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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | Effect of levothyroxine replacement on lipid profile and intimamedia thickness in subclinical hypothyroidism:a double-blind,placebo-controlled study显示文摘 | MONZANI F CARACCIO N KOZAKOWA M | 2004 | JClin Endocrinol Metab2004，89，： | 1 |
| 3 | Melanoma contains CD133and ABCG2positive cells with enhanced tumourigenic potential显示文摘 | Monzani E Facchetti F Galmozzi E | 2007 | Eur J Cancer2007，43，93： | 1 |
| 4 | Cognitive function and quality of life in mild thyroid hormone deficiency显示文摘 | Tognini S Pasqualetti G Calsolaro V Polini A Monzani F | 2014 | Recent Pat Endocr Metab Immune Drug Discov2014，8，2： | 1 |
| 5 | Using an intermediate skeleton and inverse kinematics for motion retargeting显示文摘 | Monzani J S Baerlocher P Boulic R | 2000 | Computer Graphics Forum2000，19，3： | 1 |
| 6 | Reversible dioxygen binding and phenol oxygenation in a tyrosinase model system显示文摘 | Gullotti M Monzani E | 2000 | Chem Eur J2000，6，3： | 1 |
| 7 | BRIEF REPORT: Recombinant Human Thyrotropin Reduces Endothelium-Dependent Vasodilation in Patients Monitored for Differentiated Thyroid Carcinoma显示文摘 | Angela Dardano Lorenzo Ghiadoni Yvonne Plantinga Nadia Caraccio Alessia Bemi Emiliano Duranti Stefano Taddei Ele Ferrannini Antonio Salvetti Fabio Monzani | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，： | 1 |
| 8 | 显示文摘 | Monzani F Caracco N Siciliano G | 1997 | J Clin Endocrinol Metab1997，82，10： | 1 |
| 9 | Subclinical hypothyroidism:neurobehavioral features and beneficial effect of L-thyroxine treatment显示文摘 | Monzani F Del GP Caraccio N | 1993 | Clin Investig1993，71，： | 1 |
| 10 | Pharmacokinetics,safety and inducible cytokine responses during a phase I trial of the oral histone deacetylase inhibitor ITF2357(givinostat)显示文摘 | Furlan A Monzani V Reznikov LL | 2011 | Mol Med2011，17，56： | 1 |
| 11 | Thyroid autoimmunity and dysfunction associated with type I interferon therapy显示文摘 | Monzani F Caraccio N Dardano A et la | 2004 | Clin Exp Med2004，3，4： | 1 |
| 12 | Melanoma containsCD133 and ABCG2-positive cells with enhanced tumourigenic potential显示文摘 | Monzani E Facchetti F Galmozzi E | 2007 | EurJ Cancer2007，43，5： | 1 |
| 13 | Cardiovascular risk factors in severe chronic renal failure: the role of dietary treatment 显示文摘 | BERGESIO F MONZANI G GUNSPARINI A | 2005 | Clin Nephrol2005，64，2： | 1 |
| 14 | Effect of levothyroxinereplacement on lipid profile and intima-media thickness in sub-clinical hypothyroidism: A double - blind, placebo - controlledstudy显示文摘 | Monzani F Caraccio N Kozakowa M | 2004 | The Journal of Clinical Endocrinology and Metabolism2004，89，5： | 1 |
| 15 | Determination of bezafi- brate in human plasma and urine by high performance liquid chromatography 显示文摘 | Castoldi D Monzani V Tonfanetti O | 1985 | J Chromatogo Biomed Appl1985，344，8： | 1 |
| 16 | Thyroid autoimmunity and dysfunction associated with type I interferon Therapy显示文摘 | Monzani F | 2004 | Clin Exp Med2004，3，4： | 1 |
| 17 | Determination of bezafibrate in human plasma and urine by high-performance liquid chromatography显示文摘 | Castoldi D Monzani V | 1996 | J Chromatogr1996，687，： | 1 |
| 18 | Lipoprotein profile in subclinical hypothyroidism:response to levothyroxine replacement,a randomized placebo-controlled study显示文摘 | Nadia Caraccio N Ferrannini E Monzani F | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 19 | Melanoma contains CD133and ABCG2positive cells with enhanced tumourigenic poten-tial显示文摘 | Monzani E Facchetti F Galmozzi E | 2007 | Eur J Cancer2007，43，5： | 1 |
| 20 | Effect of levothyroxine replacement on lipid profile and intima-media thicknessin subclinical hypothyroidism:a double-blind,placebo-controlled study显示文摘 | Monzani F Caraccio N Koza`kowa` M | 2004 | J Clin Endocrinol Metab2004，89，： | 1 |
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