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| 1 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 2 | Prevalence and awareness of melasrnn dur-ing pregnancy显示文摘 | Moin A Jabery Z Fallah N | 2006 | Int J Dermatol2006，45，3： | 1 |
| 3 | The effects of air pollution on structures,proteins and allergenicity of pollen grains显示文摘 | Chehregani A Moin M | 2004 | Aerobiologia2004，20，： | 1 |
| 4 | On the relation of near-wall streamwise vortices to wall skin friction in turbulent boundary layers 显示文摘 | Kravchenko A G Choi H Moin P | 1993 | Phys Fluids1993，5，12： | 1 |
| 5 | Grid resolution effects on a model for integrating urban and rural areas 显示文摘 | VALEO C MOIN S M A | 2000 | Hydrological Processes2000，14，14： | 1 |
| 6 | Dendritic cells overexpressing CD95 (Fas) ligand elicit vigorous allospecific T-cell responses in vivo 显示文摘 | Buonocore S Paulart F Le Moine A | 2003 | Blood2003，101，4： | 1 |
| 7 | Mortalityassociatedwithla-teonsetpneumoniaintheintensivecareunit: Resultsofamulticenterco-hortstudy 显示文摘 | Moine P Timsit JF DeLassence A | 2002 | Intensive Care Med2002，28，： | 1 |
| 8 | lnterleukin-9 promotes e- osinophilic rejection of mouse heart a11ografts 显示文摘 | Poulin LF Richard M Le Moine A | 2003 | Transplantation2003，76，3： | 1 |
| 9 | A conditionally immortalized human podocyte cell line demonstrating nephrin and podocinexpression显示文摘 | Moin A S Michael J O’Hare Jochen R | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 10 | Prevalence and awareness of melasmaduring pregnancy显示文摘 | Moin A Jabery Z Fallah N | 2006 | Int J Dermatol2006，45，3： | 1 |
| 11 | On the effect of numerical errors in large eddy simulations of turbulent flows 显示文摘 | Kravchenko A Moin P | 1997 | Journal of Computational Physic1997，131，2： | 1 |
| 12 | Skin picking and sleepdisturbances:Relationship to anxiety and need for research 显示文摘 | Singareddy R Moin A Spurlock L | 2003 | Depress Anxiety2003，18，4： | 1 |
| 13 | Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells显示文摘 | Zuany-Amorim C Sawicka E Manlius C Le Moine A Brunet LR Kemeny DM | 2002 | Nat Med2002，8，： | 1 |
| 14 | Cold liver ischemia-reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin -10 in mice显示文摘 | Moine OH Louis H Demols A | 2000 | Hepatology2000，31，6： | 1 |
| 15 | Optic disc localization in retinal images using histogram matching显示文摘 | DEHGHANI A MOGHADDM H A MOIN M S | 2012 | EURASIP Journal on Image and Video Processing2012，，1： | 1 |
| 16 | Singificance of carbonic fluids in the granulites and skarns of southeast Madagascar 显示文摘 | Ramambazafy A Moine B Rakotondrazafy M | 1998 | Earth Planet Sci Lett1998，327，： | 1 |
| 17 | Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection显示文摘 | Le Moine A Flamand V Demoor F X | 1999 | J Clin Invest1999，103，12： | 1 |
| 18 | The role of fluor-rich fluids in the formation of the thorianite and sapphire deposits from SE Madagascar显示文摘 | Moine B Ramambazafy A Rakotondrazafy M | 1998 | Mineralogical magazine1998，62，： | 1 |
| 19 | Numerical studies of flow over a circular cylinder at ReD=3900显示文摘 | KRAVCHENKO A G MOIN P | 2000 | Physics of Fluids2000，12，2： | 1 |
| 20 | Cold liver ischemia reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in mice显示文摘 | Le Moine O Louis H Demols A | 2000 | Hepatology2000，31，6： | 1 |
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