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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | SLC2A9 is a high-capacity urate transporter in humans 显示文摘 | Caulfield M J Munroe P B O'Neill D | 2008 | PLoS Med2008，5，10： | 1 |
| 3 | SLC2A9 is a high-capacity urate transporter in humans显示文摘 | Caulfield M J Munroe PB O' Neill D | 2008 | PLoS Med2008，5，： | 1 |
| 4 | Marine natural prod- uets显示文摘 | Blunt J W Copp B R Munro M G H | 2004 | Nat Prod Rep2004，21，1： | 1 |
| 5 | Laboratory study of the influence of prey size on vulnerability to cannibalism in snow crab Chinonoecetes opilio ( Fabricius 1780) 显示文摘 | Dutil J D Munro J Peloquin M | 1997 | Journal of Experimental Marine Biology and Ecology1997，14，： | 1 |
| 6 | Molecular characteriza- tion of a peripheral receptor for cannabinoids显示文摘 | Munro S Thomas K L Abu-Shaar M | 1993 | Nature1993，365，6441： | 1 |
| 7 | Threshold criteria for incipient sediment motion on an inclined bedform in the presence of oscillating-grid turbulence显示文摘 | WAN MOHTAR W H M MUNRO R J | 2013 | Physics of Fluids2013，25，01： | 1 |
| 8 | Chitin synthesis and fungal pathogenesis显示文摘 | Lenardon M D Munro C A Gow N A | 2010 | Curr Opin Microbiol2010，13，： | 1 |
| 9 | Mammary duct ectasia in children:report of a short series and review of the literature显示文摘 | McHoney M Munro F Mackinlay G | 2011 | Early Hum Dev2011，87，8： | 1 |
| 10 | Association of lymphadenectomy and survival in stage I ovarian cancer patients 显示文摘 | CHAN J K MUNRO E G CHEUNG M K | 2007 | Obstet Gynecol2007，109，1： | 1 |
| 11 | Analysis of the Fecal Microflora of Human Subjects Consuming a Probiotic Product Containing Lac- tobacillus rhamnosus DR20显示文摘 | TANNOCK G W MUNRO K HARMSEN H J M | 2000 | Appl Environ Micro-biol2000，66，： | 1 |
| 12 | Study of particle nucleation, flocculation, and growth in the emulsion -free polymerization of styrene in water intensity light scattering and photon correlation spectroscopy 显示文摘 | Munro D Goodall A R Wilkinson M C | 1979 | J Conoid Interface Sci1979，68，： | 1 |
| 13 | Soy isoflavones:a safety review显示文摘 | Munro IC Harwood M Hlywka JJ | 2003 | Nutr Rev2003，61，1： | 1 |
| 14 | Electroki- netic control of fluid flow in native poly (dimethyl- siloxane) capillary electrophoresis devices 显示文摘 | Ocvirk G Munroe M Tang T | 2000 | E- lectrophoresis2000，21，： | 1 |
| 15 | The effect of cooking and washing temperature during pilot-scale rennet casein manufacture on casein hydration characteristics in disodium orthophosphate solution显示文摘 | O'SULLIVAN M M SINGH H MUNRO P A | 2002 | International Journal of Dairy Technology2002，55，1： | 1 |
| 16 | Investigation of the effect of type 2 diabetes mellitus on subgingival plaque microbiota by high -throughput 16S rDNA pyrosequeneing 显示文摘 | Zhou M Rong R Munro D | 2013 | PLoS One2013，228，61： | 1 |
| 17 | 查看详情显示文摘 | M D Reid W J Munro F De Martini | | 0，，03： | 1 |
| 18 | Mammary duct ectasia in children: report of a short series and review of the literature 显示文摘 | McHoney M Munro F Mackinlay G | 2011 | Early Hum Dev2011，87，8： | 1 |
| 19 | An association study of the neurotensin receptor gene with schizophrenia and c显示文摘 | Huezo-Diaz P Arranz M J Munro J | 2004 | Schizophr Res2004，66，23： | 1 |
| 20 | Oral Health and Care in the Intensive Care Unit:State of the Science显示文摘 | Munro C L Grap M J Ruth K | 2004 | Am J Crit Care2004，13，1： | 1 |
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