|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway显示文摘BACKGROUND Liver fibrosis is a refractory disease whose persistence can eventually induce cirrhosis or even liver cancer.Early liver fibrosis is reversible by intervention.As a member of the transforming growth factor-beta(TGF-β)superfamily,bone morphogenetic protein 7(BMP7)has anti-liver fibrosis functions.However,little is known about BMP7 expression changes and its potential regulatory mechanism as well as the relationship between BMP7 and TGF-βduring liver fibrosis.In addition,the mechanism underlying the anti-liver fibrosis function of BMP7 needs to be further explored.AIM To investigate changes in the dynamic expression of BMP7 during liver fibrosis,interactions between BMP7 and TGF-β1,and possible mechanisms underlying the anti-liver fibrosis function of BMP7.METHODS Changes in BMP7 expression during liver fibrosis and the interaction between BMP7 and TGF-β1 in mice were observed.Exogenous BMP7 was used to treat mouse primary hepatic stellate cells(HSCs)to observe its effect on activation,migration,and proliferation of HSCs and explore the possible mechanism underlying the anti-liver fibrosis function of BMP7.Mice with liver fibrosis received exogenous BMP7 intervention to observe improvement of liver fibrosis by using Masson’s trichrome staining and detecting the expression of the HSC activation indicator alpha-smooth muscle actin(α-SMA)and the collagen formation associated protein type I collagen(Col I).Changes in the dynamic expression of BMP7 during liver fibrosis in the human body were further observed.RESULTS In the process of liver fibrosis induced by carbon tetrachloride(CCl4)in mice,BMP7 protein expression first increased,followed by a decrease;there was a similar trend in the human body.This process was accompanied by a sustained increase in TGF-β1 protein expression.In vitro experiment results showed that TGF-β1 inhibited BMP7 expression in a time-and dose-dependent manner.In contrast,high doses of exogenous BMP7 inhibited TGF-β1-induced activation,migration,and proliferation of HSCs;this inhibitory effect was associated with upregulation of pSmad1/5/8 and downregulation of phosphorylation of Smad3 and p38 by BMP7.In vivo experiment results showed that exogenous BMP7 improved liver fibrosis in mice.CONCLUSION During liver fibrosis,BMP7 protein expression first increases and then decreases.This changing trend is associated with inhibition of BMP7 expression by sustained upregulation of TGF-β1 in a time-and dose-dependent manner.Exogenous BMP7 could selectively regulate TGF-β/Smad pathway-associated factors to inhibit activation,migration,and proliferation of HSCs and exert antiliver fibrosis functions.Exogenous BMP7 has the potential to be used as an antiliver fibrosis drug. | Gao-Liang Zou Shi Zuo Shuang Lu Rui-Han Hu Yin-Ying Lu Jing Yang Kai-Sheng Deng Ye-Ting Wu Mao Mu Juan-Juan Zhu Jing-Zhang Zeng Bao-Fang Zhang Xian Wu Xue-Ke Zhao Hai-Yang Li | 2019 | World Journal of Gastroenterology2019，25，30： | 15 |
| 2 | Flexible and wearable BaTiO_(3)/polyacrylonitrile-based piezoelectric sensor for human posture monitoring显示文摘Tactile sensors are essential components of wearable electronic devices,but there are still various problems in terms of energy supply,flexibility and skin adaptability.In this paper,we report a self-powered flexible tactile sensor(FTS)mainly composed of a BaTiO_(3)/polyacrylonitrile/Ecoflex(BTO/PAN/Ecoflex)composite film,which can be used for dynamically monitoring human plantar pressure,posture and other physiological and motion parameters.Combining the synergistic piezoelectric properties of PAN and BTO,the output voltage/current of the BTO/PAN/Ecoflex composite film is 4.5/5.8 times that of the BTO/Ecoflex composite film,with maximum instantaneous power that can reach up to 3.375μW.Under the action of external pressure stress,the FTS can reach a normalized voltage sensitivity and voltage linearity of 0.54 V/N and 0.98,respectively.Furthermore,a human-machine interaction test system is built,which can display the stress changes of human body monitoring parts in real time according to voltage changes and different color assignments.The developed human-machine interaction test system provides a new idea for the diagnosis of flatfoot and other medical diseases.Hence,this work proposes new FTSs that use a BTO/PAN/Ecoflex composite film with high sensitivity and great output performance,thus exhibiting immense potential application prospects in medical research,personalized recognition and human-machine interaction. | MU JiLiang XIAN Shuai YU JunBin LI ZhengYang ZHAO JuanHong ZHONG JiXin HAN XiaoTao HOU XiaoJuan HE Jian CHOU XiuJian | 2022 | Science China(Technological Sciences)2022，65，4： | 3 |
| 3 | A review of helical carbon materials structure,synthesis and applications显示文摘The helical structures possess unique physical and chemical properties,such as superelasticity,high specific strength,chirality,and electromagnetic cross-polarization characteristics.With the development of nanoscience and nanotechnology,helical structures with various scales have been discovered or synthesized artificially.Among them,the helical carbon materials receive much attention around the world.Herein,we present a brief review of the development of helical carbon materials in terms of structures,synthesis techniques and mechanisms,and applications.The controllable designing of catalysts,carbon sources and reaction parameters plays a key role to optimize the properties of the helical carbon materials.At the same time,the applications in microwave absorption devices,sensors,catalysts,energy conversions and storage devices,and solar cell are also presented.For the good chemical and physical properties,helical carbon materials have a good application prospect in many fields.The potential issues and future opportunities of the helical carbon materials are also proposed. | Ding-Chuan Wang Yu Lei Wei Jiao Yi-Fan Liu Chun-Hong Mu Xian Jian | 2021 | Rare Metals2021，40，1： | 3 |
| 4 | Synergistic piezoelectricity enhanced BaTiO_(3)/polyacrylonitrile elastomer-based highly sensitive pressure sensor for intelligent sensing and posture recognition applications显示文摘Designing stretchable and skin-conformal self-powered sensors for intelligent sensing and posture recognition is challenging.Here,based on a multi-force mixing and vulcanization process,as well as synergistically piezoelectricity of BaTiO_(3)and polyacrylonitrile,an all-in-one,stretchable,and self-powered elastomer-based piezo-pressure sensor(ASPS)with high sensitivity is reported.The ASPS presents excellent sensitivity(0.93 V/104 Pa of voltage and 4.92 nA/104 Pa of current at a pressure of 10-200 kPa)and high durability(over 10,000 cycles).Moreover,the ASPS exhibits a wide measurement range,good linearity,rapid response time,and stable frequency response.All components were fabricated using silicone,affording satisfactory skinconformality for sensing postures.Through cooperation with a homemade circuit and artificial intelligence algorithm,an information processing strategy was proposed to realize intelligent sensing and recognition.The home-made circuit achieves the acquisition and wireless transmission of ASPS signals(transmission distance up to 50 m),and the algorithm realizes the classification and identification of ASPS signals(accuracy up to 99.5%).This study proposes not only a novel fabrication method for developing self-powered sensors,but also a new information processing strategy for intelligent sensing and recognition,which offers significant application potential in human-machine interaction,physiological analysis,and medical research. | Junbin Yu Shuai Xian Zhenpeng Zhang Xiaojuan Hou Jian He Jiliang Mu Wenping Geng Xiaojun Qiao Le Zhang Xiujian Chou | 2023 | Nano Research2023，16，4： | 2 |
| 5 | Strain-regulated sensing properties of α-Fe_(2)O_(3) nano-cylinders with atomic carbon layers for ethanol detection显示文摘The sensitivity of ethanol sensor is of paramount importance in a variety of areas,including chemical production with ethanol,alcohol testing for driving safety,etc.Herein,α-Fe_(2)O_(3) nano-cylinders with atomic carbon layers are synthesized,for the first time,through in-situ catalytic chemical vapor deposition combined with hydrothermal techniques for the detection of ethanol.The reported α-Fe_(2)O_(3)@C nano-cylinders with double surficial strain effects deliver an ethanol detection sensitivity of 8 times as compared with α-Fe_(2)O_(3) nano-cylinders,10 times higher as compared with its detection sensitivity to ammonia,para-xylene,methanol and benzene.The sensor also exhibits over-14-day operation stability and the minimum detection limit of 10 ppm.To our best knowledge,the performances surpass those of previously reported α-Fe_(2)O_(3).Such attractive performances are attributed to the enhanced charge transfer in α-Fe_(2)O_(3) owing to the double surficial strain effects of α-Fe_(2)O_(3)@C nano-cylinders and the efficient adsorption of ethanol with atomic carbon layers. | Huajing Xiong Jianan Fu Jinyao Li Rashad Ali Hong Wang Yifan Liu Hua Su Yuanxun Li Woon-Ming Lau Nasir Mahmood Chunhong Mu Xian Jian | 2021 | Journal of Materials Science & Technology2021，，9： | 2 |
| 6 | Enantioselective Iridium‐Catalyzed Hydrogenation of 1‐ and 3‐Substituted Isoquinolinium Salts显示文摘 | Zhi‐Shi Ye Ran‐Ning Guo Xian‐Feng Cai Mu‐Wang Chen Lei Shi Yong‐Gui Zhou | 2013 | Angew Chem Int Ed2013，，13： | 1 |
| 7 | Hypomethylation of perforin regulatory elements in CD4 <sup>+</sup> T cells from rat spleens contributes to the development of autoimmune emphysema显示文摘 | Cheng Zhang Mu‐Yun Yan Ping Lu Ping Chen Min Yang Xian‐Wei Ye Mei Xu Zhang‐Hong Ou Yang Xiang‐Yan Zhang | 2014 | Respirology2014，，3： | 1 |
| 8 | Size effects on the tensile strength and fracture toughness of granitic rock in different tests显示文摘This study investigates the tensile failure mechanisms in granitic rock samples at different scales by means of different types of tests.To do that,we have selected a granitic rock type and obtained samples of different sizes with the diameter ranging from 30 mm to 84 mm.The samples have been subjected to direct tensile strength(DTS)tests,indirect Brazilian tensile strength(BTS)tests and to two fracture toughness testing approaches.Whereas DTS and fracture toughness were found to consistently grow with sample size,this trend was not clearly identified for BTS,where after an initial grow,a plateau of results was observed.This is a rather complete database of tensile related properties of a single rock type.Even if similar databases are rare,the obtained trends are generally consistent with previous scatter and partial experimental programs.However,different observations apply to different types of rocks and experimental approaches.The differences in variability and mean values of the measured parameters at different scales are critically analysed based on the heterogeneity,granular structure and fracture mechanics approaches.Some potential relations between parameters are revised and an indication is given on potential sample sizes for obtaining reliable results.Extending this database with different types of rocks is thought to be convenient to advance towards a better understanding of the tensile strength of rock materials. | Ignacio Pérez-Rey Andrea Muñoz-Ibáñez Manuel A.González-Fernández Mauro Muñiz-Menéndez Miguel Herbón Penabad Xian Estévez-Ventosa Jordi Delgado Leandro RAlejano | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，9： | 1 |
| 9 | Hybrid electromechanical properties of hetero-doped and homogeneously bonded dual-mode pressure sensor for indoor body area network node显示文摘Pressure sensors are considerably important for continuous monitoring of human movement and the surrounding environment to construct a caregiving system for the elderly living alone.The challenge for pressure sensors that still remains is combining self-driven,comfort,and multifunctionalization.Herein,an all-in-one conformal pressure sensor(ACPS) based on a homogeneous integrated triboelectric-piezoelectric hybrid sensor is proposed.The ACPS has dual-mode sensing properties due to coupling triboelectrification and piezoelectric effect ensuring a stable response to various external stimulations.Silver-coated glass microspheres and polyacrylonitrile were uniformly filleted into the silicone rubber substrate using a hetero-doping method to create a stretchable electrode layer with flexible conformal characteristics and a piezoelectric layer with excellent piezoelectric properties,respectively.Meanwhile,the triboelectric layer was fabricated using the same silicone rubber,allowing ACPS to be homogeneously bonded into an all-in-one structure with reliable durability.This allowed various functional layers to have outstanding interface characteristics and thus improve the electrical transmission effect.The developed ACPS had outstanding sensitivity(1.04 V/10~4Pa),high linearity(about 0.984),a wide measurement range(10–700 k Pa),and can accurately and continuously distinguish multiple movements.Furthermore,using a homemade signal processing circuit,ACPSs can be deployed in the human body and the room as indoor body area network nodes.When successfully applied to the remote tracking of daily dynamic home life and the remote operation of small electrical equipment,these ACPSs can achieve real-time caregiving for the elderly living alone.As an application area desperately needed by society,this study envisions a caregiving system for the elderly living alone without violating personal privacy. | Junbin YU Shuai XIAN Jinbiao MU Min WANG Yin WANG Xiaojuan HOU Le ZHANG Jian HE Jiliang MU Xiujian CHOU | 2024 | Science China(Information Sciences)2024，67，1： | 0 |
| 10 | Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment显示文摘Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS. However, this disease has actually received little attention and has been underrepresented by relatively low publication volume and quality. Based on systematically reviewed literature and practical experiences of expert members, our consensus focuses on characteristics, symptoms, classification and diagnosis of OMS, and further put forward multidisciplinary treatment decisions for OMS, as well as the common treatment complications and relative managements. This consensus aims to increase attention to OMS, and optimize the clinical diagnosis and decision-making of OMS, which finally provides evidence-based options for OMS clinical management. | Jiang Lin Chengshuo Wang Xiangdong Wang Faming Chen Wei Zhang Hongchen Sun Fuhua Yan Yaping Pan Dongdong Zhu Qintai Yang Shaohua Ge Yao Sun Kuiji Wang Yuan Zhang Mu Xian Ming Zheng Anchun Mo Xin Xu Hanguo Wang Xuedong Zhou Luo Zhang | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 11 | New Nuclide Protactinium-239显示文摘New Nuclide Protactinium-239NewNuclideProtactinium-239￥YuanShuanggui;YangWeifan;MuWantong;ZhangXueqian;LiZongwei;YuXian;GuJin... | Yuan Shuanggui Yang Weifan Mu Wantong Zhang Xueqian Li Zongwei Yu Xian Gu Jinnan Guo Yingxiang Gan Zaiguo Liu Hongye Zhao Jinhua Let Xiangguo Guo Junsheng Du Yifei Guo Tianrui Zhao Lin and Zhang Xiang | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 12 | γ Decay of New Neutron-rich Nuclei ^(175)Er显示文摘γ Decay of New Neutron-rich Nuclei ^(175)ErγDecayofNewNeutron-richNuclei^(175)Er￥ZhangXueqian;YuanShuanggui;YangWeifan;YuXian;... | Zhang Xueqian Yuan Shuanggui Yang Weifan Yu Xian Mu Wantong Li Zongwei Sun Xiangfu Zhong Jiquan Gan Zaiguo Guo Tianrui Du Yifei Gu Jinnan and Luo Yixiao | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 13 | A QUANTUM CHEMISTRY STUDY ON THE SIZE-DEPENDENCE OF THE CHEMISORPTION OF AMMONIA AND CARBON MONOXIDE ON ALUMINUM CLUSTERS显示文摘The chemisorption intensities of NH3 and CO on aluminum clusters A1n(n=l-13)have been theoretically predicted by using CNDO/2 method and properly selecting the clusters’geometries.The results show that the chemisorptions of NH3 and GO on Al2,Al6 and Al12 aremagically stable and thus are in good agreement with the experimental results.In addition,anelectronic structure analysis is made to expound the nature of such a size effect. | Lin Feng LI Xian Zhang GU Mu Zhen LIAO and Guo Shi WU Department of Chemistry,Tainghua University,Beijing 100084 | 1991 | Chinese Chemical Letters1991，2，3： | 0 |
| 14 | THE ELECTROSTATIC POTENTIAL METHOD APPLIED TO THE KINETICS OF INTERMOLECULAR ELECTRON TRANSFER IN PHOTOELECTRIC CONVERSION显示文摘A thorough investigation have been first carried out on the electron trans-ferring between molecules by using the ab initio electrostatic potential method.By thismethod,we made a theoretical estimation of the energy barrier that electrons tunnel whenthey move from one molecule to another.The results show that for two molecules veryclose to each other the height of the barrier goes down exponentially with a decreasingintermolecular distance.Substituting groups have effect on the height of the barrier.The photoelectric current produced in a simulative system has also been theoreticallypredicted. | Xuan CAO Mu Zhen LIAO Xian Zhang GU Lin Feng LI Guo Shi WU (Department of Chemistry,Tsinghua University,Beijing 100084) | 1991 | Chinese Chemical Letters1991，2，4： | 0 |
| 15 | 一氧化氮通过调控蛋白质甲基化修饰介导植物胁迫反应显示文摘文章简介甲基化和一氧化氮(NO)依赖的S-亚硝基化是高度保守的两种蛋白质翻译后修饰,其参与调控众多生物学过程。在高等真核生物中,蛋白质精氨酸甲基转移酶5(PRMT5)催化蛋白质的精氨酸对称性双甲基化修饰,其底物包括pre-m RNA剪接复合体的多个核心组分。 | 胡济梁 杨焕杰 Jinye Mu Tiancong Lu Juli Peng Xian Deng 孔照胜 鲍时来 曹晓风 左建儒 | 2018 | 科学新闻2018，0，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员