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| 1 | Recent insights in the pathogenesis of post-transplantation lymphoproliferative disorders显示文摘Post-transplant lymphoproliferative disorder(PTLD) is an aggressive complication of solid organ and hematopoietic stem cell transplantation that arises in up to 20% of transplant recipients. Infection or reactivation of the Epstein-Barr virus(EBV), a ubiquitous human herpesvirus, in combination with chronic immunosuppression are considered as the main predisposing factors, however insight in PTLD biology is fragmentary. The study of PTLD is complicated by its morphological heterogeneity and the lack of prospective trials, which also impede treatment optimization. Furthermore, the broad spectrum of underlying disorders and the graft type represent important confounding factors. PTLD encompasses different malignant subtypes that resemble histologically similar lymphomas in the general population. Post-transplant diffuse large B-cell lymphoma(PT-DLBCL), Burkitt lymphoma(PTBL) and plasmablastic lymphoma(PT-PBL) occur most frequently. However, in many studies various EBV+ and EBV- PTLD subtypes are pooled, complicating the interpretation of the results. In this review, studies of the gene expression pattern, the microenvironment and the genetic profile of PT-DLBCL, PT-BL and PT-PBL are summarized to better understand the mechanisms underlying post-transplantation lymphomagenesis. Based on the available findings we propose stratification of PTLD according to the histological subtype and the EBV status to facilitate the interpretation of future studies and the establishment of clinical trials. | Julie Morscio Thomas Tousseyn | 2016 | World Journal of Transplantation2016，6，3： | 11 |
| 2 | Validation of Prognostic Scores in Post-Transplantation Lymphoproliferative Disorders显示文摘 | Daan Dierickx Thomas Tousseyn Julie Morscio Steffen Fieuws Gregor Verhoef | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 3 | Single-center analysis of biopsy-confirmed posttransplant lymphoproliferative disorder: incidence, clinicopathological characteristics and prognostic factors显示文摘 | Daan Dierickx Thomas Tousseyn Xavier Sagaert Steffen Fieuws Iwona Wlodarska Julie Morscio Lieselot Brepoels Dirk Kuypers Johan Vanhaecke Frederik Nevens Geert Verleden Rita Van Damme-Lombaerts Marleen Renard Jacques Pirenne Christiane De Wolf-Peeters Greg | 2013 | Leukemia & Lymphoma2013，，11： | 1 |
| 4 | Clinicopathological char-acteristics of posttransplant lymphoproliferative disorders of T-cellorigin: single-center series of nine cases and meta-analysis of 147 re-ported cases显示文摘 | Herreman A Dierickx D Morscio J | 2013 | Leuk Lymphoma2013，54，10： | 1 |
| 5 | Clinicopathologic Comparison of Plasmablastic Lymphoma in FIN-positive, Immunocompetent, and Posttransplant Patients: single-center series of 25 cases and recta-analysis of 277 reported cases 显示文摘 | Morscio J Dierickx D Nijs J | 2014 | Am J Surg Pathol2014，38，： | 1 |
| 6 | Clinicopathologic compari- son of plasmablastic lymphoma in HIV-positive, immunocompe- tent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases 显示文摘 | Morscio J Dierickx D Nijs J | 2014 | Am J Surg Pathol2014，38，7： | 1 |
| 7 | Clinicopathologic comparison of plasmablastic lymphoma in HIV-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases显示文摘 | Morscio J Dierickx D Nijs J | 2014 | Am J Surg Pathol2014，38，7： | 1 |
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