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| 1 | Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: Ex vivo and in vivo studies显示文摘 | Akbar Bayat Farid A. Dorkoosh Ahmad Reza Dehpour Leila Moezi Bagher Larijani Hans E. Junginger Morteza Rafiee-Tehrani | 2008 | International Journal of Pharmaceutics2008，，1： | 2 |
| 2 | Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function显示文摘Background and aim:The liver is the primary organ affected by cholestasis,and complications such as renal injury,renal failure,and the need for renal transplantation are associated with cholestatic liver disease.There is substantial evidence indicating that reactive oxygen species(ROS)and mitochondrial impairment are fundamental mechanisms underlying cholestasis-induced hepatic and renal injury.Edaravone(EDV)is a potent radical scavenger and antioxidant that may prevent oxidative stress and improve impaired mitochondrial function in various diseases.This study was performed to evaluate the effects and mechanisms of action of EDV on hepatic and renal injury in an animal model of cholestasis.Methods:Rats subjected to bile duct ligation(BDL)were treated with EDV 1 or 10 mg/kg/day intraper-itoneally for 14 consecutive days.Biomarkers of oxidative stress and mitochondrial impairment in the liver and kidney were assessed in EDV-treated and untreated rats with cholestasis.Results:Significant increases in tissue ROS level,lipid peroxidation,protein carbonylation,and oxidized glutathione level were detected in rats subjected to BDL.Additionally,significant decreases in tissue glutathione level and antioxidant capacity were observed in the hepatic and renal tissues of rats with cholestasis.Markers of mitochondrial impairment,including mitochondrial depolarization,lipid perox-idation,mitochondrial permeabilization,depleted adenosine triphosphate content,and decreased de-hydrogenase activity,were also detected in rats subjected to BDL.Furthermore,portal inflammation,necrosis,and tissue fibrosis were detected in the liver and significant tubular atrophy and interstitial inflammation,as well as fibrotic lesions,were detected in the kidneys of rats with cholestasis.EDV treatment significantly mitigated cholestasis-associated hepatic and renal injury.Conclusions:The antioxidative properties of EDV and its positive effects on the indices of mitochondrial function may be critical factors contributing to protection against cholestasis-associated hepatic and renal injury. | Mohammad Mehdi Ommati Hanie Attari Asma Siavashpour Marzieh Shafaghat Negar Azarpira Hasti Ghaffari Leila Moezi Reza Heidari | 2021 | Liver Research2021，5，3： | 2 |
| 3 | Evidences for involvement of nitric oxide in the gastroprotective effect of bromocriptine and cyclosporin A on water immersion stress-induced gastric lesions显示文摘 | Samini M Moezi L Jabarizadeh N | 2002 | Pharmacol Res2002，46，6： | 1 |
| 4 | Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats显示文摘 | Gaskari S A Liu H Moezi L | 2005 | Br J Pharmacol2005，146，3： | 1 |
| 5 | Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors显示文摘 | Moezi L Gaskari SA Liu H | 2006 | Br J Pharmacol2006，149，7： | 1 |
| 6 | A comparative study of whole body vibration training and conwentional training on knee proprioception and postural stability after anterior cruciate ligament reconstruction显示文摘 | Moezy A Olyaei G Hadian M | 2008 | Br J Sports Med2008，42，5： | 1 |
| 7 | A comparative study of whole body vibration training and conventional training on knee proprioception and postural stability after anterior cruci- ate ligament reconstruction 显示文摘 | Moezy A Olyaei G Hadian M | 2008 | Br J Sports Med2008，42，5： | 1 |
| 8 | Evidences for involvement of nitric oxide in the gastro protective affect of bromocriptine and cy-closporine A on water immersion stress-induced gastric lesions显示文摘 | Samini M Moezi L Jabarizadeh N | 2002 | Pharmacia Res2002，46，6： | 1 |
| 9 | A comparative study of whole body vibration training and conventional training on knee proprioception and postural stability after anterior cruciate ligament reconstruction显示文摘 | MOEZY A OLYAEI G HADIAN M | 2008 | Br J Sports Med2008，42，5： | 1 |
| 10 | Enhancedanti-ulcer effect of pioglitazone on gastric ulcers in cirrhoticrats :the role of nitric oxide and IL-1β显示文摘 | Moezi L Heidari R Amirghofran Z | 2013 | PharmacolRep2013，65，1： | 1 |
| 11 | A comparative study ofwhole body vibration training and conventional training on kneeproprioception and postural stability after anterior cruciate ligamentreconstruction 显示文摘 | Moezy A Olyaei G Hadian M | 2008 | Br J Sports Med2008，42，5： | 1 |
| 12 | Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB ( 1 ) and VR(1) receptors 显示文摘 | Moezi L Gaskari SA Liu H | 2006 | Br J Pharmacol2006，149，7： | 1 |
| 13 | Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors显示文摘 | Moezi L Gaskari SA Liu H | 2006 | Br J Pharmacol2006，149，7： | 1 |
| 14 | Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats:the role of nitric oxide and IL-1 beta显示文摘 | Moezi L Heidari R Amirghofran Z | 2013 | Pharmacol Rep2013，65，1： | 1 |
| 15 | A phase I trial ofpan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infu-sion in combination with carboplatin and etoposide in patients withextensive-stage small cell lung cancer显示文摘 | ChiapporiAA Schreeder MT Moezi MM et ai | 2012 | Br J Cancer2012，106，： | 1 |
| 16 | Land suitability evaluation using ordered weight averaging with fuzzy quantifier in Shavoor Plain, Iran显示文摘 | Mokarram M Askari M S Moezi A A | 2011 | Research on Crops2011，12，2： | 1 |
| 17 | A comparative study of whole body vibration training and conventional training on knee proprioception and postural stability after anterior cruciate ligament reconstruction显示文摘 | Moezy A Olyaei G Hadian M | 2008 | Br J Sports Med2008，42，5： | 1 |
| 18 | Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice:role of nitric oxide and μ receptors显示文摘 | Shafaroodi H Baradaran N Moezi L | 2011 | Epilepsy Behav2011，20，4： | 1 |
| 19 | Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis显示文摘 | Ebrahimkhani MR Moezi L Kiani S | 2008 | Dig Dis Sci2008，53，11： | 1 |
| 20 | Gastric heading ef- fect of melatonin against different gastroinvasive agents in cholestatic rats显示文摘 | Moezi L Nasiripoor S Mohajer V | 2010 | Pathophysiology2010，17，1： | 1 |
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