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| 1 | Liver transplantation for viral hepatitis in 2015显示文摘Liver transplantation(LT) is a life-saving treatment forpatients with end-stage liver disease and for patients with liver cell cancer related to liver disease. Acute and chronic liver diseases related to hepatitis viruses are between the main indications for liver transplantation. The risk of viral reinfection after transplantation is the main limiting factor in these indications. Before the availability of antiviral prophylaxis, hepatitis B virus(HBV) recurrence was universal in patients who were HBV DNA-positive before transplantation. The natural history of recurrent HBV was accelerated by immunosuppression, and it progressed rapidly to graft failure and death. Introduction of post-transplant prophylaxis with immunoglobulin alone first, and associated to antiviral drugs later, drastically reduced HBV recurrence, resulting in excellent long-term outcomes. On the contrary, recurrence of hepatitis C is the main cause of graft loss in most transplant programs. Overall, patient and graft survival after LT for hepatitis C virus(HCV)-associated cirrhosis is inferior compared with other indications. However, successful pretransplant or post transplant antiviral therapy has been associated with increased graft and overall survival. Until recently, the combination of pegylated interferon and ribavirin was the standard of care for the treatment of patients with chronic hepatitis C. Highly active antiviral compounds have been developed over the past decade, thanks to new in vitro systems to study HCV entry, replication, assembly, and release. | alberto ferrarese alberto zanetto martina gambato ilaria bortoluzzi elena nadal giacomo germani marco senzolo patrizia burra francesco paolo russo | 2016 | World Journal of Gastroenterology2016，22，4： | 7 |
| 2 | Emerging pollutants in the environment:A challenge for water resource management显示文摘A significant number of emerging pollutants(EPs)resulting from point and diffuse pollution is present in the aquatic environment.These are chemicals that are not commonly monitored but have the potential to enter the environment and cause adverse ecological and human health effects.According to the NORMAN network,at least 700 substances categorized into 20 classes,have been identified in the European aquatic environment.In light of their potential impact action is urgently required.In this study,we present a concept that shows the current state of art and challenges for monitoring programs,fate and risk assessment tools and requirements for policies with respect to emerging pollutants as a base for sustainable water resource management.Currently,methods for sampling and analysis are not harmonized,being typically focused on certain EP classes.For a number of known highly hazardous EPs detection limits are too high to allow proper risk assessment.For other EPs such as microplastics method development is in its infancy.Advanced ultra-sensitive instrumental techniques should be used for quantitative determination of prioritized EPs in water,suspended matter,soil and biota.Data on EPs'and their metabolites'properties that determine their fate in the environment are often not available.National surveys on water quality often use different parameters for water quality assessment and often do not include EPs.A harmonized monitoring of surface and groundwater is not yet achieved and urgently required.Specific component integrated into models assessing the fate of EPs in a multi compartment environmental approach are missing and must be developed.The main goal of risk assessment is the overall protection of ecological communities in the aquatic environment and human health.New methods for assessing the cumulative risks from combined exposures to several stressors,including mixtures of EPs in a multi-scale approach are required.A combination of regulations and management measures with respect to use/emissions of EPs into the environment,as well as to their occurrence in the environment are fundamental to reach an efficient water resource management. | Violette Geissen Hans Mol Erwin Klumpp Günter Umlauf Marti Nadal Martine van der Ploeg Sjoerd E.A.T.M.van de Zee Coen J.Ritsema | 2015 | International Soil and Water Conservation Research2015，3，1： | 3 |
| 3 | Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation显示文摘 | Alexandre Calon Elisa Espinet Sergio Palomo-Ponce Daniele V.F. Tauriello Mar Iglesias María Virtudes Céspedes Marta Sevillano Cristina Nadal Peter Jung Xiang H.-F. Zhang Daniel Byrom Antoni Riera David Rossell Ramón Mangues Joan Massagué Elena Sancho Edua | 2012 | Cancer Cell2012，，5： | 2 |
| 4 | Differential MRI diagnosis between brain abscesses and necrotic or cystic brain tumors using the apparent diffusion coefficient and normalized diffusion weighted images 显示文摘 | Nadal DL Herlidou S | 2003 | Magn R eson Imaging2003，21，6： | 1 |
| 5 | CD133 expression in circulating tumor cells from breast cancer patients:potential role in resistance to chemotherapy显示文摘 | Nadal R Ortega FG Salido M | 2013 | Int J Cancer2013，133，10： | 1 |
| 6 | Neuropathic pain is enhanced in delta-opioid receptor knockout mice显示文摘 | NADAL X BANOS JE KIEFFER BL | 2006 | Eur J Neurosci2006，23，3： | 1 |
| 7 | Interlaboratory transfer of a real-time polymerase chain reactionassay for quantitative detection of genetically modifiedmaize event TC-1507显示文摘 | La Paz J L Garcia-Muniz N Nadal A | 2006 | Journal of AOAC International2006，89，5： | 1 |
| 8 | Rapid detection of Mycoplasma pneumoniae in clinical samples by real-time PCR显示文摘 | Hardegger D Nadal D Bossart W | 2000 | J Microbiol Methods2000，41，1： | 1 |
| 9 | Molecular biology of laryngeal squamous cell carcinoma显示文摘 | Nadal A Cardesa A | 2003 | Virchows Arch2003，442，1： | 1 |
| 10 | Interlaboratory transfer of a real-time polymerase chain reaction assay for quantitative detection of genetically modifiedmaize event TC-1507显示文摘 | La Paz J L Garcia-Muniz N Nadal A | 2006 | Journal of AOAC International2006，89，5： | 1 |
| 11 | The role of the pancreatic endocannabinoid system in glucose metabolism显示文摘 | Bermudez-Silva FJ Perez JS Nadal A | 2009 | Best Pra Res Clin Endoc Met2009，23，1： | 1 |
| 12 | Metal concentrations in surface water and sediments from Pardo River,Brazil:human health risks显示文摘 | Alves RI Sampaio CF Nadal M | 2014 | Environ Res2014，133，： | 1 |
| 13 | Intracerebral synthesis of tumor necrosis factor alpha and interleukin 2 in infec- tious meningitis显示文摘 | Frei K Nadal D Fontana A | 1990 | Ann N YAcad Sci1990，594，： | 1 |
| 14 | Intracerebral synthesis of tumor necrosis factor alpha and interleukin 6 in infec- tious meningitis 显示文摘 | Frei K Nadal D Fontana A | 1990 | Ann N YAcad Sci1990，594，： | 1 |
| 15 | Functional and physical interac- tions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A 显示文摘 | MAO Z NADAL GINARD B | 1996 | J Biol Chem1996，271，14： | 1 |
| 16 | Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway显示文摘 | BonniA SunY Nadal - Vicens M | 1997 | Science1997，278，5337： | 1 |
| 17 | Perseverance of exploration in novel environments predicts morphine place conditioning in rats显示文摘 | Nadal R Rotllant D Marquez C | 2005 | Behav Brain Res2005，165，： | 1 |
| 18 | Levels of PAHsin Soil and Vegetation Samples From Tarragona County,Spain显示文摘 | NADAL M SCHUHMACHER M DOMINGO J L | 2004 | Environmental Pollution2004，132，1： | 1 |
| 19 | Model of the aerodynamic behavior of a pararotor显示文摘 | Vicente Nadal Mora angel Sanz-Andres alvaro Cuerva | 2006 | Journal of Aircraft2006，43，6： | 1 |
| 20 | Short-term natural weathering of MSWI bottom ash显示文摘 | Fernandez A I Nadal R | 2000 | Journal of Hazardous Materials2000，79，3： | 1 |
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