi-R endow them with remarkable reinforcement and toughening effects.Notably,an optimum impact strength of 28.9 kJ mol^(−1) is achieved with a mere 3%loading of HBPSi-V,nearly three times that of the native epoxy(12.9 kJ mol^(−1)).By contrasting the terminal effects,the aggregation states and crosslinking modes were proposed,thus clarifying the supramolecular-dominant aggregation mechanism and covalent-dominant dispersion mechanism,which influences the resulting material properties.This work underscores the significance of aggregate science in comprehending polymer crosslinking and provides theoretical insights for tailoring material properties at a refined molecular level in the field of polymer science. | Yuanbo Zhang Junshan Yuan Jingzhi Hu Zhixuan Tian Weixu Feng Hongxia Yan | 2024 | Aggregate2024，5，1： | 0 |
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