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| 1 | Cirrhotic ascites review: Pathophysiology, diagnosis and management显示文摘Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities. | Christopher M Moore David H Van Thiel | 2013 | World Journal of Hepatology2013，5，5： | 13 |
| 2 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 3 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 4 | High prevalence of antifungal resistance in Candida spp from patients with AIDS 显示文摘 | Law D Moore C B Wardle H M | 1994 | J Antimicrob Chemother1994，34，5： | 2 |
| 5 | HMG-CoA reductase guides migrating primordial germ cells显示文摘 | van Doren M Broihier H T Moore L A | 1998 | Nature1998，396，6710： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | Vaginal yeast colonization in nonpregnant women: a longitudinal study显示文摘 | Beigi R H Meyn L A Moore D M | 2004 | Obstet Gynecol2004，104，： | 1 |
| 8 | Dextrous hand grasping force optimization显示文摘 | Buss M Hashimoto H Moore J | 1996 | IEEE Transactions on Robotics and Automation1996，12，3： | 1 |
| 9 | De-mand articulation in emerging technologies: intermediary user organisations as co-producers? 显示文摘 | BOON W P C MOORS E H M KUHLMANN S | 2010 | Research Policy2010，40，2： | 1 |
| 10 | Improvements in survival and clinical benefit with gemcitabine as first-line theraphy for patients with advanced pancreas cancer:a randomized trial显示文摘 | Burris H Moore M J Anderson J | 1997 | Journal of Clinical Oncology1997，15，4： | 1 |
| 11 | Stratospheric residence time of strontium,90 显示文摘 | Kuroda P K Hodges H L Fry L M Moore H E | 1962 | Science1962，137，3523： | 1 |
| 12 | Can the concepts of depression and quality of life be integrated using a time perspective显示文摘 | Moor M Hofer S McGee H | | 0，，： | 1 |
| 13 | Increasing rates of cardiac device infections among medicare beneficiaries: 1990–1999显示文摘 | Christopher H Cabell Paul A Heidenreich Vivian H Chu Christopher M Moore Martin E Stryjewski G.Ralph Corey Vance G Fowler | 2004 | American Heart Journal2004，，4： | 1 |
| 14 | Single step method for the accurate concentration determination of polysorbate 80显示文摘 | TANI T H MOORE J M PATAPOFF T W | 1997 | J Chromatogr A1997，786，1： | 1 |
| 15 | A quantitative analysis of intron effects on mammalian gene expression 显示文摘 | Nott A Meislin S H Moore M J | 2003 | RNA2003，9，5： | 1 |
| 16 | Comparative expression analysis of two sugarcane polyubiquitin promoters and flanking sequences in transgenic plants显示文摘 | Wei H Wang M L Moore P H | 2003 | J Plant Physiol2003，160，10： | 1 |
| 17 | Seismic Pumping:a Hydrothermal Fluid Transport Mechanism显示文摘 | Sibson R H Moore J M M Rankin A H | 1975 | Journal of the Geological Society1975，131，6： | 1 |
| 18 | Loss of purinergic P2X receptor innervation in human detrusor and subepthelium from adults with sensory urgency显示文摘 | Ray F R Moore K H Hansen M A | 2003 | Cell Tissue Res2003，314，3： | 1 |
| 19 | The incidence and control of apple scab and apple mildew at East Mailing 显示文摘 | Moore M H | 1930 | Journal of Pomology and Horticultural Science1930，8，： | 1 |
| 20 | Im- provements in survival and clinical benefit with gemcit- abine as first-line therapy for patients with advanced pancreas cancer: a randomized trial显示文摘 | BURRIS H A MOORE M J ANDERSEN J | 1997 | J Clin Oncol1997，15，： | 1 |
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