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| 1 | Bacteremia in hemodialysis patients显示文摘Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant Staphylococcus aureus infection. The most common site of infection causing bacteremia is internal prostheses; the use of a hemodialysis catheter is the most important risk factor for bacteremia. Although antibiotic lock of hemodialysis catheters and topical antibiotic ointment can reduce catheter-related blood stream infection(CRBSI), their use should be limited to necessary cases because of the emergence of resistant organisms. Systemic antibiotic administration and catheter removal is recommended for treating CRBSI, although a study indicated the advantages of antibiotic lock and guidewire exchange of catheters over systemic antibiotic therapy. An infection control bundle recommended by the Center for Disease Control and Prevention succeeded in reducing bacteremia in hemodialysis patients with either a catheter or arteriovenous fistula. Appropriate infection control can reduce bacteremia in hemodialysis patients. | Masashi Suzuki Nobuhiko Satoh Motonobu Nakamura Shoko Horita George Seki Kyoji Moriya | 2016 | World Journal of Nephrology2016，5，6： | 14 |
| 2 | Gastro-esophageal reflux disease symptoms are more common in general practice in Japan显示文摘AIM: To accurately assess the prevalence of GERD symptoms in general practice. METHODS: 4139 consecutive patients (2025 men and 2114 women with a mean age of 43 years), who fi rst attended the Outpatient Department of General Medicine and Emergency Care at Toho University Omori Hospital, were asked to respond to the F-scale questionnaire regardless of their chief complaints. The questionnaire is a self-report instrument, written in a simple and easy-to-understand language, containing 12 questions. RESULTS: Of 4139 subjects, 1554 patients (37.6%) were identifi ed as GERD according to their F-scale score (> 7). However, there were only 45 consultations (1.1%) for typical GERD symptoms. Although GERD symptoms are common in adults of all ages, the prevalence of GERD was highest in the 20-29 years age group and the age group 70-79 years had the lowest prevalence for both males and females. CONCLUSION: Although there was a high rate indicating GERD in our primary care population, only 1.1% of outpatients attended our hospital with a chief complaint of GERD symptoms. Since about one-third of GERD patients are affected by atypical symptoms, general physicians need to be cautious about extrapolating these results to patients with a chief complaint other than typical GERD symptoms. | Toshiyasu Watanabe Yoshihisa Urita Motonobu Sugimoto Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，31： | 12 |
| 3 | Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer显示文摘 | Yuji Maehata Shotaro Nakamura Kiyoshi Fujisawa Motohiro Esaki Tomohiko Moriyama Kouichi Asano Yuta Fuyuno Kan Yamaguchi Issei Egashira Hyonji Kim Motonobu Kanda Minako Hirahashi Takayuki Matsumoto | 2012 | Gastrointestinal Endoscopy2012，，1： | 10 |
| 4 | Prevalence of linked angina and gastroesophageal reflux disease in general practice显示文摘AIM: To evaluate the association between gastroesophageal re? ux diseases (GERD) and coronary heart diseases. METHODS: One thousand nine hundred and seventy consecutive patients who attended our hospital were enrolled. All of the patients who first attend our hospital were asked to respond to the F-scale questionnaire regardless of their chief complaints. All patients had a careful history taken, and resting echocardiography (ECG) was performed by physicians if the diagnostic necessity arose. Patients with ECG signs of coronary artery ischemia were defined as STsegment depression based on the Minnesota code. RESULTS: Among 712 patients (36%) with GERD, ECG was performed in 171 (24%), and ischemic changes were detected in eight (5%). Four (50%) of these patients with abnormal findings upon ECG had no chest symptoms such as chest pain, chest oppression, or palpitations. These patients (0.6%; 4/712) were thought to have non-GERD heartburn, which may be related to ischemic heart disease. Of 281 patients who underwent ECG and did not have GERD symptoms, 20 (7%) had abnormal findings upon ECG. In patients with GERD symptoms and ECG signs of coronary artery ischemia, the prevalence of linked angina was considered to be 0.4% (8/1970 patients).CONCLUSION: The present study suggested that ischemic heart disease might be found although a patient was referred to the hospital with a complaint of GERD symptoms. Physicians have to be concerned about missing clinically important coronary artery disease while evaluating patients for GERD symptoms. | Hirohito Kato Takamasa Ishii Tatsuo Akimoto Yoshihisa Urita Motonobu Sugimoto | 2009 | World Journal of Gastroenterology2009，15，14： | 5 |
| 5 | Cerebral infarction in the caudate nucleus associated with acute epidural hematoma and diffuse brain injury in a child after severe head injury显示文摘 | Miki Fujimura Motonobu Kameyama Osamu Motohashi Hiroyuki Kon Kiyoshi Ishii Takehide Onuma | 2004 | Child’s Nervous System2004，，6： | 2 |
| 6 | Link betweenHelicobacter pylori-associated gastritis and duodenal ulcer显示文摘 | Hiroshi Saita Dr. Motonobu Murakami Jung Kenn Yoo Sanae Teramura Hiroshi Dekigai Youji Takahashi Toru Kita | 1993 | Digestive Diseases and Sciences1993，，1： | 1 |
| 7 | Characteristics of pectin extracted from citrus peel using subcritical water显示文摘 | Munehiro Hoshino Masahiro Tanaka Akihiro Terada Mitsuru Sasaki Motonobu Goto | 2009 | Journal of Bioscience and Bioengineering2009，，： | 1 |
| 8 | Drilling of Lead Free brass Alloy 'ECOBRASSO' 显示文摘 | Toshikazu Matsumoto Motonobu Furuya | 2002 | Journal of the Japan Copper and Brass Research Association2002，41，1： | 1 |
| 9 | Hydrothermaldecomposition of yeast cells for production of proteins and amino acids显示文摘 | Wiwat Lamoolphak Motonobu Goto Mitsuru Sasaki | 2006 | Journal of Hazardous Materials2006，137，： | 1 |
| 10 | Stability of transferred human chromosome fragments in cultured cells and in mice显示文摘 | Tokuyuki Shinohara Kazuma Tomizuka Shoko Takehara Kaori Yamauchi Motonobu Katoh Atsuko Ohguma Isao Ishida Mitsuo Oshimura | 2000 | Chromosome Research2000，，8： | 1 |
| 11 | Adiponectin levels associated with the development of hypertension: a prospective study显示文摘 | TAKUYA I MOTONOBU M YOSHITO M | 2008 | Hypertens Res2008，31，2： | 1 |
| 12 | Does Elevated High- Sensitivity Serum C-Reactive Protein Associate with Hypertension in Non-Obese Japanese Males显示文摘 | Takuya Imatoh Motonobu Miyazaki Hiroshi Une | 2007 | Clinical and Experimentai Hypertension2007，29，8： | 1 |
| 13 | VzO5-WO3/TiO2- SiO2-SO42- catalysts: influence of active components and supports on activities in the selective catalytic reduction of NO by NH3 and in the oxidation of SO2 显示文摘 | Motonobu Kobayashi Mitsuharu Hagi | 2006 | Applied Catalysis B: Environmental2006，63，12： | 1 |
| 14 | A p53-type response element in the GDF15 promoter confers high specificity for p53 activation 显示文摘 | Motonobu Osada Hannah Lui Park Min Joo Park | 2007 | Biochemical and Biophysical Research Communications2007，354，4： | 1 |
| 15 | Development of dioxins decomposition catalyst 显示文摘 | Noboru Sugishima Motonobu Kobayashi | 2001 | Catalysts & Catalysis2001，43，7： | 1 |
| 16 | A new PSA process as an ex tension of the Petlyuk distillation concept 显示文摘 | Dong Fei Eou Hongmei Goto Motonobu | 1999 | Separation and Purification Technology1999，15，： | 1 |
| 17 | Single Administration of Thrombopoietin Prevents Progression of Liver Fibrosis and Promotes Liver Regeneration After Partial Hepatectomy in Cirrhotic Rats显示文摘 | Soichiro Murata Ikuka Hashimoto Yoritaka Nakano Andriy Myronovych Motonobu Watanabe Nobuhiro Ohkohchi | 2008 | Annals of Surgery2008，，5： | 1 |
| 18 | Role of platelets on liver regeneration after 90% hepatectomy in mice显示文摘 | Andriy Myronovych Soichiro Murata Mitsuru Chiba Ryota Matsuo Osamu Ikeda Motonobu Watanabe Katsuji Hisakura Yoritaka Nakano Keisuke Kohno Takuya Kawasaki Ikuka Hashimoto Yuki Shibasaki Hiroshi Yasue Nobuhiro Ohkohchi | 2008 | Journal of Hepatology2008，，3： | 1 |
| 19 | WO3 - TiO2 Monolithic Catalysts for High Temperature SCR of NO by NH3 : Influence of Preparation Method on Structural and Physico - chemical Properties, Activity and Durability 显示文摘 | Kobayashi Motonobu Miyoshi Katsunori | 2007 | Applied Catalysis B : Environmental2007，72，34： | 1 |
| 20 | Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma显示文摘 | Pin Liang Jian-Wei Hong Hideyuki Ubukata Huan-Ran Liu Yoshinori Watanabe Motonobu Katano Gyo Motohashi Teruhiko Kasuga Ichiro Nakada Takafumi Tabuchi | 2006 | Virchows Archiv2006，，5： | 1 |
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