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| 1 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 2 | intrahepatic cholangiocarcinoma 的胰腺的复发: 案例报告和文学的评论显示文摘 Intrahepatic cholangiocarcinomas(ICC)are malignant tumors arising from the intrahepatic bile ducts that frequently recur after resection.The main sites of recurrence are the remnant liver,lymph nodes and lungs.Metastasis to the pancreas has never been reported.This case describes a 24-year-old woman who underwent a hepatic lobectomy in 2008 for an ICC.Almost 4years after her surgery she presented with a pancreatic mass and lung nodules.An endoscopic ultrasound guided fine needle aspiration of the pancreatic mass and a video-assisted thoracoscopic surgery resection for the lung nodules were performed for diagnostic purposes.Pathological analyses of specimens revealed recurrence of her primary ICC in both pancreas and lungs.Subsequently,the patient received systemic chemotherapy.The patient is currently off chemotherapy and remains well.Moreover,she is pregnant.This is the first report of an ICC with pancreatic metastasis. | Isma?l Labgaa Gonzalo Carrasco-Avino Maria Isabel Fiel Myron Eliot Schwartz | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 2 |
| 3 | Alternative Flotation Methods, Adverse Seletion and Ownership Structure:Evidence from Seasoned Equity Issuance in the UK显示文摘 | Slovin Myron B Marie E Sushka and Kent W L Lai | 2001 | Journal of Financial Economics2001，，57： | 1 |
| 4 | Overview of vaccine and immunization 显示文摘 | Myron M Leviue James D Campbell Karen L Kotloff | 2002 | British Medical Bulletin2002，62，： | 1 |
| 5 | Family Management and Family Division in Contemporary Rural China 显示文摘 | MYRON L COHEN | 1992 | The China Quarterly1992，，130： | 1 |
| 6 | Some unusual erosion features in the loess of China 显示文摘 | Myron L Fuller | 1922 | Geographical Review1922，12，4： | 1 |
| 7 | Validity of exit interviews显示文摘 | Lefkowitz Joel Katz Myron L | 1969 | Personnel Psychology1969，，22： | 1 |
| 8 | Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults 显示文摘 | Anthony R H Kim B Myron J L | 1994 | Vir Immun1994，7，： | 1 |
| 9 | ~/-Glu- tamyltransferase is a predictor of incident diabetes and hypertension: The Coronary Artery Risk Develop- ment in Young Adults (CARDIA) study显示文摘 | DUK H L DAVID R MYRON G | 2003 | Clin Chem2003，49，： | 1 |
| 10 | The kinetics and Oxygen Exchange of the cupric Ion-catalysed Hydrolysis of a amino Esters显示文摘 | Myron L BByron W T | 1957 | J Am Chem1957，79，： | 1 |
| 11 | Generation of standard EM fields using TEMtransmission cells 显示文摘 | MYRON L C | 1974 | IEEE Transactions on Electromagnet-ic Compatibility1974，16，4： | 1 |
| 12 | Generation of standard EM fields using TEM transmission ceils 显示文摘 | Myron L C | 1974 | IEEE Transactions on Electromagnetic Compatibility1974，16，4： | 1 |
| 13 | Guidance and relative navigation for autonomous rendezvous in a circular orbit显示文摘 | HABLANI B HARI TAPPER L MYRON DANA-BASHIAN J DAVID | 2002 | Journal of Guidance Control and Dynamics2002，25，3： | 1 |
| 14 | Guidance and navigation for autonomous rendezvous in a circular orbit显示文摘 | Haft B Hablani Myron L Tapper David J dana-bashian | 2002 | Journal of Guidance Control and Dynamics2002，25，3： | 1 |
| 15 | Gas-turbine performanceimprovements through the use of multiple turbine inter-stage burners显示文摘 | Chen G Myron A H Roger L D | 2004 | Journal of Propulsion and Power2004，20，5： | 1 |
| 16 | Family Management and Family Division in Contemporary Rural China显示文摘 | Cohen Myron L | 1992 | The China Quarterly1992，，130： | 1 |
| 17 | γ- Glutamyltransferase is a predictor of incident diabetes and hypertension: The coronary artery risk development in young adults (CARDIA)study显示文摘 | Duk H L David R Myron G | 2003 | Clin Chem2003，49，8： | 1 |
| 18 | Survival after application of automatic external defibrillators before arrival of the emergency medical system: evaluation in the resuscitation outcomes consortium population of 21million 显示文摘 | Myron L Colleen M Joseph P | 2010 | JACC2010，55，16： | 1 |
| 19 | A Conceptual Framework of Faculty Trust and Participation in Governance 显示文摘 | MYRON L POPE | 2004 | New Direction for Adult and Continuing Education2004，，127： | 1 |
| 20 | Lithium and its compounds显示文摘 | Hader Rodney N Nielsen Richard L Herre Myron G | 1951 | Journal of Industrial and Engineering Chemistry1951，30，12： | 1 |
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