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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | Endoscopic retrograde cholangiopancreatography outcome from a single referral center in Iran显示文摘BACKGROUND: Endoscopic retrograde cholangiopancreato- graphy (ERCP) is the first choice for diagnostic evaluation of the pancreatic and biliary tree and can be accompanied by a high diagnostic sensitivity and a poor therapeutic outcome. In the current study, we described our experiences in the indications, findings, and technical success of ERCP in a sample of the Iranian population admitted to a referral center in Iran. METHODS: In a retrospective review database-based study, 780 patients (393 males and 387 females; mean age 57.5 years) who had undergone diagnostic and therapeutic ERCP with the primary diagnosis of hepatobiliary disorder between 2006 and 2008 at Taleghani Hospital in Tehran were reviewed. The key data were demographic characteristics, clinical information, laboratory parameters, as well as post-ERCP complications. RESULTS: A history of cholecystectomy was found in about one-third (36.3%) of participants and 80 (10.3%) out of 780 patients had a previous history of biliary stone. A minority (1.4%) of the patients suffered from hepatobiliary carcinomas, and 11 patients had cirrhosis. The most common clinical manifestations in the patients undergoing diagnostic ERCP were icterus (47.3%), weight loss (31.2%), and dark urine (26.9%). Selective biliary cannulation was technically successful in 87.0% of the patients; however, cannulation failed in 13.0%. The most frequent final diagnosis of ERCP was common bile duct stone that was detected in 40.1% of the patients. The ERCP results in 11.0% of the patients were normal. Regarding appropriate treatment, successful stenting was performed in 43 patients (15.2%). Among post-ERCP complications, pancreatitis was the most adverse event withan incidence rate of 3.3%. Other complications including local bleeding, cholangitis and gastrointestinal perforation, rarely occurred. Post-ERCP pancreatitis was reported in 1.8% of men and 3.6% of women (P=0.120). Pancreatitis was more common in women below 70 years than in those who were older than 70 years (3.6% versus 0.5%; OR: 8.216, P=0.015). This might be due to the more functionally active pancreas in younger women than in the older ones. However, other complications were similar in the two age groups. CONCLUSIONS: Based on our experience, ERCP indications, final diagnosis and related complications are comparatively consistent with those reported in other countries. The most common post-ERCP complication is pancreatitis that is more often observed in younger patients. | Amir H Mohammad Alizadeh Esmaeil S Afzali Mirhadi Mousavi Yaghoub Moaddab Mohammad R Zali | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，4： | 3 |
| 3 | Imaging pancreatobiliary ductal system with optical coherence tomography: A review显示文摘An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography(OCT) is a noninvasive, high-resolution(1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of thepancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions. | Mohammad S Mahmud Gray R May Mohammad M Kamal Ahmed S Khwaja Carry Sun Alex Vitkin Victor XD Yang | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 2 |
| 4 | Emergy- based fuzzy optimization approach for water reuse in an eco-industrial park 显示文摘 | MOHAMMAD SADEGH TASKHIRI TAN R R CHIU A S F | 2011 | Resources Conservation and Recycling2011，55，： | 1 |
| 5 | Formation of a dense and continuous AI2O3 layer in nano thermal barrier coating systems for the suppression of spinel growth on the AI2O3 oxide scale during oxidation 显示文摘 | DAROONPARVAR M YAJ1D MUHAMAD A M YUSOF N M HUSSAIN MOHAMMAD S RAD HAMID R B | 2013 | Journal of Alloys and Compounds2013，571，： | 1 |
| 6 | Prediction of failure load of R/C beams strengthened with FRP plate due to stress concentration at the plate end显示文摘 | Amir M M Hamid S Mohammad R E | 1998 | ACI Structural Journal1998，95，1： | 1 |
| 7 | Brucella meningitis 显示文摘 | Hamed R A R Reza A Mohammad S | 2013 | Med J Islam Repub Iran2013，27，2： | 1 |
| 8 | An intriguing effect of lithium perchlorate dispersed on silica gel in the bromination of aromatic compounds by N-bromosuccinimide 显示文摘 | Mojtaba B Najmedin A Mohammad R S | 2005 | Canadian Journal of Chemistry2005，83，： | 1 |
| 9 | Small molecule inhibitors of Bcl-2 family proteins for pancreatic cancer therapy显示文摘 | MASOOD A AZMI A S MOHAMMAD R M | 2011 | Cancers(Basel)2011，3，2： | 1 |
| 10 | Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children 显示文摘 | Mehrotra D Pradhan R Mohammad S | 2008 | Brit J Oral Macitlofac Surg2008，46，： | 1 |
| 11 | Magnetic nanomaterials for hyperther- mia-based therapy and controlled drug delivery显示文摘 | Kumar C S S R Mohammad F | 2011 | Advanced drug de- livery reviews2011，63，9： | 1 |
| 12 | Magnetic nanoma- terials for hyperthermia-based therapy and con- trolled drug delivery 显示文摘 | Kumar C S S R Mohammad F | 2011 | Adv Drug Deliv Rew2011，63，9： | 1 |
| 13 | Removal and recovery of heavy metals from aqueous solution using Ulmus carpinifolia and Fraxinus excelsior tree leaves显示文摘 | MOHAMMAD R S ALI S JAVAD Z | 2008 | Journal of Hazardous Materials2008，155，3： | 1 |
| 14 | Design of broadband,single layer dual-band large re-flectarray using multi open loop elements显示文摘 | MOHAMMAD R JAFAR S NICOLAS G | 2010 | IEEETransaction on Antennas and Propagation2010，58，9： | 1 |
| 15 | Instrumental texture profile analysis (TPA) of date flesh as a function of moisture content 显示文摘 | Mohammad S R | 2005 | Journal of Food Engineering2005，，66： | 1 |
| 16 | Code tracking algorithms for mitigating multipath effects in fading channels for satellite-based positioning显示文摘 | Mohammad Z H B Elena S L and Markku R | 2008 | EURASIP Journal on Advances in Signal Processing2008，，86： | 1 |
| 17 | Preclinical studies of TW-37,a new nonpeptidic small-molecule inhibitor of Bcl-2,in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1显示文摘 | Mohammad R M Goustin A S Aboukameel A | | 0，，07： | 1 |
| 18 | Preparation of cinnamate esters from styrenes显示文摘 | Mohammad A Wayne F S Robert J R | 1997 | J Org Chem1997，62，5： | 1 |
| 19 | Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandihular ankylosis in children 显示文摘 | Mehrotra D Pradhan R Mohammad S | 2008 | Brit J OralMaxillofacSurg2008，46，7： | 1 |
| 20 | Effects of nitrophenols on acetate utilizing methanogenic systems显示文摘 | Mohammad R Poden H Bhattacharya S K | 1995 | Water Research1995，29，2： | 1 |
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