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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Physical Activity Constrains among Latinos 显示文摘 | Michelle G H Myron F F Jonathan M C | 2013 | Journal of Leisure Re- search2013，45，1： | 1 |
| 3 | Clinical indications for plasma protein assays:transthyretin (prealbumin)in inflammation and malnutrition 显示文摘 | MYRON JOHNSON A MERLINI G SHELDON J | 2007 | Clin Chem Lab Med2007，45，3： | 1 |
| 4 | Serum γ- Glutamyhransferase was differently associated with microalbuminuria by status of hyperten- sion or diabetes : the coronary artery risk development in young adults (CARDIA) study显示文摘 | Lee DH J R David G Myron | 2005 | Clin Chem2005，51，： | 1 |
| 5 | Soluble P-selectin and CD40L levels in subjects diabetes mellitus,and metabolic syndrome-urban rural epide-miology study显示文摘 | Kuppan G Raj D Myron DG | 2006 | Metabolism Clinical and Experimental2006，55，： | 1 |
| 6 | ~/-Glu- tamyltransferase is a predictor of incident diabetes and hypertension: The Coronary Artery Risk Develop- ment in Young Adults (CARDIA) study显示文摘 | DUK H L DAVID R MYRON G | 2003 | Clin Chem2003，49，： | 1 |
| 7 | Effect of temperature on the biology of Acyrthosiphon gossypii Mordvilko ( Homoptera: Aphidi- dae) on cotton显示文摘 | Gao G J Lynda E P Myron P | 2013 | Journal Pest Science2013，86，： | 1 |
| 8 | Effect of carotenoids on in vitro immunoglobulin production by human peripheral blood mononuclear cells: Astaxanthin, a carotenoid without vitamin A activity, enhances in vitro immunoglobulin production in response to a T-dependent stimulant and antigen 显示文摘 | JYONOUCHI H SUN S MYRON G | 1995 | Nutr Cancer1995，23，2： | 1 |
| 9 | 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host显示文摘 | LORRY G RUBIN MYRON J | 2014 | Clin Infect Dis2014，58，3： | 1 |
| 10 | Gas-turbine performanceimprovements through the use of multiple turbine inter-stage burners显示文摘 | Chen G Myron A H Roger L D | 2004 | Journal of Propulsion and Power2004，20，5： | 1 |
| 11 | Serum γ-Glutamyltransferase was differently associated with microalbuminuria by status of hypertension or diabetes:the coronary artery risk devepment in young adults(CARDIA)study显示文摘 | Lee DH David JR Myron G | 2005 | Clin Chem2005，51，： | 1 |
| 12 | γ-Glutamyltransferase is a predictor of incident diabetes and hypertension:the coronary artery risk development in young adults(CARDIA)study显示文摘 | Lee DH David RJ Myron G | 2003 | Clin Chem2003，49，： | 1 |
| 13 | γ- Glutamyltransferase is a predictor of incident diabetes and hypertension: The coronary artery risk development in young adults (CARDIA)study显示文摘 | Duk H L David R Myron G | 2003 | Clin Chem2003，49，8： | 1 |
| 14 | Lithium and its compounds显示文摘 | Hader Rodney N Nielsen Richard L Herre Myron G | 1951 | Journal of Industrial and Engineering Chemistry1951，30，12： | 1 |
| 15 | Clinical indications for plasma protein assays:transthy retin (prealbumin) in inflammation and malnutrition显示文摘 | Myron Johnson A Merlini G Sheldon J | | 0，，03： | 1 |
| 16 | Effect of Carotenoids on in vitro Immunoglobulin Production by Human Peripheral Blood Mononuclear Cells: Astaxanthin, a Carotenoids without Vitamin A Activity, Enhances in vitro Immunoglobulin Production in Response to a T-Dependent: Stimulant and Antigen 显示文摘 | JYONOUCHI H SUN S MYRON G | 1995 | Nutriton and Cancer1995，23，2： | 1 |
| 17 | y-glu-tamyltransferase is a predictor of incident diabetes and hypertension: the coronary artery risk development in young adults (cardia) study显示文摘 | DUK H L DAVID R MYRON G | 2003 | Clin Chem2003，8，： | 1 |
| 18 | γ - Glutamyhransferase is a pro- dictor of incident diabetes and hypertension: the coronary artery risk development in young adults (CARDIA) study显示文摘 | Lee DH David R J Myron G | 2003 | Clin Chem2003，49，： | 1 |
| 19 | The Albumin in acute stroke (ALIAS) multicenter clinical triM: safety analysis of part 1, and rationale and design of part 2显示文摘 | Myron D G Yuko Y P Renee H M | 2011 | Sroke2011，42，1： | 1 |
| 20 | Neuroproteetion for ischemiestroke: Past, present and future 显示文摘 | Myron D G | 2008 | Neuropharmacology2008，55，： | 1 |
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